Item | Information |
---|---|
CAS RN | 75-99-0 |
Chemical Name | 2,2-Dichloropropionic acid; Dalapon |
Substance ID | m-nite-75-99-0_v2 |
Download of Excel format | Excel file |
Item | Information |
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Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." Besides, sodium salt was targeted in the previous classification, but the titled substance was used this time. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Classification not possible |
- |
- | - | No data available. Besides, there is information that it is combustible (GESTIS (Access on May 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Classification not possible |
- |
- | - | No data available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to liquid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | The substance is an organic compound containing chlorine and oxygen (but not fluorine) which are chemically bonded only to carbon or hydrogen. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. Besides, there is information that it attacks aluminium, copper, and their alloys (ICSC (2003)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1), (2). (3) was deleted from the rationale because it was not described in the source literature. [Evidence Data] (1) LD50 for rats: females: 6,936 mg/kg, males: 7,126 mg/kg (HSDB (Access on May 2020)) (2) LD50 for rats: 7,000 mg/kg (MAK (DFG) (2004)) [Reference Data, etc.] (3) LD50 for rats: 700-1,000 mg/kg (GESTIS (Access on May 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (ACGIH (7th, 2001), MAK (DFG) (2004), HSDB (Access on May 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Liquid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
[Rationale for the Classification] It was classified in Category 2 from (1), (2). The classification result was changed due to new data obtained. [Evidence Data] (1) This substance was irritating to the eye, skin, and respiratory tract (GESTIS (Access on May 2020)). (2) This substance was moderately irritating to the eye and skin (HSDB (Access on May 2020)). [Reference Data, etc.] (3) It was classified in Skin Irrit. 2 (H315) in EU-CLP classification (EU CLP classification (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] It was classified in Category 1 from (1). The classification result was changed due to new data obtained. [Evidence Data] (1) Direct contact with this substance could cause permanent eye damage (GESTIS (Access on May 2020)). [Reference Data, etc.] (2) This substance was irritating to the eye, skin, and respiratory tract (GESTIS (Access on May 2020)). (3) It was classified in Eye Dam. 1 (H318) in EU-CLP classification (EU CLP classification (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. Besides, the data used as the rationale in the previous classification could not be confirmed in available information sources. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for in vitro, it is reported that the sodium salt of this substance was negative in a bacterial reverse mutation test (ACGIH (7th, 2001)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] There is no available report targeted at humans. No carcinogenicity test result on this substance was obtained in experimental animals, but ACGIH classified this substance in A4 in (1) based on the test results for the sodium salt in (2) and because this substance was not genotoxic. Therefore, this substance was classified as "Not classified." [Evidence Data] (1) As for classification results by domestic and international organizations, ACGIH classified it in A4 (ACGIH (7th, 2001)). (2) In tests in which the sodium salt of this substance (CAS RN 127-20-8) was administered to dogs for 1 year and rats for 2 years, no tumor incidences were observed in either species (ACGIH (7th, 2001)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Not classified |
- |
- | - | [Rationale for the Classification] Based on (1) and (2), it was classified as "Not classified. Although the information source for the previous classification could not be used, a new information source and the information on the sodium salt of this substance were used. As a result, the classification results were changed from the previous classification. [Evidence Data] (1) In a developmental toxicity study with female rats dosed by gavage on days 6 to 15 of gestation, only a decrease in fetal body weight was observed, and no teratogenicity was observed even at doses exceeding the limit level (ACGIH (7th, 2001)). (2) In a three-generation test in which 150 mg/kg/day of sodium salt of this substance (CAS RN 127-20-8) was dosed by feeding, no reproductive effects were observed (ACGIH (7th, 2001)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1) and (2), it was classified in Category 3 (respiratory tract irritation). New information sources were used and the classification results were changed. [Evidence Data] (1) Acute exposures to vapors or aerosols of this substance (details were not provided) triggered weak to moderate irritations of the eyes, respiratory tract, and skin as well as the gastrointestinal tract in humans. Exposures to 2 to 7 ppm of this substance resulted in minimal irritations of the respiratory tract (GESTIS (Access on May 2020)). (2) The TLV-TWA (5 mg/m3) for this substance was set to minimize the potential of ocular and respiratory tract irritation (ACGIH (7th, 2001)). [Reference Data, etc.] (3) Accidental oral intake of this substance is expected to entail irritative effects or possibly corrosive effects and gastrointestinal disorders (vomiting, diarrhea) in humans (GESTIS (Access on May 2020)). (4) Common symptoms of poisoning are a feeling of lassitude, vomiting, diarrhea, slowing of pulse, loss of appetite, etc. (HSDB (Access on May 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] Based on (1) and (2) showing data from the studies using sodium salt of this substance, this substance was considered to be classified as "Not classified" in the oral route but there was no data available on the other administration routes. Therefore, classification was not possible due to lack of data. [Evidence Data] (1) In a 97-day study of rats dosed with sodium salt of this substance (CAS RN 127-20-8) by feeding, at 115 mg/kg/day, an increase in kidney weight was observed in female rats, but no abnormalities were observed in other examinations including histopathological examinations (ACGIH (7th, 2001)) (2) In a two-year study of rats dosed with sodium salt of this substance (CAS RN 127-20-8) by feeding, at 50 mg/kg/day, an increase in relative kidney weight was observed, but no histopathological changes were observed (ACGIH (7th, 2001), IRIS (1988)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 96-hour LC50 = 5,500 mg/L for fish (Alburnus alburnus) (ECOTOX, 2020). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. It was classified as "Not classified" because it is not rapidly degradable (BIOWIN), and it was classified as "Not classified" in acute toxicity. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
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