NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	6834-92-0
Chemical Name	disodium metasilicate
Substance ID	m-nite-6834-92-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Nonflammable (SIDS (accessed in December 2008), ICSC (J) (2004)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	It is nonflammable and not pyrophoric (SIDS (accessed in December 2008), ICSC (J) (2004)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Nonflammable.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Its water solubility is 200 g/L (20degC) (IUCLID (2000)) and it is stable in contact with water.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on its rat LD50 values: 1750 (male), 1152-1349 (both sexes), 800, and 600 mg/kg bw (SIDS (accessed in December 2008)) and 1280 mg/kg (PATTY (5th, 2001)), the substance was classified into Category 4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In several 4-hour skin irritation tests using rabbits (OECD guidelines 404; SIDS (accessed in December 2008)), necrosis was observed in the skin and the substance was concluded to be corrosive. In addition, it is rated as C (corrosive)—R34 in the EU classification. Based on this information, the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Since the substance is documented to be corrosive in rabbit eye tests (IUCLID (2000)) and it is a skin corrosive substance (Category 1), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Negative results were obtained in the Local Lymph Node Assay using mice (OECD guidelines 429). In addition, there is a case report on hives developed by contact in a human, and a report that the same person developed an ulcer and a wheal by a patch test (30 people in control groups showed a negative reaction) (SIDS (accessed in December 2008)). However, classification is not possible due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results obtained in chromosomal aberration tests using mouse bone marrow cells (in vivo mutagenicity tests using somatic cells) (SIDS (accessed in December 2008)), the substance was classified into "Not classified". In vitro mutagenicity tests (Ames tests) also yielded negative results (SIDS (accessed in December 2008)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	In both 14-month and 2-year oral administration tests using rats (SIDS (accessed in December 2008), IUCLID (2000)), no signs of carcinogenicity were detected. Classification is not possible based on this dataset alone, however, as data on other animal species are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Oral exposure of mice during the gestational period showed no effects on development of their offspring (SIDS (accessed in December 2008)). However, due to lack of data on sexual functions and fertility of parental animals, classification is not possible.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In oral administration tests using rats (doses: 538-2000 mg/kg bw for males, and 910-2600 mg/kg bw for females), lethargy, increased breathing frequency, platycoria, and cramps were observed (SIDS (accessed in December 2008)). In other oral administration tests using rats (dose: 1750 mg/kg bw), apathy, staggering gait, and dyspnoea were observed (SIDS (accessed in December 2008)). In addition, in oral administration tests using mice (doses: 500-1920.8 mg/kg for males, and 500-1372 mg/kg for females) (SIDS (accessed in December 2008) lethargy was observed. Since nervous symptoms such as lethargy, cyanosis, platycoria, dyspnoea, and paralysis of hind legs were observed at the doses that fall under Category 2 guidance values, the substance was classified into Category 2 (nervous system).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	In 3-month tests using rats that underwent oral administration in drinking water (tests similar to those of OECD TG408) (doses: 200, 600 or 1800 ppm (26.4, 76.2 or 227.1 mg/kg/day for males, and 32.1, 97.6 or 237.2 mg/kg/day for females)), NOAEL was > 227-237 mg/kg bw, which was higher than Category 2 guidance values; no effects of administration were observed. Similarly, in other 3-month tests using rats that underwent oral administration in drinking water (doses: 750, 1500 or 3000 ppm (23, 47 or 110 mg/day for males, and 21, 37 or 84 mg/day for females)), no effects of administration were observed. In addition, in 3-month tests using mice that underwent oral administration through drinking water (doses: 300, 900 or 2700 ppm for males, and 333, 1000 or 3000 ppm for females), NOAEL was 260-284 mg/kg bw, which was higher than Category 2 guidance values; no notable effects were observed at the highest dose tested other than an increase in liver weight and a decreased leukocytes in females. Since none of the tests found any effects at the doses within Category 2 guidance values, the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Since its 96h LC50 = 210 mg/L for fish (zebra fish) (IUCLID 2000), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Since it is not sparingly soluble in water (water solubility: > 200 g/L, IUCLID 2000) and its classification for acute toxicity is "Not classified," the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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