Item | Information |
---|---|
CAS RN | 71561-11-0 |
Chemical Name | 2-[4-(2,4-dichlorobenzoyl)-1,3-dimethyl-5-pyrazolyloxy]acetophenone; Pyrazoxyfen |
Substance ID | m-nite-71561-11-0_v2 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] It was classified in Category 4 from (1). [Evidence Data] (1) LD50 for rats: females: 1,644 mg/kg, males: 1,690 mg/kg (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. There was information of (1), but because exposure time was unknown, the classification was not possible. Besides, because an exposure concentration was higher than the saturated vapor pressure concentration (7.8E-006 mg/L), a reference value in the unit of mg/L was applied as dust. [Reference Data, etc.] (1) LC50 for rats (exposure time: unknown): > 0.28 mg/L (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)) (2) Vapor pressure of this substance: 3.6E-007 mmHg (25 deg C) (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)) (converted value for the saturated vapor pressure concentration: 7.8E-006 mg/L) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) In a skin irritation test with rabbits, no irritation was observed (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] There was a description of (1), but the classification was not possible. Because data in the previous classification could not be confirmed, and details such as scores were unknown, the classification result was changed. [Reference Data, etc.] (1) In an eye irritation test with rabbits, no changes in the cornea or iris were seen, and slight erythema, edema, and discharge in the conjunctiva were observed but disappeared 48 hours after application (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Because the rationale data for the previous classification could not be confirmed, the classification result was changed. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Because Agricultural Chemical Registration Data used in the previous classification could not be obtained, the classification result was changed based on the newly obtained information. [Evidence Data] (1) As for in vitro, a negative result was obtained in a bacterial reverse mutation test (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There were no available reports in humans. From (1), it was classified as "Not classified." [Evidence Data] (1) In carcinogenicity tests by diet administration of this substance to male and female rats for 104 weeks and male and female mice for 104-106 weeks, no treatment-related neoplastic lesions were observed in either species (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1991)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified." [Evidence Data] (1) In a two-generation reproductive study with rats dosed by feeding, hepatocellular swelling was observed as parental toxicity in F2-generation males, but no effect on fertility was observed, and no effect on development of offspring was observed either (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1988)). (2) In a teratogenicity test with female rats dosed by gavage on days 6 to 15 of gestation, a decrease in fetal weight and a decrease in ossification were observed at doses at which maternal toxicity (reduced body weight gain) was observed, but no teratogenicity was observed (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1988)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification was not possible due to lack of data. Since the information source used in the previous classification was currently unavailable, and the information on this substance could not be obtained from a new information source either, the classification result was changed from the previous classification. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver) |
Danger |
H372 | P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 1 (liver). Since the evidence data for the previous classification was currently unavailable and could not be confirmed, the classification result was changed from the previous classification as a result of a review based on available information. [Evidence Data] (1) As a result of a chronic toxicity/carcinogenicity study with rats, bile duct proliferation and bile duct fibrosis in females at 30 ppm (1.5 mg/kg/day, within the range for Category 1), a decrease in leukocyte count and decrease in LDH in males, and a decrease in creatinine in females at or above 300 ppm (15 mg/kg/day, within the range for Category 2), and ocular cloudiness (keratitis due to adhesion of the test substance in powder feed), a decreasing tendency of food and water consumption, reduced body weight gain, a decrease in platelet count, and a decrease in AST in males and females at 1,000 ppm (50 mg/kg/day, within the range for Category 2) were observed (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1988)). [Reference Data, etc.] (2) As a result of a 4-week test with mice dosed by feeding, centrilobular hepatocellular swelling and fatty change in males and females at or above 1,250 ppm (187.5 mg/kg/day (converted guidance value: 58 mg/kg/day, within the range for Category 2)), and an increase or an increasing tendency of liver and spleen weight in males and females, and renal tubular epithelium swelling in males at 3,000 ppm (450 mg/kg/day (converted guidance value: 140 mg/kg/day, exceeding Category 2)) were observed (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1988)). (3) As a result of a 4-week test with rats dosed by feeding, an increase in liver weight in males and females, and reduced body weight gain in females at or above 250 ppm (12.5 mg/kg/day (converted guidance value: 3.9 mg/kg/day, within the range for Category 1)); and a decrease in total globulin and an increase in A/G ratio in males and females, reduced body weight gain and a decrease in total leukocyte count in males, and a decrease in total protein and a decrease in BUN in females at 1,250 ppm (62.5 mg/kg/day (converted guidance value: 19.4 mg/kg/day, within the range for Category 2)) were observed (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1988)). (4) As a result of a chronic toxicity/carcinogenicity study with mice, darker color of the liver and hyperkeratosis of the forestomach mucosa epithelium in males and females, and an increase in relative liver weight and centrilobular hepatocellular swelling in males at 30 ppm (4.5 mg/kg/day, within the range for Category 1); reduced body weight gain and lowered urine pH in males and females, and an increase in urobilinogen positive individuals, increases in absolute and relative liver weight, and centrilobular hepatocellular swelling in females at or above 300 ppm (45 mg/kg/day, within the range for Category 2); and a decrease in food and water consumption in males and females, an increase in urobilinogen positive individuals and increases in ALP and AST in males, and a decrease in total cholesterol and sugar and an increase in BUN in females at 3,000 ppm (450 mg/kg/day, exceeding Category 2) were observed (Japanese Journal of Pesticide Science Vol. 13, No. 1 (Pesticide Science Society of Japan, 1988)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 96 hours LC50=0.89mg/L of the fish (Carp) (Agricultural Chemical Registration Data, 2005). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.69(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|