Item | Information |
---|---|
CAS RN | 709-98-8 |
Chemical Name | 3',4'-Dichloropropionanilide |
Substance ID | m-nite-709-98-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified |
- |
- | - | Non-flammable (ICSC (2004)) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive or self-reactive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Non-flammable (ICSC (2004)) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Non-flammable (ICSC (2004)) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Classified as "solid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements) |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no "-O-O-" structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 91.0degC (Agricultural Chemical Registration Data)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on the rat LD50 (oral route) value of 840mg/kg (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >1.24mg/L (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | In the available rabbit skin irritation tests, the affected animals exhibited a Draize score of 0.2 at 1 hour after application, but all signs cleared up by 24 hours (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Based on the evidence of moderate irritation observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Not classified |
- |
- | - | No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1989)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | Based on negative data in in vitro reverse mutation tests and in vivo chromosome aberration tests on rat bone marrow cells (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Not classified |
- |
- | - | There was no evidence of treatment-related incidence of tumor formation observed in mouse carcinogenicity studies (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Not classified |
- |
- | - | Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1989)). |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic) |
Warning |
H371 | P308+P311 P260 P264 P270 P405 P501 |
Based on the evidence from animal studies including "reduced locomotor activity," "abnormal gait," "prone position," "hypopnea," "lacrimation," "reddish tear," "exophthalmos" and "cyanosis" (Agricultural Chemical Registration Data (1989)). No target organs were identified from these findings. These effects were observed at dosing levels within the guidance value ranges for Category 2. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | Insufficient data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 14-day EC50 (growth) = 0.11 mg/L for higher aquatic plants (Lemna gibba) (EPA AQUIRE: 2018, EPA Pesticide Ecotoxicity Database (1992)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
It was classified in Category 1 due to being not rapidly degradable (not readily degradable, an average degradation rate by BOD: 21% (J-CHECK, 1976)), and 54-day NOEC (length) = 0.0004 mg/L for fish (Pimephales promelas) (EPA AQUIRE: 2018, Call, D. J. et al. (1983)). | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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