NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7292-16-2
Chemical Name	Dipropyl 4-(methylthio)phenyl phosphate
Substance ID	m-nite-7292-16-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	Since the flash point was 76 degC (testing method unknown), it was classified as Category 4 (GHS standards: flash point being more than 60 degC and 93 degC or less).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	Classification not possible due to lack of data, though the substance contains N-O bonds as chemical groups with explosive or self-reactive properties present	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Since the flash points is 76 degC, ignition temperature is judged to be 70 degC or more.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Since tests for such as water solubility and water soundness were performed (Agricultural Chemical Registration Data), it can be judged that it is stable in the water.	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on the rat LD50 values : 79.8mg/kg (male) and 72.5mg/kg (female) (Agricultural Chemical Registration Data), we adopted the lower value (LD50=72.5mg/kg) to classify the substance as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	It was set as Category 2, based on LD50 = 72.0mg/kg ( the lower value among rat male LD50 = 88.5mg/kg and female LD50 = 72.0mg/kg (Agricultural Chemical Registration Data)).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	It was set as Category 1 based on LC50 = 0.039mg/L on the both sex rat (Agricultural Chemical Registration Data).	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Since there was no data about an agricultural-chemicals field object, it was presupposed that it cannot classify.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Since there was no data about a pesticide ingredients, it was presupposed that it cannot classify.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Not classified	- -	-	-	By the skin sensitization study by the Maximization method in a guinea pig, based on a statement (Agricultural Chemical Registration Data) that a skin reaction was not accepted, it carried out the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although there is the description that it was negative in the chromosome aberration inducement test in the Chinese hamster cultured cell of in vitro and the reverse mutation test using the bacteria (Agricultural Chemical Registration Data), there is no result of human multi generation epidemiology, multi generation mutagenicity test, and germ cell in vivo mutagenicity test, the somatic cell in vivo mutagenicity test of in vitro. And there is no in vivo genotoxicity test of germ cell and somatic cell and there is no result of the multi index positive finding in in vitro mutagenicity test. So it cannot be classified	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Not classified	- -	-	-	It carried out the outside of Category based on the statement (Agricultural Chemical Registration Data) that frequency of these neoplastic increase in the incidence and be earlier relevant to administration were not acknowledged in the carcinogenicity test of rats and mice.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Not classified	- -	-	-	Based on the statement that although the general toxicity against parent animals was acknowledged in the three-generation reproduction study on rats and the reproductive toxicity examination on rats and rabbits, the effect on teratogenicity and reproductive potential was not acknowledged (Agricultural Chemical Registration Data). So it was set as the outside of Category.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (systemic, nervous system, lung, liver)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It was considered as Category 1 (systemicity, a nervous systems, lungs, liver) based on the description (Agricultural Chemical Registration Data ) that diminished spontaneous activity, tremor, salivation, dacryorrhea, blunting of outsaide responce, weakness like symptom, hematological adhesions of nasal periphery, bloody tears, the dirt of the abdomen, and downward recumbent position, the dirt of eyelids periphery, ataxia, respiration disorder, congestion or swelling of liver, distinguished blister formation in apicalus of pulmonary Clara cell at the dose within the range of guidance value in Category 1 (oral administration: 72.0-88.5mg/kg, inhalation (mist): 39.2 below mg/m3 ).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, liver)	Danger	H372	P260 P264 P270 P314 P501	Based on description that the decrease of serum cholinesterase activity and liver parenchymal cells diffuse fatty change degenerations were observed in the repeated administration study to a rat and a mouse with the given dose (0.5-10 mg/kg or less) of guidance value within the limits of Category 1 (Agricultural Chemical Registration Data), it was classified into Category 1 (nervous system, and liver).	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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