Item | Information |
---|---|
CAS RN | 7440-74-6 |
Chemical Name | Indium |
Substance ID | m-nite-7440-74-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. Besides, it is written that powder indium is combustible (GESTIS (Access on May 2016)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It is estimated that it does not react vigorously with water due to the observation result of being insoluble in water (ICSC (2001)). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Indium is an element and an inorganic substance not containing oxygen or halogen. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic element. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the LD50 values of >2,000 mg/kg, 4,200 mg/kg for rats (PATTY (6th, 2012)), the substance was classified as "Not classified" (Category 5 in UN GHS classification). | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that indium and its compounds are irritating to the skin (HSDB (Access on June 2016)), however, it was not adopted for the evidence of the classification because this information source is equivalent to List 2 and the original source could not be confirmed. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Although it is described that indium is irritating to the eyes and the respiratory tract and that inhalation causes a cough and shortness of breath (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), it was not adopted for the evidence of the classification because this is considered to be a description on soluble indium compounds. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. No in vivo data are available. As for in vitro data, it is reported that both a bacterial reverse mutation test and a mammalian cell chromosomal aberration test were negative (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013), PATTY (6th, 2012)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | The substance was classified as "Classification not possible" due to lack of data because no data on carcinogenicity of this substance itself are available. Besides, as described in the same hazard class of the GHS classification of indium oxide (CAS 1312-43-2), carcinogenicity classifications by other organizations of related compounds are Group 2A for indium phosphide by IARC (IARC 86 (2006)) and Group 2A for indium and compounds (inorganic, hardly soluble) by the Japan Society For Occupational Health (JSOH) (Recommendation of Occupational Exposure Limits (2015)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that in inhalation developmental toxicity studies using rats or mice exposed by inhalation to indium phosphide during gestation, early deaths and reduced weight gain of maternal animals and no fetal malformation were observed at high concentration (100 mg/m3) in mice, while no severe effects on both maternal animals and the fetuses were observed in rats (NTP TR499 (2001)). In contrast, it is described that in the study using rats with a single intravenous dose of indium trichloride on Day 9 of gestation, malformations of the tail and digits were observed (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), and that in a study using rats given indium trichloride by gavage administration during the organogenesis period (Day 6 to 15 of gestation), increases in the external, visceral and skeletal malformations were observed (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is described that indium is irritating to the respiratory tract (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)), however, the source of this information is ICSC and the original article cannot be confirmed. Moreover, it is not clear whether this description is about metallic indium or indium compounds . Therefore, it was not adopted as evidence of the classification because it is considered that this information alone is insufficient for the evidence of classification. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | As for experimental animals, in a 28-day repeated dose toxicity study by oral administration, no adverse effects were observed at 1,000 mg/kg/day (Environmental Risk Assessment for Chemical Substances Vol. 11 (Ministry of the Environment, 2013)). No information on the inhalation route was available. Besides, there are reports of interstitial pneumonia caused by inhalation of indium tin compounds and indium oxide in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), OEL Documentations (2007) and Recommendation of Occupational Exposure Limits, Vol. 55, 2013 (Japan Society For Occupational Health (JSOH)). In the previous classification, based on the descriptions in ACGIH (7th, 2001) etc. such as "TLV-TWA for indium and its compounds were set up due to skeletal and gastrointestinal effects, and particularly pulmonary toxicity by inhalation into the lung," skeleton and digestive system as well as respiratory organs were determined as target organs. However, because the information was based on the preliminary investigation on indium compounds exposure by the EPA, it is thought to be not reliable due to being a preliminary survey and no information other than symptom names based on complaints, and the information was not adopted for the evidence of classification. Therefore, the substance was classified as "Classification not possible" due to lack of data. |
FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2016 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
|