NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	75-66-1
Chemical Name	tert-Butyl mercaptan
Substance ID	m-nite-75-66-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Category 2	Danger	H225	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	Based on a flash point of -26 deg C (closed cup), and a boiling point of 64 deg C (ICSC (J) (2004)), it was classified in Category 2. Besides, it is classified in Class 3, PGII in UNRTDG (UN 2347).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 253 deg C (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Organic compounds containing no oxygen, fluorine or chlorine	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a report of an LD50 value for rats of 4,729 mg/kg (SIDS (2012), PATTY (6th, 2012)), it was classified as "Not classified" (Category 5 in UN GHS classification).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on the report of an LD50 value of > 2,000 mg/kg for rabbits (SIDS (2012)), it was classified as "Not classified."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	Based on reports of LC50 values of 22,000 ppm and 26,643 ppm in 4-hour inhalation exposure tests with rats (SIDS (2012), PATTY (6th, 2012)), it was classified as "Not classified." Besides, since the LC50 values were lower than the 90% of saturated vapour concentration (238,884 ppm), a reference value in the unit of ppm was applied as vapour with little mist.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Not classified	- -	-	-	As for a 4-hour application in skin irritation tests (corresponding to OECD TG 404 and OPPTS 870.2500), it is reported that it was mildly irritating (SIDS (2012)) and that it was not irritating (ECHA registration dossier (Access on December 2017)). Also, there are descriptions that mild irritation was observed in the 24-hour application test (SIDS (2012)), and that mild irritation or mild erythema and discoloration at the application site were observed although the application time was unknown (PATTY (6th, 2012)). Therefore, this substance was considered to have mild irritancy and it was classified as "Not Classified" (Category 3 in UN GHS classification), to which "mild irritation" is considered to correspond in the GHS classification guidance for Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	It is described that in an eye irritation test using rabbits (compliant with OECD TG 405), eye irritation was observed in all the animals after an application but resolved within 7 days, and it was considered to be mildly irritating to the eyes (ECHA registration dossier (Access on December 2017)), and that mild eye irritation was shown in the other multiple tests with rabbits (SIDS (2012), HSDB (Access on August 2017)), therefore, it was classified in Category 2B.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	It is described that in a skin sensitization test with guinea pigs, all of the test animals showed a score of 1-3 on skin findings (redness, edema) after 24 or 48 hours, and it is a sensitizing substance (SIDS (2012)), and that in a skin sensitization test by the LLNA method with mice (according to OECD TG 429), the SI values were greater than 3 at concentrations of 25%, 50% and 100%, and this substance was found to be sensitizing (ECHA registration dossier (Access on December 2017)). Therefore, it was classified in Category 1.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2012)), and as for in vitro, it was negative in a bacterial reverse mutation test, positive and negative results in a mouse lymphoma test with mammalian cultured cells, negative in a sister chromatid exchange test (SIDS (2012), HSDB (Access on August 2017)). From the above, it was classified as "Classification not possible" according to the GHS classification guidance for the Japanese government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Classification not possible	- -	-	-	In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, in the high dose group (200mg/kg/day), in which apparent general toxic effects (reduced body weight gain, effects on the liver, kidney, haemal system etc.) were observed in parent animals, a slight effect (low body weight at day 4 after birth) was observed in pups born, but no other reproductive/developmental effects were observed (JECDB (Access on August 2017), SIDS (2012)). Furthermore, in developmental toxicity tests where pregnant rats or mice were exposed by inhalation at up to 200 ppm (6 hours/day: gestation days of 6-19 (rats), gestation days of 6-16 (mice)), neither the maternal animals nor fetuses showed effects due to exposure to this substance even at the highest concentration (SIDS (2012)). From the above, both a reproduction/developmental toxicity screening test with rats by the oral route and developmental toxicity tests with rats and mice by the inhalation route resulted in negative in reproductive/developmental toxicity. However, the oral administration test is a screening test, and in the developmental toxicity tests by the inhalation route, animals were not exposed at up to the concentration at which general toxic effects appeared in maternal animals, and the dose was thought to be insufficient to conclude that it is negative, and it is not possible to classify as "Not classified" only by these results, therefore, it was classified as "Classification not possible."	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 3 (respiratory tract irritation, narcotic effects)	Warning	H335 H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	No information was available for single exposure in humans. As for experimental animals, it was reported in a 4-hour single inhalation exposure test with rats, lacrimation, labored breathing, reduced activity, prostration, and ataxia were observed at doses of 55.0 mg/L or more, exceeding Category 2, and tremors were observed at doses of 82.6 mg/L or more (SIDS (2012), PATTY (6th, 2012)). Also it was reported that in another 4-hour single inhalation exposure test with rats, at doses of 57.0 mg/L or more, exceeding Category 2, findings indicating irritation to the mucous membranes such as rubbing of the eyes and nose, eye closure, sneezing, and lacrimation were observed within approximately 15 minutes after exposure, moreover, increased respiration, restlessness, uncoordinated movement, staggering gait, muscular weakness, cyanosis, sedation and lethargy were observed (SIDS (2012), SIDS Dossier (2012)). From the above, it was classified in Category 3 (respiratory tract irritation, narcotic effects).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 2 (blood system, liver)	Warning	H373	P260 P314 P501	As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats dosed by gavage, hyaline deposits in proximal tubules and basophilic renal tubules in the kidneys which were considered to be indicative of alpha 2u-globulin nephropathy was observed at or above 10 mg/kg/day (converted guidance value: 4.7 mg/kg/day), which is within the guidance value range for Category 1, an increase in total cholesterol, centrilobular hepatocellular hypertrophy, periportal fatty degeneration of hepatocytes in the liver, etc. were observed at or above 50 mg/kg/day (converted guidance value: 23.3 mg/kg/day), which is within the guidance value range for Category 2, and decreased body weight, lower values of erythrocyte, hemoglobin, and hematocrit, an increase in platelet count, prolonged prothrombin time and activated partial thromboplastin time, increased albumin and gamma-GT, hemosiderosis in the spleen were observed at or above 200 mg/kg/day (converted guidance value: 93.3 mg/kg/day) (SIDS (2012)). Also in a 13-week inhalation toxicity study with rats (6 hours/day, 5 days/week), chronic nephrosis which is thought to be alpha 2u-globulin nephropathy at or above 0.033 mg/L (converted guidance value: 0.024 mg/L), which is within the guidance value range for Category 1 (vapour), increases in the mean absolute and relative weights of the kidneys (males only), and an increase in alveolar macrophages were observed at or above 0.36 mg/L (converted guidance value: 0.26 mg/L), which is within the guidance value range for Category 2 (vapour) (SIDS (2012)). From the above, the changes in the kidney are considered to be findings specific to male rats, and the increase in alveolar macrophages is a physiological response to foreign matter, therefore, these were not used as basis for classification. Therefore, it was classified in Category 2 (haemal system, liver).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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