NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7580-67-8
Chemical Name	Lithium hydride
Substance ID	m-nite-7580-67-8_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Classification not possible	- -	-	-	It is written that it is flammable (ICSC(J) (2014)), but the classification is not possible due to no data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 200 deg C (ICSC(J) (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Category 1	Danger	H260	P302+P335+P334 P231+P232 P370+P378 P402+P404 P223 P280 P501	It is written that it reacts vigorously with water (ICSC(J) (2014)). Due to Division 4.3, PGI (UN1414) in UNRTDG, it was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Not classified	- -	-	-	It is written that it is a strong reducing agent and reacts vigorously with oxidants (ICSC(J) (2014)).	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Classification not possible due to lack of data. Additionally, although an LD50 value of 77.5 mg/kg (RTECS) for rats is reported, this information source is listed in List 3, and the original article is unknown. Therefore, it is not possible to classify only with this value.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Two LC50 values (4hours) of 960 mg/m3 (converted value: 0.96 mg/L) (male and female) (ACGIH (7th, 2015)) and 1,800 mg/m3 (converted value: 1.80 mg/L) (male and female) (ACGIH (7th, 2015)) for rats are reported. One of these two corresponds to Category 3, and the other corresponds to Category 4. This substance was classified in Category 3 by adopting the category with higher hazard. Besides, the data (DFGOT Vol.3 (1991)) used for the previous classification was not adopted as the evidence of the classification because it did not specify an LC50 value.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	It is reported that it is a severe irritant to the skin (HSDB (Access on June 2016)), and it may be corrosive (ACGIH (7th, 2015)) in humans. Therefore, this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	Because it is reported that it indicates severe eye irritation in humans (DFGOT (1992), HSDB (Access on June 2016)), this substance was classified in Category 1.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1A,	Danger	H360 H362	P308+P313 P201 P202 P260 P263 P264 P270 P280 P405 P501	There is no information on the reproductive effects of this substance itself. However, this substance is rapidly hydrolyzed to produce lithium hydroxide (CAS RN 1310-66-3 (anhydride: 1310-65-2)), a strong alkali, on contact with water vapor and the mucous membrane (ACGIH (7th, 2015)). Therefore, it is considered that information on lithium salts is available for classification. In humans, an association between lithium dosing in pregnant women and cardiovascular anomalies, such as Ebstein's anomaly, was first reported in 1974. Ebstein's anomaly had since then been thought to occur at a high rate (400 times higher than spontaneous rate), but Cohen et al., reported that based on a reanalysis, the occurrence of Ebstein's anomaly was 2/1,000 live births compared to the spontaneous rate of 1/20,000 live births (Cohen L.S. et al.: JAMA, 271, 146 (1994)). It was indicated that lithium is a "weak" teratogen in humans (Giles J.J and Bannigan J.G.: Curr. Pharm. Des., 12, 1531 (2006)). Thereafter, up to 2016, Cohen et al.'s finding of 2/1,000 cases (0.2%) was cited as the occurrence rate of Ebstein's anomaly due to lithium treatment in pregnant women; and it has been cautioned that special attention, such as observations of high-resolution ultrasound and fetal echo-cardiography, is necessary with regard to pregnant women with bipolar disorder receiving lithium treatment (Khan S.J. et al.: Curr. Psychiatry Rep., 18, 13 (2016)). Also, according to an observational study from Israel in 2014, it was reported that cardiovascular anomalies in neonates occurred more frequently in the lithium-dosed group at 2.4% (5/123 cases) compared with the control group at 0.6% (4/711cases); and the occurrence of cardiovascular anomalies in the combined multicenter data of Australia and Canada was 0.5% (4/842 cases) for the control group and 3.9% (6/152 cases) for the lithium-dosed group (Diav-Cirtrin, O. et al.: Am. J. Psychiatry, 171, 785 (2014)). From the above, it is thought that the cardiovascular anomalies, including Ebstein's anomaly, are clearly considered to be the effect of lithium administration. Furthermore, as for lithium dosing in the first trimester of pregnancy, it is also reported that other signs of neonatal toxicity such as neuropathy, respiratory disturbances, floppy infant, hyperbilirubinemia, disturbance of the heart's rhythm, hypothyroidism, and diabetes insipidus were observed (Khan S.J. et al.: Curr. Psychiatry Rep., 18, 13 (2016)). 　As for experimental animals, when lithium carbonate was administered orally to pregnant rats from day 6-15 of gestation at 100 mg/kg, fetal toxicity (reduction in number of implantation and of the live fetus, increased trend in the number of embryo resorptions) and teratogenicity (wavy ribs, shortening of bones such as the humerus and the femur, malformations in the skull and pelvis, separation in the skull) were recognized (Marathe M.R. and Thomas G.P.: Toxicol. Lett., 34, 115. (1986)). Also, when lithium carbonate was administered intraperitoneally to pregnant female mice at doses ranging from 330 to 340 mg/kg on the ninth gestation day, induction of malformations such as exencephaly, cranioschisis, rachischisis, kinking of the spinal cord, and dilation of the fourth brain ventricle etc. were observed (Jurand A.: Teratology, 38 (2), 101. (1988)). On the other hand, there are several reports in which no developmental effects were observed by lithium administration to pregnant animals, but it is thought that this was due to differences in doses and the animal lineage (Giles, J.J. and Bannigan, J.G.: Curr. Pharm. Des., 12, 1531 (2006)). 　From the above, as for humans, it was reported that cardiovascular anomalies and various developmental effects occur from lithium dosing during pregnancy; as for experimental animals as well, there are reports of teratogenicity. Therefore, this substance was classified in Category 1 for this hazard class. Furthermore, in an examination until 52 weeks after post partum, the lithium levels in the breast milk and the neonatal serum were about half and one fourth of the maternal serum levels, respectively (Khan S.J. et al.: Curr. Psychiatry Rep., 18, 13 (2016)). In Japan, lithium (lithium carbonate) is contraindicated for women anticipating pregnancy, but when administration is inevitable, breast-feeding must be discontinued (Ethical Pharmaceuticals 2017 (2016)). Therefore, "additional category for effects on or via lactation" was added to the classification.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs), Category 2 (nervous system)	Danger Warning	H370 H371	P308+P311 P260 P264 P270 P321 P405 P501	This substance is rapidly hydrolyzed to produce lithium hydroxide, a strong alkali, on contact with water vapor and the mucous membranes. It is described that lithium hydroxide causes intensely and immediately caustic damage in the nasal, oral, pharyngeal and respiratory mucosa, and can cause pulmonary edema (ACGIH (7th, 2015)). 　In addition, it is reported that in humans, nausea, muscle twitches, mental confusion, blurring of vision and coma are caused by accidental ingestion of this substance (HSDB (Access on June 2016)). Therefore, this substance was classified in Category 1 (respiratory organs), Category 2 (nervous system). 　Since HSDB is an information source listed in List 2, this substance was classified in Category 2 for the nervous system.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2016	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information