NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	76-03-9
Chemical Name	Trichloroacetic acid
Substance ID	m-nite-76-03-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (J) (1998), Hommel (1996))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Auto-ignition point is >110 degC (Gangolli (vol. 7, 2nd, 1999)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (J) (1998), Hommel (1996))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance contains oxygen and chlorine which are chemically bonded only to carbon or hydrogen.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available. Information is available that the substance corrodes iron, zinc and aluminum (HSDB (2007)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on a LD50 value of 3320 mg/kg for rats (ACGIH (2001)), the substance was classified into "Not classified" in JIS Classification (correspond to Category 5 in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >2000 mg/kg for rats (SIDS (access on April. 2009)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Although LC50 values were >4800 ppm (32.2 mg/L) for rats, rabbits, guinea pigs and cats (SIDS (access on April. 2009)), the details were not clear and the original literature can not be confirmed. Classification was not possible due to lack of data. (Since the test was considered to be conducted at higher than the saturated vapour pressure concentration, the LC50 values correspond to "Not classified").	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	There is a result of corrosive to the skin of rabbits (SIDS (access on April. 2009)). In another rabbit test, there are results of "slight irritation" after application of 0.21 mg and "severe irritation" after application of 3.5 mg (BUA 167 (1995)). Additionally, it has been reported that depending upon concentration and duration of contact, the substance can produce burns (ACGIH (2001)). Based on these information and a pH of < 1 (900 g/L, 20 degC) (IUCLID (2000)), the substance was classified into Category 1. As relevant information, the substance is classified into C; R35 in EU classification.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	There is a report that severe and extensive loss of epithelium and endothelium, infiltration and hemorrhage about the limbal vessels occurred in a rabbit test (ACGIH (2001)) and a report that severe injury of the eye was caused after application of a 30% solution to rabbit eyes which was not completely reversible within 21 days. The Modified Maximum Average Score (MMAS) was calculated to be 106 at 24, 48 and 72-hour, respectively, after application (ECETOC TR48 (1998)). Based on these information and a pH of <1 (900 g/L, 20 degC), the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	Although there is a report of not skin sensitizing in a guinea pig maximization test (IUCLID (2000), BUA 167 (1995)), the data is reported in a document in List 2 and the details are unknown. Classification was not possible due to lack of sufficient data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Based on positive results in a bone marrow micronucleus test and a chromosomal aberration test by intraperitoneal administration to mice (in vivo somatic cell mutagenicity test) (IARC vol. 63 (1995), IRIS (2003)) and in hepatic cell DNA damage tests by oral administration to mice and rats (in vivo somatic cell genotoxicity test) (IARC vol. 63 (1995), IRIS (2003)), the substance was classified into Category 2. As relevant information, from in vitro mutagenicity tests, there are negative Ames tests (ACGIH (2001), IARC vol. 63 (1995), IRIS (2003), NTP DB (access on 2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] As for carcinogenicity, there is no available report in humans. Based on the IARC's classification result (1) and test results of (2), (3), it was classified in Category 2. [Evidence Data] (1) As for classification results by domestic and international organizations, IARC classified it in Group 2B by stating that there is sufficient evidence in experimental animals (IARC 106 (2014)). Other than this, EPA classified it in S (IRIS (2011)), and ACGIH classified it in A3 (ACGIH (7th, 2014)) respectively. (2) In four tests in which male mice were dosed by drinking water for 61 weeks, 52 weeks (two tests), 104 weeks respectively, increases in hepatocellular adenoma and carcinoma were observed (IARC 106 (2014)). (3) In two tests in which female mice were dosed by drinking water for up to 576 days and 52 weeks respectively, increases in hepatocellular adenoma and carcinoma were observed (IARC 106 (2014)). [Reference Data, etc.] (4) In a test in which rats were dosed by drinking water for 104 weeks, clear evidence for carcinogenicity was not shown (IARC 106 (2014)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a developmental toxicity test by oral administration of the substance to rats during organogenesis period, dose-dependent increases in percent of resorbed implants per litter and reductions in weight and length of live fetuses were observed at dose levels in which parental general toxicity was noted (weight gain was reduced). Additionally, cardiovascular and skeletal malformations were found at higher dose levels (ACGIH (2001)). Based on the report, the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	Based on a report that animals poisoned by oral exposure quickly passed into a state of narcosis or seminarcosis. Within 36-hour, the esposed animals either recovered completely or died (ACGIH (2001)). Based on this information the substance was classified into Category 3 (narcotic effects). Although there is a report that breathing the substance can irritate the lungs causing coughing and/or shortness of breath; higher exposures can cause a build-up of pulmonary edema (HSFS (2004), SITTIG (5th, 2008), ICSC (J) (1998)), these findings were not used as the basis of classification since the information is found in documents in List 3 and lack detailed data.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In both male rats administered up to 350 - 785 mg/kg/day of the substance in their drinking water for 90 days (ACGIH (2001), IARC vol. 63 (1995)) and male mice administered up to 500 mg/kg/day in their drinking water for 10 weeks (Initial Environmental Risk Assessment of Chemicals (Ministry of the Environment) (2006)), no significant toxic findings were noted. Since these tests were conducted using males only and the adequacy of the examination parameters is questionable, classification was not possible.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Classified into Not classified from its 96h-LC50 = 2000 mg/L for fish (Fathead minnow) (SIDS, 2003) and 48h-EC50 = 2000 mg/L for Crustacea (Daphnia magna) (SIDS, 2003).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No reliable chronic toxicity data available. Classified into Not classified since its 96h-LC50 = 2000 mg/L for fish (Fathead minnow) (SIDS, 2000), 24h-EC50 = 2000 mg/L for Crustacea (Daphnia magna) and it is not non-water soluble (Water solubility = 54600 mg/L, PHYSPROP Database, 2009).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	No data available.	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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