NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	76-13-1
Chemical Name	1,1,2-Trichloro-1,2,2-trifluoroethane; CFC-113
Substance ID	m-nite-76-13-1_v2
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	It is not combustible (HSDB (Access on August 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is not combustible (HSDB (Access on August 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (HSDB (Access on August 2014)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing fluorine and chlorine (but not oxygen) which are chemically bonded only to carbon or hydrogen.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to low-temperature-boiling liquids are not available.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on reports of an LD50 value of 43,000 mg/kg for rats (PATTY (6th, 2012), Environmental Risk Assessment for Chemical Substances Vol.4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), ACGIH (7th, 2001), DFGOT vol. 3 (1999), EHC 113 (1990), OEL Documentations (Japan Society For Occupational Health (JSOH), 1987)), it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a report of a lethal dose of 11,000 mg/kg for rabbits (ACGIH (7th, 2001)), and a report of an LD50 value of > 11,000 mg/kg for rabbits (RTECS (original reference: Wolf Ledges Pkwy. and Akron (1968))), it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified	- -	-	-	Based on reports of LC50 values of 52,500 ppm (EHC 113 (1990)) and 52,000-68,000 ppm (ACGIH (7th, 2001), OEL Documentations (Japan Society For Occupational Health (JSOH), 1987)) for rats, it was classified as "Not classified." Besides, the LC50 values were lower than 90% of the saturated vapor concentration (355,380 ppm), the reference value in units of ppm was applied as a vapour without a mist.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	There were 3 reports of tests in which this substance was applied to the skin of rabbits, and their results were "no irritation" (ACGIH (7th, 2001)), "slight irritation" (IUCLID (2000)) and "local irritation" (EHC 113 (1990)), respectively. From the above results, it was classified as "Not classified" (Category 3 in UN GHS classification). The category was changed according to the revised GHS classification guidance for the Japanese government.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	There is a report that after application of 0.1 mL of this substance to the eyes of rabbits, mild conjunctivitis and a minimal corneal reaction were observed but these disappeared within 48 hours (DFGOT vol. 3 (1992)). There are reports that in other tests with rabbits, slight irritation was observed (IUCLID (2000)) or no irritation was observed (ACGIH (7th, 2001)). From the above results, since it seemed to cause slight irritation, it was classified in Category 2B. Information was added, and the category was changed.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, although there is a report that no sensitization was observed in a sensitization test (maximization method) with guinea pigs (IUCLID (2000)), it was judged to be inadequate data for use in classification since details of the test conditions and results were unknown.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The substance was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse dominant lethal test (ACGIH (7th, 2001), EHC 113 (1990), PATTY (6th, 2012), DFGOT vol. 3 (1992), IUCLID (2000)). As for in vitro, it was negative in bacterial reverse mutation tests, and a chromosome aberration test and a sister chromatid exchange test with cultured mammalian cells (ACGIH (7th, 2001), DFGOT vol. 3 (1992), EHC 113 (1990), PATTY (6th, 2012), IUCLID (2000)).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Since it was classified in A4 by ACGIH (ACGIH (7th, 2001)), it was classified as "Classification not possible."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	In a one-generation reproductive toxicity test with rats by the inhalation route, there were no descriptions of parental toxicities, but no effects on fertility were observed even at 12,500 ppm. There is a report that in a teratogenicity test with rats by the inhalation route, neither embryotoxicity, fetotoxicity, nor teratogenicity was observed at the dose (25,000 ppm) where toxicities (decreased body weight gain, decreased food consumption) were observed in maternal animals (PATTY (6th, 2012), ACGIH (7th, 2001), EHC 113 (1990)). Therefore, it was classified as "Not classified."	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (cardiovascular system), Category 3 (respiratory tract irritation, narcotic effects)	Danger Warning	H370 H335 H336	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	This substance was irritating to the respiratory tract (ACGIH (7th, 2001)). In humans, short-term exposure might affect the cardiovascular system and central nervous system, resulting in cardiac disorders and central nervous system depression, and causing lowering of consciousness. In addition, as acute symptoms, there were reports of arrhythmia, confusion, lethargy, shortness of breath and loss of consciousness by inhalation exposure, and of lethargy, loss of ability to concentrate and cardiac arrhythmia although route was unknown, and of cardiac insufficiency, asphyxiation and death by inhalation exposure at very high concentrations. Moreover, there was a report of narcotic effects (Environmental Risk Assessment for Chemical Substances Vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), ACGIH (7th, 2001)). As for experimental animals, there were reports of transient lethargy by an inhalation exposure with rats at 12,000 ppm, of tachycardia, hypotension and myocardial depression by inhalation exposure with rats, dogs and monkeys at or above 25,000 ppm, coma, asphyxiation and arrhythmia at very high concentrations (concentration not described), and of vomiting, lethargy, nervousness and tremors in dogs (concentration not described) (ACGIH (7th, 2001), DFGOT vol. 3 (1992)). From the above, this substance was considered to cause effects on the cardiovascular system, respiratory tract irritation, and narcotic effects in humans, therefore, it was classified in Category 1 (cardiovascular system), Category 3 (respiratory tract irritation, narcotic effects). Besides, since the description of the effects on the respiratory organs in the previous classification could not be confirmed, it was not adopted.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, liver)	Danger	H372	P260 P264 P270 P314 P501	In humans, there is a description that effects on the central nervous system (somnolence, decreased orientation, diminished ability to concentrate on mental tasks) were observed by repeated inhalation exposure as occupational exposure (Environmental Risk Assessment for Chemical Substances Vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), DFGOT vol. 3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1987)), and liver disorders (elevated blood AST and ALT activities, fatty infiltration in the liver) were observed (OEL Documentations (Japan Society For Occupational Health (JSOH), 1987)). On the other hand, there is a report that even by repeated exposure at high concentrations, no effects were observed in a hematological test and on liver functions, and diminished ability to concentrate in mental work tests did not also occur (Environmental Risk Assessment for Chemical Substances Vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), ACGIH (7th, 2001), DFGOT vol. 3 (1992), OEL Documentations (Japan Society For Occupational Health (JSOH), 1987)). As for experimental animals, by inhalation with rats to this substance (estimated as the vapour) at 7,650 mg/m3 for 2 weeks, proliferation and vacuolization of the smooth endoplasmic reticulum in hepatocytes, and fat accumulation in the liver were observed at concentrations slightly above the range of Category 2 (converted guidance value: 1.18 mg/L/6 hours) (Environmental Risk Assessment for Chemical Substances Vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), ACGIH (7th, 2001), DFGOT vol. 3 (1992)). On the other hand, in studies in which rats were exposed by inhalation at very high concentrations (38,300-76,600 mg/m3 (converted guidance value: 14.9-76.6 mg/L/6 hours)) for 30 days or 2 years, although increased relative liver weight and a pale liver were observed at doses where decreased body weight gain was observed, no histological changes were observed (Environmental Risk Assessment for Chemical Substances Vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), ACGIH (7th, 2001), DFGOT vol. 3 (1992)). In addition, by exposure at high concentrations (84,300-93,000 mg/m3, 2 hours/day) with rats and rabbits for 2 years, no abnormalities were observed other than slight sleepiness and dizziness (Environmental Risk Assessment for Chemical Substances Vol. 4, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2005), ACGIH (7th, 2001), DFGOT vol. 3 (1992)). From the above, in humans, there are findings that raised concerns over the effects on the central nervous system and liver, and also in experimental animals, findings supporting these effects by exposure at high concentrations were obtained, therefore, it was classified in Category 1 (central nervous system, liver).	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))
12	Hazardous to the ozone layer	Category 1	Warning	H420	P502	In preparation. Check the Japanese version.	FY2022	GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

To GHS Information