Item | Information |
---|---|
CAS RN | 7488-55-3 |
Chemical Name | Tin sulphate |
Substance ID | m-nite-7488-55-3_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Flammable solids | Not classified |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on July 2019)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on July 2019)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on July 2019)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility information of 18.8 g/100 mL (CRC (98th, 2017)). | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound containing oxygen (but not halogen). However, the classification is not possible due to no data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound. It was classified as "Not classified (Not applicable)." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
17 | Desensitized explosives | Not classified |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1), it was classified as "Not classified." The category was changed from the previous classification by using the new information source. [Evidence Data] (1) LD50 for rats: 2,207 mg/kg (REACH registration dossier (Access on September 2019)) |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified (Not applicable)." |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
[Rationale for the Classification] From (1), it does not correspond to Category 1, and based on (2), it was classified in Category 2. Besides, the category was changed since new data were available. [Evidence Data] (1) In an in vitro skin corrosion test with human skin model according to OECD TG 431, the tissue viability after 3- and 60-minute exposure was 95% and 79%, respectively (REACH registration dossier (Access on September 2019)). (2) Inorganic tin compounds are irritating to the eyes and skin (HSDB (Access on August 2019)). [Reference Data, etc.] (3) It was classified in "Skin Irrit. 2 (H315)" in the EU CLP classification (EU CLP classification (Access on September 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 1. Besides, the category was changed since new data were available. [Evidence Data] (1) The pH of a 2.5% solution of this substance is described to be less than 2 (REACH registration dossier (Access on September 2019)). (2) Inorganic tin compounds are irritating to the eyes and skin (HSDB (Access on August 2019)). [Reference Data, etc.] (3) It was classified in "Eye Dam. 1 (H318)" in the EU CLP classification (EU CLP classification (Access on September 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
[Rationale for the Classification] Based on (1), it was classified in Category 1. The category was changed since new data were available. [Evidence Data] (1) Divalent tin compounds are reported to be positive in a human patch test (REACH registration dossier (Access on September 2019)). [Reference Data, etc.] (2) It was classified in "Skin Sens. 1 (H317)" in the EU-CLP classification (EU CLP classification (Access on September 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] Although there is no information on this substance itself, from (1), it was judged that classification based on the information on soluble stannous compounds was possible. Based on (2) and (3), it was classified as "Not classified." [Evidence Data] (1) There is a description that this substance is an inorganic tin compound, which is quite soluble in water (solubility of 188 g/L) (CRC (98th, 2017)). (2) As for in vivo tests with soluble stannous compounds, there are negative reports in micronucleus tests with mice using tin(II) chloride (CAS RN 7772-99-8) and tin(II) fluoride (CAS RN 7783-47-3) (CICAD 65 (2008)). (3) As for in vitro tests with soluble stannous compounds, there are negative reports in bacterial reverse mutation tests using tin(II) chloride (CAS RN 7772-99-8) and tin(II) fluoride (CAS RN 7783-47-3)and in a chromosomal aberration test with cultured mammalian cells using stannous chloride (CAS RN 7772-99-8) (CICAD 65 (2008)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] Limited in nature but available experimental animal studies with tin compounds have not shown tin metal, tin (II) chloride or a small number of other tin compounds to be carcinogenic (CICAD 65 (2005)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) Only limited data were identified on the reproductive and developmental toxicity of inorganic tin compounds. No adverse effects were found in rats when tin was given in the diet for three generations or when some tin compounds were given in the diet throughout pregnancy. Similarly, repeated gavage treatment of pregnant rats, mice, and hamsters with tin (II) chloride was without adverse effect on the fetuses (CICAD 65 (2005)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1)-(3), it was classified in Category 3 (respiratory tract irritation). [Evidence Data] (1) There is a description that this substance is an inorganic tin compound, which is quite soluble in water (solubility of 188 g/L) (CRC (98th, 2017)). (2) There is a description that inorganic tin compounds can irritate the nose and throat (HSDB (Access on August 2019)). (3) The pH of a 2.5% solution of this substance is described to be less than 2 (REACH registration dossier (Access on October 2019)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (lung), Category 2 (liver, blood system) |
Danger Warning |
H372 H373 |
P260 P264 P270 P314 P501 |
[Rationale for the Classification] Based on (1), effects on lungs in humans may occur by inhalation exposure to metal tin and inorganic tin compounds, and based on (2), effects on the liver and blood system were observed within the range of Category 2 by oral administration to rats, therefore, it was classified in Category 1 (lung), category 2 (liver, blood system). [Evidence Data] (1) The ACGIH recommends Threshold Limit Values in the workplace (TLV-TWA of 2 mg/m3 as inhalable particulate matter) for elemental tin, tin oxides and tin inorganic compounds (except tin hydride and indium tin oxide) in order to prevent stannosis (ACGIH (7th, 2019)). (2) In a 4-week feeding study with rats, decreased hemoglobin and hematocrit were observed at or above 83 mg/kg/day (converted guidance value: 26 mg/kg/day, within the range of Category 2), and decreased liver weight, homogenous hepatocyte cytoplasm and bile duct hyperplasia were observed at 275 mg/kg/day (converted guidance value: 86 mg/kg/day, within the range of Category 2) (ATSDR (2005), CICAD 65 (2005), EHC 15 (1980), de Groot et al. (1973)). |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2019 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
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