Item | Information |
---|---|
CAS RN | 74-88-4 |
Chemical Name | Methyl iodine |
Substance ID | m-nite-74-88-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2012)). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2012)). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2012)). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to low-temperature-boiling liquids are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 3 |
Danger |
H301 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on reports of LD50 values of 76 mg/kg (DFGOT vol. 7 (1996), IARC 41 (1986)) and 150-200 mg/kg (PATTY (6th, 2012)) for rats, it was classified in Category 3. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on an LD50 value of >2,000 mg/kg (male, female) for rabbits (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on an LC50 (4 hours) value of 232 ppm for rats (ACGIH (7th, 2001), DFGOT vol. 7 (1996)), it was classified in Category 2. Besides, the reference value in units of ppm was applied as a vapor without a mist because the LC50 value was lower than 90% of the saturated vapor concentration (532,895 ppm). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
There is a description that in a skin irritation test in which 0.5 mL of this substance was semi-occlusively applied to rabbits for 4 hours, the primary irritation index was 4.88, and it was moderately irritating (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). In addition, there is a report that erythema with vesicles was observed after 19 hours when 1 mL of this substance was applied to the skins of humans for 30 minutes (IARC 15 (1977)). From the above results, it was classified in Category 2. Besides, this substance was classified as "Xi; R38'' in the EU DSD classification and as "skin Irrit. 2 H315'' in the EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
This substance was classified in Category 2A because it is described that very severe eye irritation was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). It was classified based on the description of Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011) because public information about data in the previous classification was not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that no sensitization was observed in a skin sensitization test with guinea pigs (maximization method) (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), however, it was considered to be an insufficient data for use in classification because details of the test conditions and the results were unknown. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse bone marrow micronucleus test (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)) and positive in a DNA binding test with rats (liver, lung, stomach, forestomach) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). As for in vitro, there was a negative or positive result in a bacterial reverse mutation test and a mammalian cell gene mutation test (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), ACGIH (7th, 2001), PATTY (6th, 2012), DFGOT vol. 7 (1996), IARC 71 (1999)), and it was positive in a chromosomal aberration test with cultured mammalian cells (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was classified in Group 3 by IARC (IARC 71 (1999)). This IARC evaluation was not changed in the" IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, 2010" (HSDB (Access on September 2014)). NTP describes that this substance has not yet been evaluated for carcinogenicity (NTP Nomination Summary (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | In a two-generation reproductive study with rats by the inhalation route, no effects on fertility or pups were observed even at doses where parental toxicity (decreased body weight gain, decreased adrenal weight, degeneration of the olfactory epithelium, etc.) was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)), and in a teratogenicity study with rats by the inhalation route, fetotoxicity including teratogenicity was not observed in the fetuses at a dose where maternal toxicity (decreased body weight gain, decreased food consumption) was observed (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). It is described that in a teratogenicity study with rabbits by the inhalation route (inhalation exposure on gestational days 6-28), decreased maternal body weight gain and the reduced number of surviving fetuses with increased post implantation loss were observed, however, no effects on fertility or no teratogenicity was seen (Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). Therefore, it was classified as "Classification not possible." |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects) |
Danger Warning |
H370 H335 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance is respiratory tract irritating (ATSDR (2004)). In humans, nausea, vomiting, diarrhea, oliguria, lethargy, drowsiness, dizziness, unsteadiness during walking, ataxia, inability to carry out antagonistic movements in rapid succession (adiadochokinesia), unclear speech, visual disorders (such as double vision), delirium, severe and prolonged central nervous system injury, tremors, coma, etc. were reported in cases of poisoning in workers by inhalation (ACGIH (7th, 2001), DFGOT vol. 7 (1996), PATTY (6th, 2012)). In experimental animals, rats and mice showed narcosis (DFGOT vol. 7 (1996)), and decreased locomotor activity, sitting position with dropped head, ptosis, an increase in repetitive movements of the mouth and jaw, hunched position, gait disturbance and apathy for startle response, etc. in rats by inhalation at 25-400 ppm (0.15-2.32 mg/L) were observed as mainly high-dose symptoms. By the oral administration of 100-250 mg/kg to mice, piloerection, prostration, hypothermia, hypoactivity, abnormal breathing, hunched posture, unsteady gait, mydriasis and eyelid closure were observed (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012), Risk Assessment Report (Pesticides) (Food Safety Commission of Japan, 2011)). These findings in experimental animals were found within the range of doses corresponding to Category 1. In addition, there is a description that narcosis developed in rats and mice (DFGOT vol. 7 (1996)). From the above, it was considered that this substance may have an effect on the central nervous system as well as respiratory tract irritation and narcotic effects, therefore, it was classified in Category 1 (central nervous system), Category 3 (respiratory tract irritation, narcotic effects). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system), Category 2 (respiratory organs, thyroid) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
There is a description that a worker exposed at a manufacturing plant of this substance developed neurological symptoms such as vertigo, visual disturbances and weakness initially, followed by psychological disturbances and intellectual impairment (IARC 41 (1986)). In addition, there is a description that in workers or chemists who were repeatedly exposed by inhalation to the vapor of this substance, central and peripheral nervous system disorders such as lethargy, dizziness, nausea, unsteadiness during walking, adiadochokinesia, unclear speech, visual disorders were observed, and in cases with progressed symptoms, confusion, delirium and semi-comatose states were observed (DFGOT vol. 7 (1996)). As for experimental animals, in studies with rats exposed by inhalation to the vapor of this substance for 90 days or 1 year, degeneration of the olfactory epithelium in the nasal cavity was observed at concentrations of 70 ppm (0.41 mg/L/6 hours: corresponding to Category 2) and 60 ppm (0.36 mg/L/6 hours: corresponding to Category 2), respectively. In addition, by the 1-year exposure, effects on the thyroid (increased weight, cytoplasmic vacuolation and hyperplasia of the follicular epithelial cells) were seen at 60 ppm (0.35 mg/L/6 hours, corresponding to Category 2) (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). By the oral route, in a 90-day or 18-month feeding study with mice, and in a 12-month gavage (capsule) study with dogs, effects on the thyroid (findings similar to those observed in rats exposed by inhalation) were also observed within the dose range (equivalent to 8.0-26.8 mg/kg/day) corresponding to Category 1 or 2 (A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center, 2012)). From the above, by considering neurological disorders in humans and effects on experimental animals, it was classified in Category 1 (central nervous system), Category 2 (respiratory organs, thyroid). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2009 | GHS Classification Guidance by the Japanese Government (March, 2009) |
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