NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	71-41-0
Chemical Name	1-Pentanol
Substance ID	m-nite-71-41-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Classified into Category 3 since flash point 33 degC (closed-cup) (Ullmanns (E) (2003)). The substance is classified into Class 3, PG III in UNRTDG (UN1105).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified	- -	-	-	Auto-ignition point is 300 degC (Lide (88th, 2008)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values of 2690 mg/kg and 3030 mg/kg for rats (PATTY (5th, 2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on LD50 values of 2000 mg/kg, 4500 mg/kg (PATTY (5th, 2001)), and >3200 mg/kg (PATTY (5th, 2001)) for rabbits, the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data. As relevant information, no mortality was observed in rats exposed to saturated vapours of the substance (estimated concentration: 6.2 mg/L/8h (8.8 mg/L/4h)) at 22 degC (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on a report that 2/10 rats died during the exposure of the aerosol at 14 mg/L/6h (21mg/L/4h) (PATTY (5th, 2001), a LC50 value was >14 mg/L/6h (21mg/L/4h) and the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	Based on a report that severe irritation was observed after a 24-hour closed application to rabbits (PATTY (5th, 2001)) and EU classification as Xi; R37/38 (EU-Annex I (access on May 2009)), the substance was classified into Category 2. As relevant information, there are reports "irritating for rabbits" (IUCLID (2000)) and "not irritating after 4-hour closed application to rabbits" (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 2A	Warning	H319	P305+P351+P338 P337+P313 P264 P280	Based on a report that application to rabbits caused severe irritation such as redness and swelling of the conjunctivae, iritis and corneal injury (PATTY (5th, 2001)), a report of reversible severe irritating in a rabbit Draize test (IUCLID (2000)) and severe corneal injury in rabbits with a degree of irritation of 8 of 10 (IUCLID (2000)), the substance was classified into Category 2A.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there are reports of a negative Ames test (NTP DB (access on Aug. 2009), a negative human lymphocytes chromosome aberration test (IUCLID (2000)), and a positive V-79 cell chromosome aberration (including aneugenic) test (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	Although there is a report that there was no evidence of developmental toxicity in a rat test by repeated inhalation of saturated vapours on days 1 to 19 of gestation (PATTY (5th, 2001)), classification was not possible due to lack of data for sexual function and fertility of parental animals.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	Since neurotoxic effects include delirium, deafness, diplopia, CNS depression, preconvulsive movement were reported as human health effects (HSDB (2006)) and the information are reported in a document in List 2, the substance was classified into Category 2 (central nervous system). In addition, based on a report that the vapour may be irritating to upper respiratory tract (HSDB (2006)) and classification into Xi; R37/38 in EU classification (EU-Annex I (access on May 2009)), the substance was classified into Category 3 (respiratory tract irritation). Additionally, there is a report that appreciable lung edema was observed in the mice inhaling the aerosol at a dose exceeding the upper limit of the guidance value range for Category 2 (PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a rat repeat oral administration test at dose levels of up to 1000 mg/kg for 13 weeks, there were no treatment related effects on food and water consumption, hematologic and serum chemistry values, urinalysis, renal function, organ weights, or histopathology (PATTY (5th, 2001)). The substance corresponds to "Not classified" with oral exposure. However, classification was not possible due to lack of data with other exposure routes.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	Since the kinematic viscosity is estimated to be 14 mm2/s or less at 40 degC, extrapulated from 4.1 mm2/s (20 degC), (Ullmanns (E) (2003)) and the substance is n-primary alcohols with a composition of at least 3 carbon atoms but not more than 13, the substance corresponds to Category 2 in GHS classification. However, classification was not possible according to guidance of JIS Classification in which category 2 is not set. As relevant information, there is information that aspiration of 0.2 mL caused deaths in 10 out of 10 rats (PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	Classified into Category 3 from its 48h-EC50 = 53 mg/L for Crustacea (Ceriodaohnia dubia) (AQUIRE, 2010)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since it is rapidly degradable (BOD: 87, 95, 94%, TOC: 100, 98, 99, GC: 100, 100, 100% (Biodegradation and Bioconcentration of Existing Chemical Substances under the Chemical Substances Control Law, 2008)) and its bioaccumulation potential is estimated to be low (log Kow = 1.51 (PHYSPROP Database, 2010)) though its acute toxicity is Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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