NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7446-19-7
Chemical Name	Zinc sulfate monohydrate
Substance ID	m-nite-7446-19-7_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	The anhydrate: not combustible (ICSC (2004)) The not combustible: not combustible (ICSC (2001))	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	The anhydrate: not combustible (ICSC (2004)) The not combustible: not combustible (ICSC (2001))	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	The anhydrate: not combustible (ICSC (2004)) The not combustible: not combustible (ICSC (2001))	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From the information of being soluble in water (Merck (2006)), it is recognized that it does not react vigorously with water.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	For zinc sulfate heptahydrate (CAS: 7446-20-0), there is a report on LD50 = 1,000-2,000 mg/kg (EU-RAR (2004)), 1,757.17 mg/kg (males), and 1,229.27 mg/kg (females) (Japan Crop Protection Association (1994)) for rats. When these values were converted to zinc sulfate monohydrate, they were LD50 = 624.1- 1,248.2 mg/kg bw, 1096.6 mg/kg (males), and 767.2 mg/kg (females), and it was classified in Category 4. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, for zinc sulfate heptahydrate (CAS: 7446-20-0), LD50 > 2,000 mg/kg bw for rats is reported (EU-RAR (2004)). When this value was converted to zinc sulfate anhydrate, it was LD50 > 1,248 mg/kg bw. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Vapour exposure is thought to be difficult because it is described in NITE CHRIP (2012) that the vapour pressure of zinc sulfate heptahydrate (CAS: 7446-20-0) is "practically 0 mmHg." It was thought to be similar for zinc sulfate monohydrate, therefore, it was classified as "Not applicable." [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	In a primary skin irritation test with rabbits (according to Directive 92/69/EEC B.4 and OECD guideline 404) on zinc sulfate heptahydrate (CAS: 7446-20-0), as a result of 4-hour semi-occlusive application of 0.5 g of this substance to the auricle, no irritation was observed (EU-RAR (2004)). Furthermore, in another primary skin irritation test with rabbits on zinc sulfate heptahydrate, after 0.5 g of this substance was applied to two sites of the dorsal skin (normal skin and abraded skin) for 4 hours, no skin reactions were observed in normal skin or abraded skin (Japan Crop Protection Association (1994)). Moreover, it is described in EU-RAR (2004) that zinc sulfate heptahydrate is not corrosive to the skin, and it is concluded that based on the test according to EU and OECD guidelines, zinc sulfate is considered not irritating/corrosive to the skin. Based on the above information, it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In an eye irritation/corrosion test with rabbits (according to Directive 92/69/EEC B.5 and OECD guideline 405) on zinc sulfate heptahydrate (CAS: 7446-20-0), corneal injury, conjunctival redness, chemosis, and eye discharge were observed. Yellow/white spots were found in the tissue of the lower eyelid, nictitating membrane, and/or sclera from 7 days after application, and none of these were reversible during the test period (EU-RAR (2004)). It is described in EU-RAR (2004) that these spots were signs of necrosis, and according to EU criteria, this substance is considered to cause severe ocular irritation and should be labelled as R41. Besides, zinc sulfate is classified in "R41" in EU DSD classification and "Eye dam. 1" in EU CLP classification. Based on the above information, it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Most information on zinc sulfate has no description of the anhydrate or hydrate, and there are no data in which the monohydrate is mentioned. Besides, the information on the anhydrate is limited to a positive result in an in-vivo comet assay with mice (NITE (2008)). And as the in vivo information on zinc sulfate (no description of the anhydrate or hydrate), there are negative results in all of a chromosomal aberration test, a micronucleus test, and a dominant lethal test (NITE (2008), EU-RAR (2004), ATSDR (2009), EHC (2001), IUCLID (2000), HSDB (2006)). Furthermore, as the in vitro information on zinc sulfate (no description of the anhydrate or hydrate), it was negative in a bacterial reverse mutation test (NITE (2008), EU-RAR (2004), ATSDR (2009), EHC (2001), IUCLID (2000), HSDB (2006)) and a chromosomal aberration test with cultured mammalian cells (NITE (2008), EU-RAR (2004), IUCLID (2000), HSDB (2006)) and positive in an HGPRT gene mutation test with cultured mammalian cells (IUCLID, 2000). [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" due to no classification results by other organizations or toxicity information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results on zinc sulfate heptahydrate (CAS RN 7446-20-0) and zinc sulfate, the anhydrate of this substance (CAS RN 7733-02-0).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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