Item | Information |
---|---|
CAS RN | 75-38-7 |
Chemical Name | Vinylidene dibromide |
Substance ID | m-nite-75-38-7_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
From explosion limit (5.5-21.3% (ICSC (1997))), it was classified in Category 1. Besides, it is classified in Division 2.1 (UN1959) in UNRTDG. There is a group that indicates chemical instability, but information on test results was not obtained. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It is a flammable gas classified in Division 2.1 in UNRTDG. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | High pressure liquefied gas |
Warning |
H280 | P410+P403 | From a critical temperature (29.75 deg C (HSDB (Access on July 2013))) between -50 deg C and +65 deg C, it was classfied as liquefied gas (high pressure liquefied gas) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | It was classified as "Not classified" because a non-lethal dose (converted 4-hour equivalent value: 100,000 ppm) for rats after inhalation exceeded 5,000 ppm (SIDS (2001)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | A skin irritation test was not conducted because it is a gas, but other toxicity test results indicate that it does not irritate the skin (SIDS (2001)). Therefore, it was classified as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | Data in an eye irritation test were not obtained, but results of acute, repeated, and long-term inhalation exposure tests indicate that it does not irritate the eye (SIDS (2001)). Therefore, it was classified as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, a negative result in a micronucleus test with mice is described (IUCLID (2000)). On the other hand, as for in vitro, there are reports on an equivocal result (IARC 71 (1999)), a negative result (ACGIH (7th, 2001), IUCLID (2000)), and a positive result (NTP DB (Access on June 2013), ACGIH (7th, 2001), IUCLID (2000)) in bacterial reverse mutation tests, but it was negative in an in-vitro chromosomal aberration test and an hprt gene mutation test with cultured mammalian cells. Based on the obtained knowledge, this substance does not present a genotoxic hazard to humans (SIDS (2001)), or it is considered that this substance does not significantly interfere with the genome (ECETOC (2005)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in Group 3 by IARC (IARC 71 (1999)) and A4 by ACGIH (ACGIH (7th, 2001)). The category was changed according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It is described in SIDS (2001), ECETOC (2005) that in a 13-week inhalation exposure test with male rats, microscopic examination of the testis and epididymis revealed impaired spermatogenesis in mid and high dose groups (7,000, 40,000 ppm, 6 hours/day) (Appleman et al., 1985). On the other hand, it was not reproducible in another test (Reuzel et al. 1986) (in a 13-week inhalation exposure test with three doses including maximum 7,000 ppm, 6 hours/day, there were no changes macroscopically or histopathologically in the testis and epididymis in weanlings or young adults, sperm concentrations, the number of sperm cells with deformed heads/tails, and the number of isolated heads/tails did not increase, and a no-observed-effect concentration (NOEC) was 7,000 ppm for the fertility effects), and contradicting results on male fertility are reported. Other than the above, no exposure effects of the test substance were observed in either a test by inhalation exposure before mating and during the first trimester of gestation or a test by inhalation exposure during the period of fetal organogenesis (SIDS (2001), ECETOC (2005)). From the above results, because it is unknown whether there are effects on male fertility, it was classified as "Classification not possible." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
It is described that in tests with rats and mice by single inhalation exposure to a gas, central nervous effects or behavioral changes (unsteady gait) via the central nervous system were observed at high concentrations of 200,000 ppm (1 hour) to 800,000 ppm (-19 hours) (ACGIH (7th, 2001), SIDS (2001), ECETOC (2005)). Therefore, it was classified in Category 3 (narcotic effects). Besides, there are no reports on health effects in humans. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Not classified |
- |
- | - | In 2-week or 13-week inhalation exposure tests with rats and mice, no effects or only slight effects on the respiratory organs and central nervous system were observed even at the high concentrations above the guidance values for Category 2 (SIDS (2001), ACGIH (7th, 2001)). Although there is no toxicity information on the other routes, this substance was classified as "Not classified" based on the test results in the inhalation route only because it is a gas according to GHS definition, and exposure is normally in the inhalation route. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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