Item | Information |
---|---|
CAS RN | 68603-42-9 |
Chemical Name | Coconut oil diethanolamine condensate |
Substance ID | m-nite-68603-42-9_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not an aerosol product. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified |
- |
- | - | A flash point is 103 degrees C (closed cup) (GESTIS (Access on July 2015)). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No established test method suitable for liquid substances. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Not containing metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | It is an organic compound which does not contain fluorine or chlorine but contains oxygen, and the oxygen is not chemically bonded to the elements other than carbon or hydrogen. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | "Liquids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an organic compound that does not contain bivalent -O-O- structure in the molecule. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Due to no data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | From reported LD50 values of 12,200 mg/kg and > 5,000 mg/kg for rats (HSDB (Access on July 2015)), it was classified as "Not classified." | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, an LD50 value of > 2,000 mg/kg for rabbits was reported for commonly distributed products of this substance (HSDB (Access on July 2015)). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | "Solids" according to GHS definition. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
It is reported that moderate irritation was observed after 23-hour application of a 30% solution to this substance in rabbits (NTP TR 479 (2001)). Besides, as for humans, there are multiple reports of irritation by hand gel, shampoo, hydraulic oil and so on containing this substance, and it is reported that this substance was a causal substance in a patch test (NTP-TR 479 (2001), HSDB (Access on July 2015)). The substance was classified in Category 2 from the above results. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | The classification is not possible due to lack of data. Besides, it is reported that this substance was not sensitizing in a patch test of shampoo containing 2% this substance in 104 women, (HSDB (Access on July 2015)), and that one out of 40 workers handling this substance showed a sensitization reaction in a patch test (HSDB (Access on July 2015)). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
As for in vivo, a micronucleus test in peripheral erythrocytes of male and female mice after a 14-week dermal application was positive in both males and females (NTP TR 479 (2001), IARC 101 (2012)). As for in vitro, a bacterial reverse mutation test, a mouse lymphoma test, a chromosomal aberration test, and a sister chromatid exchange test in cultured mammalian cells were all negative (NTP TR 479 (2001), IARC 101 (2012)). From the above, although an in vivo mutagenicity test in somatic cells showed positive, there were all negative results in vitro. The substance was classified in Category 2 according to the GHS classification guidance for the Japanese government. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Category 2 |
Warning |
H351 | P308+P313 P201 P202 P280 P405 P501 |
There is no usable human information on the carcinogenicity of this substance. As for experimental animals, in a 2-year carcinogenicity test using rats or mice in a dermal route, increased incidences of the following were observed (NTP TR 479 (2001)): renal tubule adenoma or carcinoma (combined) (females only) in rats; and liver tumors (hepatocellular adenoma, hepatocellular carcinoma, hepatoblastoma) (males and females), renal tubule adenoma (alone), renal tubule adenoma or carcinoma (combined) (males) in mice. It is written in the NTP report that kidney tumors in female rats as "equivocal evidence," and it is stated in the assessment by IARC that "there is no increased incidence of tumors in a rat test." However, it is written in both NTP and IARC that increased incidences of hepatic and renal tumors in mice are clear evidence of carcinogenicity (NTP TR 479 (2001), IARC 101 (2012)). By taking the above results into account, IARC classified the substance in Group 2B (IARC 101 (2012)), and it was classified in Category 2 also in this classification. |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (thyroid, liver, kidney) |
Warning |
H373 | P260 P314 P501 |
There is no human information. As for experimental animals, in a 14-week dermal administration toxicity test using rats, at 100 mg/kg/day (converted to a 90-day equivalent: 78 mg/kg/day) within a range of Category 2 or higher, renal tubule regeneration in females were observed except for skin lesions at application sites (epidermal hypertrophy, sebaceous gland hyperplasia, chronic active inflammation, parakeratosis, and ulcer) (NTP TR 479 (2001)). In a 2-year dermal administration toxicity/carcinogenicity test using rats, at 50 mg/kg/day within a range of Category 2 or higher, increased incidences of chronic active inflammation, epithelial hyperplasia, ulcer of forestomach, and nephropathy were observed except for skin lesions at application sites (epidermal hypertrophy, sebaceous gland hyperplasia, parakeratosis, hyperkeratosis) (NTP TR 479 (2001)). In a 2-year dermal administration toxicity/carcinogenicity test using mice, at 100 mg/kg/day within a range of Category 2 or higher, foci with eosinophilic variation in hepatocytes in the liver, thyroid follicular cell hyperplasia were found except for skin lesions at application sites (epidermal hypertrophy, sebaceous gland hyperplasia, hyperkeratosis) (NTP TR 479 (2001)). As above, except for skin lesions at application sites, nephropathy, chronic active inflammation of forestomach, eosinophilic foci in the liver, and thyroid follicular cell hyperplasia were observed in a range of Category 2. Besides, forestomach was excluded from target organs because human does not have one. Therefore, the substance was classified in Category 2 (thyroid, liver, kidney). |
FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Due to lack of data, the classification is not possible. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | The classification is not possible because appropriate data are not obtained. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data. | FY2015 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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