NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7440-66-6
Chemical Name	zinc powder - zinc dust (stabilized)
Substance ID	m-nite-7440-66-6_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Classification not possible	- -	-	-	Its powder or dust is rated UN No. 1436, and it is described in IMDGC to be "easily ignited, causing explosion". Its particle size and shape influence the result, so classification should be conducted according to the Note in UN document 2.7.2.4 by performing predetermined tests. Lump of zinc is considered to be "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Its autoignition point is 460degC (ICSC (1994), ICSC (J) (1994)), which is above 70degC.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Its powder or dust is rated UN No. 1436, and it is described in IMDGC to be "easily ignited, causing explosion". Its particle size and shape influence the result, so classification should be conducted according to the Note in UN document 2.7.2.4 by performing predetermined tests. Lump of zinc is considered to be "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Classification not possible	- -	-	-	Its powder or dust is rated UN No. 1436, and it is described in IMDGC to be "easily ignited, causing explosion". Its particle size and shape influence the result, so classification should be conducted according to the Note in UN document 2.7.2.4 by performing predetermined tests. Lump of zinc is considered to be "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Inorganic substance containing no oxygen, fluorine or chlorine	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic substance containing no bivalent -O-O- structure in the molecule	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	The substance is a solid with its melting point at 419.5degC (Merck (2006), Incompatible Hazard Handbook of Chemicals (Tokyo Fire Department), 1997). No proper testing methods for solid substances with melting points at 55degC or higher have been established.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on its LD50 > 2000 mg/kg for rats (OECD Guideline 401; Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on its LC50 > 5410 mg/m3 for rats (OECD Guideline 403; Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Not classified	- -	-	-	There is no available data on metallic zinc, but it is described that its effects are similar to those of zinc oxide. Since zinc oxide is not skin irritating (EU-RAR (2004)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Since the substance has been documented to be slightly irritating, showing such reactions as conjunctival redness and edema in a test using rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)), it was classified into Category 2B.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Not classified	- -	-	-	There is no available data on metallic zinc, but it is described that its effects are similar to those of zinc oxide. Since zinc oxide is not skin irritating (EU-RAR (2004)), the substance was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Due to a lack of epidemiological reports clarifying carcinogenicity, international organizations such as ACGIH (as of 2005), IARC (2005), EPA (2005), and NTP (2005) have not evaluated the carcinogenicity of zinc and its compounds (Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)). Thus, the substance was classified into "Classification not possible" due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Since there is no available data on metallic zinc, the substance was classified into "Classification not possible". Zinc is an essential trace element, and a lack thereof induces pathological dysfunctions, such as deficiency disorders and excess disorders including dermatitis, dysgeusia, diarrhea, and anemia. In humans, such cases as significant increase of pregnancy complications and reduced body weight in children born caused by reduced zinc concentration in blood have been reported (Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	In a test using rats, mild signs such as piloerection, diarrhea, bradypnea, and blepharospasm were seen, but the doses are unknown (Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)). In humans, symptoms such as lung symptoms including dyspnea, dry cough, and metal-fume fever caused by zinc fumes are seen (EHC (No. 221, 2001). However, since zinc fumes mainly consist of but zinc oxides rather than metallic zinc (EU-RAR (2004)), these symptoms are suggested to be caused by zinc oxides. Thus, the substance was classified into "Classification not possible" due to lack of data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	It is documented that in humans, after exposure at 124 mg/m3/50 months, cough and dyspnea (affecting the lungs and chest parts), after exposure at 2.4 mg/m3/5 years, normocytic anemia, and effects on bilirubin and cholesterol, and after exposure at 70 mg/kg/10 weeks, hematological changes and enzyme inhibition were observed (RTECS (2008)). However, since the document does not provide levels of symptoms and due to lack of data, the substance was classified into "Classification not possible". As relevant information, zinc is an essential trace element, and a lack thereof induces pathological dysfunctions, such as deficiency disorders and excess disorders including dermatitis, dysgeusia, diarrhea, and anemia (Initial Risk Assessment Report (NITE, CERI, NEDO) (2007)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Since its 72h-ErC50 = 0.15 mg/L for algae (Pseudokirchneriella subcapitata) (EHC (No. 221, 2001)), the substance was classified into Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	From acute toxicity Category 1 and for lack of rapid degradability judged from a metal, it was classified in Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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