Item | Information |
---|---|
CAS RN | 75-68-3 |
Chemical Name | 1-Chloro-1,1-difluoroethane; HCFC-142b |
Substance ID | m-nite-75-68-3_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Category 1 |
Danger |
H220 | P210 P377 P381 P403 |
It was classified in Category 1 based on a lower flammable limit of 6.2 vol% and an upper flammable limit of 18 vol% (HSDB (Access on May 2020)). Besides, it is classified in Division 2.1 in UNRTDG (UN2517). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It was classified as "Not classified" because it was classified in Category 1 for flammable gases. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Low pressure liquefied gas |
Warning |
H280 | P410+P403 | It was classified as low-pressure liquefied gases based on a critical temperature of 136.85 deg C (HSDB (Access on May 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to gas substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (EHC 139 (1992)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). [Evidence Data] (1) LC50 for rats (4 hours): 128,000 ppm (SIAR (2004), EHC 139 (1992)) (2) LC50 for rats (4 hours): 2,050 mg/L (498,731 ppm) (Environmental Risk Assessment for Chemical Substances vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | [Rationale for the Classification] Gas (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] There were descriptions of (1), (2), but because it was not sufficient information for the category, the classification was not possible. Besides, there is a risk of frostbite, but because this substance was not applicable to refrigerated liquefied gas, H281 (may cause cryogenic burns or injury) was not applied. [Reference Data, etc.] (1) This substance is a gas at room temperature. Therefore, a skin irritation test is not applied to it (SIAR (2004)). (2) When liquid of this substance contacts with the skin or enters the eye, it causes frostbite (Environmental Risk Assessment for Chemical Substances vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | [Rationale for the Classification] There were descriptions of (1), (2), but because it was insufficient information for the category, the classification was not possible. Data that were the rationale in the previous classification were not considered as sufficient information for the category either. Therefore, the classification result was changed. Besides, there is a risk of frostbite, but because this substance was not applicable to refrigerated liquefied gas, H281 (may cause cryogenic burns or injury) was not applied. [Reference Data, etc.] (1) In an eye irritation test in which liquefied form of this substance was applied to the rabbit eye, no effects were seen in the cornea and iris, but slight conjunctival edema and discharge were observed. However, due to a boiling point of this substance of -9 deg C, it boiled out of the eye immediately after the application, and the results did not constitute evidence of effects in humans well (SIAR (2004), GESTIS (Access on May 2020)). (2) When liquid of this substance contacts with the skin or enters the eye, it causes frostbite (Environmental Risk Assessment for Chemical Substances vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) As for in vivo, it was reported to be negative in a chromosomal aberration test with rats bone marrow cells after 13-week inhalation exposure and negative in a heritable mutagenicity test (dominant lethal test) by 15-week inhalation exposure (SIAR (2004), MAK (DFG) vol.1 (1991), EHC 139 (1992)). (2) As for in vitro, it was reported to be negative and positive in bacterial reverse mutation tests (SIAR (2004), EHC 139 (1992)), and negative and positive in cell transformational tests with cultured mammalian cells (SIAR (2004)). (3) It was assessed in OECD SIAR that this substance did not pose a significant genotoxic hazard to humans (SIAR (2004)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There were no classification results by domestic and international organizations. There was no available report in humans. Negative results were reported in rats from (1), but because carcinogenicity test results in mice were not obtained, it was classified as "Classification not possible" due to lack of data. [Evidence Data] (1) In a combined chronic toxicity/carcinogenicity test by 104-week inhalation exposure of male and female rats to this substance, no treatment-related increase in tumor incidences was observed (SIAR (2004), EHC 139 (1992)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1), although the possibility of developmental effects was considered to be low, there was no information on sexual function and fertility, and classification was not possible due to lack of data. The evidence data was reviewed and the classification results were changed from the previous classification. [Evidence Data] (1) In a developmental toxicity study by inhalation exposure of female rats on days 6 to 15 of gestation, maternal toxicity was not observed, and reduced ossification (interparietal and supraoccipital bones of the skull, and the hyoid bone) was observed in fetuses, although no dose-related trends in incidence were apparent (IRIS (1995), Environmental Risk Assessment for Chemical Substances Vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). [Reference Data, etc.] (2) It was reported that, in a developmental toxicity study by inhalation exposure of female rats on days 4 to 13 or 6 to 15 of gestation, maternal toxicity was unknown and an increase in pre-implantation embryo loss was observed, but it was not dose-dependent (Environmental Risk Assessment for Chemical Substances Vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). The IRIS (1995) stated that the method and the report of this study were insufficient. (3) The result of a dominant lethal assay in which male rats were exposed by inhalation for 15-weeks was negative (SIAR (2004)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (narcotic effects, respiratory tract irritation) |
Warning |
H336 H335 |
P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] There was no report on single exposure to this substance in humans. Based on (1) and (2), it was classified in Category 3 (narcotic effects, respiratory tract irritation). A new information source was used and the classification results were changed from the previous classification. [Evidence Data] (1) In mice and rats exposed to high concentration of this substance, death or narcotic effects were observed (EHC 139 (1992)). (2) In a 6-hour acute inhalation exposure of rats, LC50 was above 1,640,000 mg/m3 (400,000 ppm) (converted 4-hour equivalent value: 489,898 ppm (exceeding Category 2)), and inflammation in the lung and central nervous system depression were observed at high concentrations (SIAR (2004)). [Reference Data, etc.] (3) It was reported that, in a test by a single administration of this substance by inhalation to dogs, cardiac sensitization was observed, and EC50 was 2,050,000 mg/m3 (498,731 ppm) (SIAR (2004)). (4) Chlorofluorocarbon compounds were known to sensitize the heart and increase sensitivity to adrenaline-induced arrhythmia (EURAR (2007)(CAS RN 75-45-6)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) to (3), no toxic effects were observed in test animals in an inhalation exposure test at concentrations far exceeding Category 2. Although information on repeated dose toxicity in the oral and dermal routes was not available, since this substance was a gas and the primary route of exposure was by inhalation, it was classified as "Not classified." [Evidence Data] (1) In a 90-day (6 hours/day, 5 days/week) test by inhalation exposure of rats in concentrations of 1,000 and 10,000 ppm (exceeding Category 2 in both cases), no exposure-related effects were observed (EHC 139 (1992), MAK (DFG) vol.1 (1991), IRIS (1995), SIAR (2004), Environmental Risk Assessment for Chemical Substances Vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). (2) In a 90-day (6 hour/day, 5 day/week) test by inhalation exposure of dogs in concentrations of 1,000 and 10,000 ppm (exceeding Category 2 in both cases), no exposure-related effects were observed (MAK (DFG) vol.1 (1990), SIAR (2004), Environmental Risk Assessment for Chemical Substances Vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). (3) In a 104-week (6 hour/day, 5 day/week) test by inhalation exposure of rats in concentrations of 20,000 ppm (exceeding Category 2), no exposure-related effects were observed (IRIS (1995), SIAR (2004), Environmental Risk Assessment for Chemical Substances Vol. 6, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2008)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Not classified |
- |
- | - | [Rationale for the Classification] Gas (GHS definition) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 96-hour LC50 = 36 mg/L for fish (Oncorhynchus mykiss) (EHC 139, 1992). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 3 |
- |
H412 | P273 P501 |
Reliable chronic toxicity data were not obtained. It was classified in Category 3 because it was not rapidly degradable (a 28-day degradation rate by BOD, OECD TG301D: 0% (Biodegradation and Bioconcentration Results of Existing Chemical Substances under the Chemical Substances Control Law, METI, 1991)), and it was classified in Category 3 in acute toxicity. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Category 1 |
Warning |
H420 | P502 | This substance is listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
|