NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	74-97-5
Chemical Name	Bromo(chloro)methane
Substance ID	m-nite-74-97-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (ICSC (J) (2013)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (ICSC (J) (2013)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (ICSC (J) (2013)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing chlorine (but not fluorine or oxygen) which is chemically bonded only to carbon or hydrogen.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	There is the information that it reacts violently with metals (sodium, potassium, magnesium, powdered aluminum, etc.) (ICSC (J) (2013)), but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reports of an LD50 value of 5,000 mg/kg for rats (HSDB (Access on August 2017)), and an LD50 value of 4,300 mg/kg for mice (ACGIH (7th, 2001), DFGOT vol. 25 (2009)), it was classified as "Not classified" (Category 5 in UN GHS classification).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of an LD50 value of > 5,000 mg/kg for rabbits (DFGOT vol. 25 (2009)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Category 4	Warning	H332	P304+P340 P261 P271 P312	Based on reports of LC50 values for mice of 2,300 ppm (converted 4-hour equivalent value: 3,043 ppm) (DFGOT Vol.25 (2009)) and 3,000 ppm (converted 4-hour equivalent value: 3,969 ppm) (ACGIH (7th, 2001)) in 7-hour inhalation exposure tests, and an LC50 value for mice of 2,043 ppm (converted 4-hour equivalent value: 2,889 ppm) in an 8-hour inhalation exposure test (DFGOT vol. 25 (2009)), it was classified in Category 4. Besides, the exposure concentrations are lower than 90% of the saturated vapor pressure concentration (187,412 ppm), therefore, a reference value in the unit of ppm was applied as vapor with little mist. The category was changed from the previous classification because new information sources were used.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	There is a description that contact with human skin causes irritation and burns, and long-term contact causes drying and cracking (HSDB (Access on August 2017)). As for rabbits, it is described that burns and denaturation were observed in a skin irritation test (HSDB (Access on August 2017)), and that tissue damage occurred in another occlusive application test, and degreasing of the skin was present in a non-occlusive application test (DFGOT vol. 25 (2009)). Therefore, it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2	Warning	H319	P305+P351+P338 P337+P313 P264 P280	It is described that by the application of this substance to the eyes of rabbits, marked edema of the conjunctiva and slight transient irritation of the cornea were observed (DFGOT vol. 25 (2009)), and it is also described that this substance was irritating to the eyes (PATTY (6th, 2012), HSDB (Access on August 2017)). Therefore, it was classified in Category 2. The category was changed based on the information obtained in this research.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. There is no in vivo data. As for in vitro, it was positive in the bacterial reverse mutation test, the mammalian cell chromosome aberration test, and the sister chromatid exchange test (ACGIH (7th, 2001), DFGOT vol. 25 (2009), NTP DB (Access on August 2017), IRIS (1991)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	There is no data on carcinogenicity of this substance in humans and in experimental animals, and EPA classified it as D (not classifiable as to human carcinogenicity) (IRIS (1991)). Therefore, it was classified as "Classification not possible." Besides, this substance is structurally similar to dichloromethane which is classified as B2 (probable human carcinogen) (IRIS (1991), PATTY (6th, 2012)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, out of 12 rats, 2 did not mate and 2 became sterilized at the maximum dose (300 mg/kg/day) at which general toxic effects on the liver, kidney, etc. were observed in male and female parental animals. Moreover, extension of the pregnancy period, high rate of stillbirth, low value of live birth index and a low value trend of the 4-day survival rate of the newborn pups were observed (JECDB (Access on August 2017)). In addition, it was described that as the result of inhalation exposure at 1,010 ppm for 114 days in male rabbits or guinea pigs, reduced spermatogenesis and tubular fibrosis in the testes occurred, but the number of animals used is insufficient to use for an evaluation (DFGOT Vol. 25 (2009)). From the above, since developmental effects were observed at the level where general toxicity occurred in maternal animals in the combined test with rats, it was classified in Category 2. Besides, classification became possible by using new information after the previous classification.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system), Category 3 (narcotic effects)	Danger Warning	H370 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As for humans, it was reported that during use of this substance as a fire extinguishing agent, three firefighters, who were exposed to the vapor or sprayed liquid of this substance for a short time, showed severe headache, nausea, burning sensation in the stomach, and vomiting, and hyperemia in the mucosa of the upper respiratory tract and conjunctiva were observed. There is a description as follows: in two out of the three firefighters, who were exposed close to the fire extinguishing point, disorientation, unconsciousness and generalized spasms etc. were observed and the other firefighter, who was exposed at some distance from the point, did not develop disorientation or unconsciousness but complained of headache for 3 months after the exposure; however, all three recovered (Environmental Risk Assessment for Chemical Substances Vol.6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008), ACGIH (7th, 2001), DFGOT vol. 25 (2009), PATTY (6th, 2012)). As for experimental animals, it was reported that in a 15-minute single inhalation exposure test with rats, hypersensitivity, an impaired sense of balance and convulsive tremors were observed at or above 1,500 ppm (DFGOT vol. 25 (2009)). In addition, it was described in ACGIH (7th, 2001) that in the same 15-minute inhalation exposure test with rats, a slight narcotic effect was observed at 3,000 ppm. From the above information on humans and experimental animals, it was classified in Category 1 (central nervous system) and in Category 3 (narcotic effects). Since generalized spasms were observed in humans, it was classified in Category 1 (central nervous system), and the classification result was different from the previous one.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)	Warning	H373	P260 P314 P501	No information on humans is available. As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, erosion of the glandular stomach, hypertrophy of the centrilobular hepatocytes, single cell necrosis and micro granuloma, etc. of hepatocytes were observed at or above 100 mg/kg/day (converted guidance value: 46.7 mg/kg/day), which is within the guidance value range for Category 2, and increases of relative weight of the liver, spleen, and adrenal gland, vacuolation of the adrenal fasciculata, vacuolation or necrosis of the proximal tubules, basophilic change of renal tubules and granulation of epithelial cell of the papillary duct in the kidney were reported at 300 mg/kg/day (converted guidance value: 140 mg/kg/day) which is beyond the guidance value range for Category 2 (JECDB (Access on August 2017)). In addition, several inhalation tests were performed, and effects were reported at doses exceeding the guidance value range of Category 2, but these doses were mostly the minimum dose for the test, and the effects at doses lower than the minimum dose were unknown (Environmental Risk Assessment for Chemical Substances Vol.6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). From the above, it was classified in Category 2 (liver). Besides, the classification result was different from the previous one due to the use of a new information source.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Reliable acute toxicity data were not obtained.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Category 1	Warning	H420	P502	This substance is listed in Annexes to the Montreal Protocol.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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