NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	71-23-8
Chemical Name	n-Propyl alcohol
Substance ID	m-nite-71-23-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 2 since flash point 15 degC (ICSC (J) (1999)) is <23 degC and boiling point is 97 degC, further the substance is classified into Class 3, PG II in UNRTDG (UN1274).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 371 degC (ICSC (J) (1999)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	LD50 values are 1900 mg/kg (ACGIH (2004)), 1870 mg/kg (PATTY (4th, 1994)), 5400 mg/kg (PATTY (4th, 1994)), 6500 mg/kg (PATTY (4th, 1994), EHC 102 (1990)) and 2200 mg/kg (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (vol. 6, 2008)) for rats, and two values correspond to Category 4 and three values correspond to "Not classified" in JIS Classification. The substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification) since 3 of 5 LD50 values are in this category.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on LD50 values of 6700 mg/kg (PATTY (5th, 2001), ACGIH (2007)), 4060 mg/kg (ACGIH (2007)), 4000 mg/kg (PATTY (5th, 2001)) and 4050 mg/kg (EHC 102 (1990)) for rabbits, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. As relevant information, 2/6 rats died during 4-hour exposures at 4000 ppm (9.84 mg/L) (EHC 102 (1990), PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on results of "very slightly irritating" and "no irritating" in rabbit tests (PATTY (5th, 2001), IUCLID (2000)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a report that when the substance was applied to the eyes of rabbits, severe conjunctivitis, iritis, corneal opacities and ulcerations were observed (ACGIH (2004), PATTY (5th, 2001)). The substance is classified into Xi; R41 in EU classification. Based on these information, the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	There is a result of "not sensitizing" in a guinea pig maximization test. However, the information is reported in a document in List 2 and lacks detailed data (IUCLID (2000)). There is also a result of "not sensitizing" in a mouse ear-swelling test. However, the method employed in the conduct of the test is not recommended for classification (EHC 102 (1990)). Classification was not possible due to lack of sufficient data. As relevant information, in humans, there is a case report of positive result in a patch test (EHC 102 (1990)) but there is a result of "not sensitizing" in another patch test (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is a report that structural chromosomal aberration and aneuploidy were observed in a rat bone marrow chromosomal aberration test by oral administration (in vivo somatic cell mutagenicity test) (BUA Report No. 190 (1998)), the result was not used as the basis for classification due to imperfection of the evidence and methodology shortcomings. As relevant information, from in vitro mutagenicity tests, there are reports of a negative Ames test, a negative micronucleus test and a negative sister chromatid exchange test using hamster culture cells (ACGIH (2007), PATTY (5th, 2001), EHC 102 (1990)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classification of "A4" in ACGIH (2007), the substance was classified as "Not classified". In two animal tests, increased incidences of liver sarcomas were observed but the substance was not classified into "A3" based these test results because of lack of adequate details regarding experimental design and the use of a single dose in each test (ACGIH (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In an inhalation test, male rats exposed to the substance for 6 weeks were mated to unexposed females. The female rats then exposed to the substance from days 1 to 19 of gestation. A marked reduction in male fertility (ACGIH (2007)) and a remarkable increase in resorptions (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2008), PATTY (5th, 2001)) were observed at dose levels in which maternal general toxicity was noted, as evidenced by reduced body weight gain and reduced food consumption. Based on the data, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	Deep narcosis was observed in mice following inhalation exposure of the substance (EHC 102 (1990), PATTY (5th, 2001)). The ED50 values for narcosis in rabbits is reported to be 1440 mg/kg bw orally (EHC 102 (1990)). Based on the data, the substance was classified into Category 3 (narcotic effects). Since the threshold value for irritation (eyes and nose) in humans is reported to be 4,000 - 16,000 ppm, the substance was classified into Category 3 (respiratory tract irritation). The principal toxic effect following a single exposure is depression of the central nervous system (EHC 102 (1990)). In the only fatal poisoning case reported, it was recorded that a woman was found unconscious and died 4 - 5-hour after ingestion of approximately a half a liter of the compound as a solvent in a cosmetic preparation (EHC 102 (1990)). No other adverse effects were reported.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. In 13-week and 1.5-year oral tests in rats, fatty degeneration, necrosis and fibrosis in the liver and hyperplasia of hematopoietic parenchyma in the bone marrow were reported (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2008), EHC 102 (1990), BUA Report No. 190 (1998)). Since the effects were observed at dose levels exceeding the guidance value range, the information was not used as the basis of classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	Since the substance is a mixture of n-primary alcohols with a composition of at least 3 carbon atoms but not more than 13, the substance corresponds to Category 2 in GHS classification. However, classification was not possible due to lack of data corresponding to Category 1 and according to guidance of JIS Classification in which category 2 is not set.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified into Not classified from its 48h-LC50 = 3025 mg/L for Crustacea (Daphnid) (EHC 102, 1990, etc).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since its acute toxicity is Not classified and it is not non-water soluble (Water solubility = 1000000 mg/L (PHYSPROP Database, 2009).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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