Item | Information |
---|---|
CAS RN | 7496-02-8 |
Chemical Name | 6-Nitrochrysene |
Substance ID | m-nite-7496-02-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | It contains chemical groups (nitro group) associated with explosive properties and its oxygen balance is calculated to be -231. Based on this information, the substance was classified into the "Not classified" category. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
8 | Self-reactive substances and mixtures | Classification not possible |
- |
- | - | It contains chemical groups (nitro group) associated with explosive properties. Since no test results are available, classification is not possible. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
10 | Pyrophoric solids | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an organic compound containing oxygen (but not fluorine or chlorine), which is chemically bonded to nitrogen. Since no test results based on standardized testing methods are available, classification is not possible. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Since the substance is a solid (GHS definition), it was classified into the "Not applicable" category. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
In vivo micronucleus assay using mouse bone marrow cells gave positive results (EHC 229 2003). Since there are no in vivo genotoxicity test results available, the substance was classified into Category 2. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
6 | Carcinogenicity | Category 1B |
Danger |
H350 | P308+P313 P201 P202 P280 P405 P501 |
[Rationale for the Classification] As for carcinogenicity, there is no available report in humans. Based on the IARC's classification result (1) and test results of (2), (3), it was classified in Category 1B. The category was revised as the result of reviewing the previous classification due to the revision of the classification in 2014 by IARC. [Evidence Data] (1) IARC classified it in Group 2A by stating that there is sufficient evidence in experimental animals for carcinogenicity and by considering mechanism and so on (IARC 105 (2014)). Besides, Japan Society for Occupational Health (JSOH) also classified it in Group 2A (OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)). Other than these, NTP classified it in R (NTP RoC (14th, 2014)). (2) In a test in which female rats were orally dosed for eight weeks (once/week), mammary gland carcinoma increased after 23 weeks (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)). (3) In an initiation-promotion test in which mice were given applications of ten times on the skin followed by an application of TPA (12-o-tetradecanoylphorbol 13-acetate) as a promoter, squamous cell papilloma increased (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)). [Reference Data, etc.] (4) In a test in which newborn mice were given three intraperitoneal doses, lung tumors increased 26 weeks after the doses (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)). (5) In a test in which newborn mice were given three intraperitoneal doses, liver adenoma and adenocarcinoma and malignant lymphoma increased one year after the doses (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)). (6) In a test in which mice were given intraperitoneal administration (once), liver tumors. lung tumors, and malignant lymphoma increased one year after the dose (IARC 105 (2014), OEL Documentations (Carcinogenicity classification) (Japan Society For Occupational Health (JSOH) 2016)). (7) There is strong mechanistic evidence to support the carcinogenicity of this substance: in vitro, this substance is metabolized in the human tissues of the liver, lung, and mammary gland to form reactive metabolites that cause DNA damage; the substance produces DNA adducts (IARC 105 (2014)). |
FY2018 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2007 | GHS Classification Manual (10 Feb, 2006)/Technical Guidance Document on the GHS Classification (6 Dec, 2005) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
|