NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	71048-99-2
Chemical Name	4-[(Hydroxy)(methyl)phosphinyl]-L-Abu-L-Ala-L-Ala-ONa
Substance ID	m-nite-71048-99-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified	- -	-	-	Non-pyrophoric when in contact with air at a room temperature and used as agricultural chemicals.	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Stable to water. (The value of aqueous solubility is acquired. Moreover, as pesticide, many are produced commercially as a water-soluble powders.)	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Because the LD50 in rats was 268mg/kg (RTECS (2004), the Journal of Pesticide Science (1987)), the substance was classified as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	-	- Warning	-	-	It was set as Category 5 based on rat LD50 = 3g/kg (RTECS (2002) and Pesticide Science Society of Japan (1987)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Rat LC50 value in inhalation is 2570mg/m3 (= 2.57mg/L, RTECS, 2002; Pesticide Science Society of Japan, 1987). But there was no description of steam or dust/mist, and also no vapor pressure data. It could not judge to be either, so it was presupposed that it cannot be classified due to data insufficiency. In addition, it is Category 3 if it is assumed to be steam, and it is Category 4 if it is assumed to be dust/mist.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Rat LC50 value in inhalation is 2570mg/m3 (= 2.57mg/L, RTECS, 2002; Pesticide Science Society of Japan, 1987). But there was no description of steam or dust/mist, there was also no vapor pressure data, and it could not be judged either one. Therefore, it cannot be classifid since data was insufficient. In addition, it corresponds to category 3 if it assumes that it is steam, and category 4 if it assumes to be dust/mist.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Not classified	- -	-	-	Since block paste of 0.5g of this product did not indicate irritation to the rabbit skin (Pesticide Science Society of Japan, 1987), it carried out the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Although the result of administeration to the rabbit eye of 0.1g of this product showed very slight stimulativeness, but it recovered after 48 hours (Pesticide Science Society of Japan, 1987). Therefore, it was classified into Category 2B.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	Since very slight causing sensitivity was acknowledged in the quality of a genuine article (Pesticide Science Society of Japan, 1987) with the Draize method using a guinea pigs, the ratio of the positive animal was set to Category 1 though it was unknown. In addition, the 20% water-soluble powders of this product did not indicate sensitizing by the maximization method which used the guinea pigs (Pesticide Science Society of Japan, 1987).	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although it is negative in the in vitro mutagenicity test (Ames examination, and in vitro chromosomal aberration test) (Pesticide Science Society of Japan, 1987), there is no in vivo mutagenicity test data. So it cannot taxonomic according to lack of data.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	In chronic toxicity and carcinogenicity test in rat and mouse, significant development of tumor was not observed (Journal of Pesticide Sci. Soc. of Japan, 1987). So it was out of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In the effect test exerted on the next-generation using a rat (generation reproduction and teratogenicity), delayed ossification and decreasing in fetus weight was seen in the dose which indicated maternal toxicity (Pesticide Science Society of Japan (1987)), so it was set as Cayegory 2. On the other hand, in the teratogenicity study using rat and rabbit, it was negative (Pesticide Science Society of Japan (1987)).	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	The substance was classified as Category 1 (central nervous system) because in a report which is equivalent to a Priority 1 document, there are inertia, salivation, clonic convulsions and increased irritability to outside stimuli in a rat acute oral administration test at the dosages within the guidance values (=<300mg/kg) of Category 1(Pesticide Science Society of Japan, 1987) .	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Not classified	- -	-	-	Although in a document equivalent to priority 1, hypertrophy of the renal proximal tubule and the increase of kidney weights were observed in the subacute toxicity study for three months and the chronic toxicity and carcinogenicity test for 24 months of a rat, since degenerative change except renal dysfunction and increase of an smooth endoplasmic reticulum was not observed (Pesticide Science Society of Japan, 1987), it considered as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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