Item | Information |
---|---|
CAS RN | 75-71-8 |
Chemical Name | Dichlorodifluoromethane |
Substance ID | m-nite-75-71-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified |
- |
- | - | It is classified in Division 2.2 (UN1028) in UNRTDG (not flammable and not toxic gas). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified |
- |
- | - | It is classified in Division 2.2 (UN1028) in UNRTDG and not given a Subsidiary Risk of 5.1 (oxidization). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Liquefied gas |
Warning |
H280 | P410+P403 | From a critical temperature (111.8 deg C (HSDB (Access on July 2013))) above + 65 deg C, it was classified as liquefied gas (low pressure liquefied gas). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to gas substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified (Not applicable) |
- |
- | - | Besides, it is reported that an LD50 value was > 1,000 mg/kg (EHC 113 (1990)), and no death was observed at 1,000 mg/kg (DFGOT vol. 5 (1993)) when the target substance was dissolved in peanut oil and orally administered to rats. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | It was classified as "Not classified" because an LC50 value of 760,000-800,000 mL/m3 for rats by inhalation exposure (converted 4-hour equivalent value: 268,701-282,842 ppm) (DFGOT vol. 5 (1993)) exceeded 12,500 ppm (gas 2,000 ppm (Category 4)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | From the information that it is slightly irritating (EHC 113 (1990)) and that there is no irritation (DFGOT vol. 5 (1993)), it is thought to be minimally or slightly irritating. Therefore, it was classified as "Not classified" (Category 3 in UN GHS classification) in JIS classification. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | There is the information that no significant eye irritation was observed in rabbits (ACGIH (7th, 2001), PATTY (6th, 2012)), while there is the information that it caused conjunctival irritation (DFGOT vol. 5 (1993)). Therefore, it was classified as "Classification not possible." Because the information in List 1 (DFGOT vol. 5 (1993)) was obtained in this investigation, the information in List 3, Chemical Substance Hazard Data (CERI), was deleted, and the classification was revised. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. As for rationale data for respiratory sensitization in the previous classification (DFGOT vol. 5 (1993)), the animal species used was dogs, and the test method was not according to the guidelines, therefore it is was insufficient to classify it as "Not classified" for respiratory sensitization. Because no other usable data were obtained, the classification was revised. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it is reported that it was negative in dominant lethal tests with rats by oral administration or mice by inhalation exposure (EHC 113 (1990), ACGIH (7th, 2001), JECFA (1975), IUCLID (2000)) and negative in a chromosomal aberration test with rats (IUCLID (2000)). Furthermore, as for in vitro, it was negative in a bacterial reverse mutation test and a gene mutation test with cultured mammalian cells (EHC 113 (1990), ACGIH (7th, 2001), DFGOT vol. 5 (1993), IUCLID (2000)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it is classified in A4 in ACGIH (7th, 2001), and it is described that no evidence of carcinogenicity was seen in animal tests (EHC 113 (1990), PATTY (6th, 2012)). The category was changed according to the revised GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | In a gavage administration three-generation test with rats, no general toxicity effects or toxicity effects on fertility were observed, and in developmental toxicity tests in rats by gavage administration or inhalation exposure and rabbits by inhalation exposure, no developmental toxicity, fetotoxicity, or teratogenicity was found (EHC 113 (1990), PATTY (6th, 2012)). From the above test results, it was classified as "Not classified." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Narcotic effects) |
Warning |
H336 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
It is described that in inhalation exposure experiments in human volunteers, findings such as slurred speech, decreased performance in psychomotor tests, amnesia, central nervous system depression, cardiac arrhythmia, a decrease in pulse, and a reduction in ventilatory lung capacity were observed (PATTY (6th, 2012), DFGOT vol. 5 (1993)), and central nervous system narcosis was found in tests in which rats and guinea pigs were given short-term inhalation exposure at high concentrations (500,000-900,000 ppm, 30 minutes) (EHC 113 (1990)). Therefore, it was classified in Category 3 (narcotic effects). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | As for reports on occupational exposure in humans, concerning death cases by inhalation exposure to a variety of halocarbon including this substance, there is a report that deaths were caused by cardiac arrhythmia while there is another report that there was no increase in deaths by occupational exposure, and there was no arrhythmia (PATTY (6th, 2012)). It is described in EHC 113 (1990) that deaths due to cardiac arrhythmia were observed for occupational exposure to halocarbon (CFC-113: trichlorotrifluoroethane), which is not this substance, but the similar case was not reported for exposure to this substance. Furthermore, nervous symptoms and low nerve conduction velocities were found in a refrigerator repair worker, and in a follow-up study, the symptoms were seen, but low nerve conduction velocities were not observed (EHC 113 (1990)). Therefore, effects on the nervous system are unclear together with the association with exposure to this substance. On the other hand, as for experimental animals, it is described that in a 90-day inhalation exposure test with guinea pigs, histological changes in the liver were found at the concentration (converted guidance value: 1,080 ppm) above the guidance value range for Category 2, but no toxicity effects were seen in other tests with rats or dogs in the inhalation or oral route (PATTY (6th, 2012)). From the above, the classification corresponds to "Not classified" in experimental animals, but it is unclear at this point whether occupational exposure affects the circulatory organ system and nervous system in humans, and there is no conclusive evidence on human health effects. Therefore, it was judged appropriate to classify it as "Classification not possible." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Not classified (Not applicable) |
- |
- | - | Gas (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Classification not possible |
- |
- | - | No data available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Category 1 |
Warning |
H420 | P502 | This substance is listed in the Annexes to the Montreal Protocol | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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