NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	691-37-2
Chemical Name	4-Methyl-1-pentene
Substance ID	m-nite-691-37-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point of -7 degrees C [closed cup] (Bretherick (7th, 2007)), which is < 23 degrees C, and an initial boiling point of 53.9 (Lide (90th, 2009)) degrees C, which is > 35 degrees C, correspond to Category 2. Besides, it is classified in class 3PGII in UNRTDG (UN2288).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Type G	- -	-	-	There is a chemical group present in the molecule associated with a self-reactive property (unsaturated bond), but it was concluded from Class 3 in UNRTDG (UN2288) which does not correspond to a higher self-reactive property (class 4.1, PGI) that it is classified in Type G.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an ignition temperature of 300 degrees C (Ullmanns (E) (6th, 2003)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain oxygen, fluorine, or chlorine.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Not classified	- -	-	-	Steel, stainless steel, and aluminum are durable as a container (Hommel (1985)),	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From an LD50 value of >2000 mg/kg and no death at a dose of 2000 mg/kg in rats (OECD TG423, GLP compliance) (Report on Toxicity Tests of Chemical Substances, MHLW (2007)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, negative results were reported in both an Ames test and a chromosomal aberration test using Chinese hamster lung derived cells (Report on Toxicity Tests of Chemical Substances, MHLW (Access on May 2011)) as in vitro tests.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In an oral administration combined repeated dose toxicity test with reproduction/developmental toxicity screening test in rats (OECD TG422, GLP compliance), dose-related changes in sex function and fertility such as sex cycle in females, indices of mating, fertility, birth, implantation, and delivery in all groups were not found. Adverse effects on the development of the offspring such as a number and sex ratio of offspring born, a number of live offspring and live birth index on lactation day 0, a number of live offspring, and viability index on lactation day 4 were not observed. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on May 2011)) But, there are no fetal data at the end of a gestation period, it was classified as "Classification not possible" due to lack of data on effects on the development of the offspring including teratogenicity.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	In an oral administration test given 300 or 2000 mg/kg to rats (OECD TG423, GLP compliance), neither mortality nor abnormalities in clinical signs and necropsy were found. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on May 2011)) But blood biochemical test and histological test were not conducted. Therefore, it was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In an oral administration combined repeated dose toxicity test with reproduction/developmental toxicity screening test in rats given 40, 200, 1000 mg/kg/day (OECD TG422, GLP), adverse effects were not found except for increased urea nitrogen at a dose of 1000 mg/kg in females, and slight dose-dependent increases in the hyaline droplet and eosinophilic body in the proximal tubular epithelium in the kidney at doses of 200mg/kg or higher in males. (Report on Toxicity Tests of Chemical Substances, MHLW (Access on May 2011)) Accordingly, no adverse effects at a high dose of 1000 mg/kg/day (converted to 90-day equivalent volume: 446.7 mg/kg/day) as a result correspond to "Not classified" in an oral route. However, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures) because effects in other routes (inhalation, dermal) are unknown due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Because acute toxicity data for algae, crustacea, and fish in concentrations around the water solubility were not reported (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan (2003)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" because chronic toxicity data in concentrations up to the water solubility were not reported (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan (2003)) despite lack of rapid degradability (hardly degradable, a degradation rate by BOD: 1 % (the existing chemicals survey program, 2005)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not available, then it is classified as "Not classified" from 96-hour LC50 => 0.076 mg/L for fish (Oryzias latipes) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan (2003)), and it is classified as "Not classified" from poor water solubility (measured water solubility: 48 mg/L (PHYSPROP Database, 2012)) and low bioaccumulation (low bioaccumulative: log Kow＞3.38 (the existing chemicals survey program, 2005)) but lack of rapid degradability (hardly degradable, a degradation rate by BOD: 1 % (the existing chemicals survey program, 2005)). From the above results, it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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