Item | Information |
---|---|
CAS RN | 74-90-8 |
Chemical Name | Hydrogen cyanide |
Substance ID | m-nite-74-90-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Flammable liquids | Category 1 |
Danger |
H224 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
The flash point is -18degC (c.c.) and the boiling point is 26degC (ICSC, 2003). Those containing stabilizers (water content: less than 3% by mass) are classified into Class 3 and Division 6.1 (UN#1051) by the UN Recommendations on the Transport of Dangerous Goods. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Containing no chemical groups with explosive or self-reactive properties | FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 538degC (ICSC, 2003) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to liquid substances are not available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) | FY2006 | GHS Classification Manual (10 Feb, 2006) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine and chlorine | FY2006 | GHS Classification Manual (10 Feb, 2006) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Classified as "liquid" according to GHS definition | FY2006 | GHS Classification Manual (10 Feb, 2006) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no "-O-O-" structure | FY2006 | GHS Classification Manual (10 Feb, 2006) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Those containing stabilizers (water content: less than 3% by mass) are classified into Class 3 and Division 6.1 (UN#1051) (UN Recommendations on the Transport of Dangerous Goods). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 1 |
Danger |
H300 | P301+P310 P264 P270 P321 P330 P405 P501 |
Based on the rat LD50 (oral route) value of 4.2mg/kg (CICAD 61 (2004)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Dermal) | Category 1 |
Danger |
H310 | P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501 |
Based on the rabbit LD50 (dermal route) value of 6.8mg/kg (CICAD 61 ( 2004)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on the rat LC50 value of 50.2ppm (4 hours), calculated from the testing data of rat LC50 (inhalation of vapour: GHS definition) of 142ppm (30 minutes) (CERI Hazard Data 2001-38 (2002)), was lower than 90% of the saturated vapour concentration (9,980ppm) under a saturated vapour pressure of 98.9kPa (742 mmHg, 25degC) (CERI Hazard Data 2001-38 (2002)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Clinical effects described in some case reports include "mild skin burns" in test animals (CICAD 61, 2004) and "skin irritation" in humans (HSDB, 2005). However, neither is the description of test results, and there is a provision that the substance "may be" irritating. Given these uncertainties, it was decided not to use these specific observations for classification. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
3 | Serious eye damage/eye irritation | Category 2A |
Warning |
H319 | P305+P351+P338 P337+P313 P264 P280 |
Clinical effects described in some human case reports include "IRRITATION OF EYE, CONJUNCTIVITIS" (HSDB, 2005); "There may also be irritation from skin and eye contact with the liquid" (HSDB, 2005)). However, neither is the description of test results, and the severity of effects is not provided. Although classified into Category 2A-2B, it should be placed in Category 2A from the viewpoint of safety, if further subclassification is needed. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no strong positive data on mutagenicity tests in vitro (several indices), described in CERI Hazard Data (2002) and CICAD 61 (2004). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Insufficient data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs, heart) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
Based on the human evidence including "coma" (HSDB (2000)), "dizziness, hypopnea, sense of instability, headache and nausea" (ACGIH (7th, 2001)), and the evidence from animal studies including "mild adverse effects on the central nervous system" (CICAD 61 (2004)), "dyspnea, bradycardia, arrhythmia, abnormal T wave during the diastolic period, clouding of consciousness and interruption of breathing, EEG fluctuations, dyspnea, coma, debility, gait disturbance and spasm" (CERI Hazard Data 2001-38 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. |
FY2006 | GHS Classification Manual (10 Feb, 2006) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (central nervous system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
Based on the human evidence including "abnormalities in the scores of long term memory, visual ability, visual learning, psychomotor functions" (CICAD 61 (2004)) and "headache, debility, dysgeusia and dysosmia" (IRIS (2002)). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available | FY2006 | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 96-hour LC50 = 0.0042 mg/L for crustacea (a species of Cancer irroratus) (Initial Risk Assessment Report, NITE, 2008), it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to unknown environmental dynamics of an inorganic compound, and 256-day NOEC = 0.0129 mg/L for fish (Pimephales promelas) (Initial Risk Assessment Report, NITE, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to unknown environmental dynamics of an inorganic compound, and 72-hour EC50 = 0.057 mg/L for algae (Nitzschia linearis) (Initial Risk Assessment Report, NITE, 2008), despite a low bioaccumulation estimate (log Kow = -0.25 (PHYSPROP Database, 2009)). It was classified in Category 1 from the above results. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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