NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	75-59-2
Chemical Name	Tetramethylammonium hydroxide
Substance ID	m-nite-75-59-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an ignition point of 470 degrees C (GESTIS (Access on Dec. 2011)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for solid substances with a melting point of 140 degrees C or lower.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	An organic compound does not contain fluorine or chlorine but contains oxygen which is not chemically bonded to elements other than carbon or hydrogen.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances. Besides, there is the information that this substance is corrosive to aluminum, tin, bronze, and zinc (Hommel (1996)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 2	Danger	H300	P301+P310 P264 P270 P321 P330 P405 P501	From an LD50 value of 34 to 50 mg/kg bw for rats (Report on Toxicity Tests of Chemical Substances, MHLW (2000)), it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Category 2	Danger	H310	P302+P352 P361+P364 P262 P264 P270 P280 P310 P321 P405 P501	From an LD50 value of 112 mg/kg bw for rats (SIAP (2006)), it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Edema, necrosis with severe erythema and hemorrhage were observed 24 hours after occlusive application of a pentahydrate of this substance moistened by water at doses of 25 to 1000 mg/kg to guinea pig skin and it was concluded to be "extremely severe corrosive irritant" to skin (SIAP (2006)). From the information, it was classified in Category 1. Besides, this substance is strong alkaline whose pH is 13.61 in a 10% aqueous solution (SIAP (2006)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Because the pH of this substance is 13.61 in a 10% aqueous solution (SIAP (2006)) and a test using guinea pigs concluded that a pentahydrate of this substance was "extremely severe corrosive irritant" to skin (SIAP (2006)), it was classified in Category 1.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, both an Ames test (OECD TG471, GLP) and a chromosomal aberration test using Chinese hamster CHL cells (OECD TG 473, GLP) reported negatives as in vitro tests (Report on Toxicity Tests of Chemical Substances, MHLW (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	As a result of an oral administration reproductive/developmental toxicity screening test in rats (OECD TG421, GLP), it was reported that general toxicity in parent animals in a high dose group such as decreases in food consumption and locomotor activity, incomplete eyelid opening/eyelid closure, decreased body weights were observed. But effects on reproductive parameters of days required for copulation, copulation index, fertility index, implantation index, gestation length, and delivery index were not observed. And effects on numbers of total offspring and live offspring, sex ratio, live birth index, and viability index, and external abnormality in neonates were not observed (SIAP (2006)). But it was classified as "Classification not possible" due to insufficient data on adverse effects on the development of the offspring including teratogenicity.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	As a result of an acute oral toxicity test using rats (doses: 10, 15, 23, 34, 50 mg/kg (males), 23 mg/kg (females); OECD TG401, GLP), deaths at 34 mg/kg or higher and signs of a decrease in locomotor activity, hypothermia, incomplete eyelid opening/eyelid closure, ataxic gait, clonic convulsions, salivation, and bradypnea at 23 mg/kg or higher were observed. And an LD50 value of 34 to 50 mg/kg bw (males) was reported (Report on Toxicity Tests of Chemical Substances, MHLW (2000)). And as a result of an acute dermal toxicity test using rats (doses: 50, 100, 125 mg/kg (females), 100 mg/kg (males): GLP compliance), signs of a decrease in locomotor activity, irregular respiration, narrow palpebral fissure, and tonic-clonic convulsions were observed. And an LD50 value of 112 mg/kg (females) was reported. (SIAP (2006)). From signs such as ataxic gait, clonic convulsions, and salivation at 23 mg/kg in oral exposure and a sign of tonic-clonic convulsions at 100 mg/kg in dermal exposure in the above reports, it was classified in Category 1 (nervous system).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)	Danger	H372	P260 P264 P270 P314 P501	As a result of a repeated dose 28-day oral toxicity test using rats (doses: 5, 10, 20 mg/kg/day) (OECD TG 407, GLP), a sign of salivation at 10 mg/kg/day (converted to a 90-day equivalent: 3.1 mg/kg/day) or higher was observed. And a dose-dependent decrease in heart weight at 5 mg/kg/day in males (converted to a 90-day equivalent: 1.55 mg/kg/day) or higher but histopathological changes were not observed. (Report on Toxicity Tests of Chemical Substances, MHLW (2000)) In addition, as a result of a 28-day repeated dermal administration toxicity test using rats (doses: males 5.5, 50, 120, 250 mg/kg/day, females 2.5, 5.5, 10, 50 mg/kg/day: OECD TG 410), convulsions and tremors followed by signs of lethargy were shown. And deaths at 50 mg/kg/day (converted to a 90-day equivalent: 15.5 mg/kg/day) or higher but no deaths and no clear toxic signs at 10 mg/kg/day or lower were observed. (SIAP (2006)) Because salvation, convulsions, and tremors were observed within a range of Category 1 in Guidance values in both oral and dermal routes in the above reports, it was classified in Category 1 (nervous system).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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