NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7446-20-0
Chemical Name	Zinc sulfate heptahydrate
Substance ID	m-nite-7446-20-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (2001)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified	- -	-	-	Not combustible (ICSC (2001)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2001)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	From information on water solubility: 54 g/100 mL (20 deg C) (ICSC (2001)), it is recognized that it does not react vigorously with water.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Classification not possible	- -	-	-	The classification was not possible due to no data from the prescribed test.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified in Category 4 from LD50 = 1,000-2,000 mg/kg bw (EU-RAR (2004)), 1,757.17 mg/kg (males), 1,229.27 mg/kg (females) (Japan Crop Protection Association (1994)) for rats. [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" from LD50 > 2,000 mg/kg bw for rats (EU-RAR (2004)). The category was changed by adding data in EU-RAR (2004) obtained in this investigation. [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Vapour exposure was thought to be difficult because there is a description of practically 0 mmHg for vapour pressure in the NITE Chemical Risk Information Platform (NITE-CHRIP, 2012). Therefore, it was classified as "Not applicable." [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	In a primary skin irritation test with rabbits (according to Directive 92/69/EEC B.4 and OECD guideline 404), no irritation was observed after a 4-hour semi-occlusive application of 0.5 g of this substance to the auricle (EU-RAR (2004)). And in another primary skin irritation test with rabbits, after 0.5 g of this substance was applied to two sites (normal and abraded skin) of the dorsal skin for 4 hours, no skin reactions were observed in either normal or abraded skin (Japan Crop Protection Association (1994)). Furthermore, it is described in EU-RAR (2004) that this substance is not corrosive to the skin, and it is concluded that zinc sulfate is considered not irritating/corrosive to the skin based on the test according to EU and OECD guidelines. It was classified as "Not classified" based on the above information. The classification was conducted based on data in List 1 (EU-RAR (2004)) and List 2 (Japan Crop Protection Association (1994)) obtained in this investigation. [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In an eye irritation/corrosion test with rabbits (according to Directive 92/69/EEC B.5 and OECD guideline 405), corneal injury, conjunctival redness, chemosis, and discharge were observed. Yellow/white spots were found in the tissue of the lower eyelid, nictitating membrane, and/or sclera from seven days after application, and they did not disappear during the test period (EU-RAR (2004)). It is described in EU-RAR (2004) that these yellow/white spots are signs of necrosis, this substance is considered to induce severe ocular irritation, and it should be labelled as R41 according to EC criteria. It was classified in Category 1 based on the above information. The classification was conducted based on data in List 1 (EU-RAR (2004)) obtained in this investigation. [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Not classified	- -	-	-	In a skin sensitization test with guinea pigs (a maximization test according to Directive 96/54/EC B.6 and OECD TG 406), it was negative after induction by intradermal administration of a 0.1% aqueous solution of this substance followed by dermal application of a 50% aqueous solution, and challenge by dermal application of a 50% aqueous solution (EU-RAR (2004)). Furthermore, in another skin sensitization test with guinea pigs (a maximization test), it is described that all animals in the positive control group showed erythema, eschar, and edema, and clear positive response, but no skin reactions were observed in the test group and the negative control group at any observation points (Japan Crop Protection Association (1994)). Moreover, it is concluded in EU-RAR (2004) that this substance is not considered a skin sensitizer. It was classified as "Not classified" based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Most information on zinc sulfate has no description of anhydrate or hydrate, and there are no data with a clear description of the heptahydrate. Besides, the information with a description of anhydrate is limited to a positive result in an in vivo comet assay with mice (NITE (2008)). Besides, as for in vivo information on zinc sulfate (no description of anhydrate or hydrate), there are negative results in all of a chromosomal aberration test, a micronucleus test, and a dominant lethal test (NITE (2008), EU-RAR (2004), ATSDR (2009), EHC (2001), IUCLID (2000), HSDB (2006)). Furthermore, as for in vitro information on zinc sulfate (no description of anhydrate or hydrate), it was negative in a bacterial reverse mutation test (NITE (2008), EU-RAR (2004), ATSDR (2009), EHC (2001), IUCLID (2000), HSDB (2006)) and a chromosomal aberration test with cultured mammalian cells (NITE (2008), EU-RAR (2004), IUCLID (2000), HSDB (2006)), and positive in an HGPRT gene mutation test with cultured mammalian cells (IUCLID (2000)). [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because there are no classification results by other organizations or toxicity information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. [Note] Please also refer to the classification results for zinc sulfate monohydrate (CAS RN 7446-19-7) and zinc sulfate (CAS RN 7733-02-0), which is the anhydrate of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 2 (gastrointestinal tract)	Warning	H371	P308+P311 P260 P264 P270 P405 P501	In an acute toxicity test (OECD TG 423) with rats by oral administration, 2/6 animals died at 2,000 mg/kg, and macroscopic changes in the gastrointestinal tract such as thickened gastric mucosa and hemorrhagic small intestine were observed in dead animals (EU-RAR (2004)). Therefore, it was classified in Category 2 (gastrointestinal tract).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. As for information on animal tests in the oral route, doses at which toxicity occurred were 2,486-2,514 mg/kg/day for rats and 4,878-4,927 mg/kg/day for mice, higher than 100 mg/kg/day, the upper limit of guidance values (NITE (2008), EU-RAR (2004)), therefore it corresponds to "Not classified." However, because of insufficient information on the other routes, it was classified as "Classification not possible" due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	From 96-hour LC50 = 0.095 mg/L for crustacea (Ceriodaphnia affinis/dubia) (ECETOC TR91, 2003), it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to unknown behavior of the metal compound in water, and 8-month NOEC = 0.343 mg/L for fish (Oncorhynchus mykiss) (EU-RAR, 2010). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to unknown behavior of the metal compound in water, and 96-hour LC50 = 0.095 mg/L for crustacea (Ceriodaphnia affinis/dubia) (ECETOC TR91, 2003). By drawing a comparison between the above results, it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information