NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	763-69-9
Chemical Name	Ethyl 3-ethoxypropanoate
Substance ID	m-nite-763-69-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Category 3	Warning	H226	P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501	A flash point of 59 degrees C [closed cup] (IUCLID (2000)), which is >= 23 degrees C and <= 60 degrees C, corresponds to Category 3.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified	- -	-	-	It is conceivable that it does not ignite at normal temperatures from an ignition point of 377 degrees C (Ullmanns (E) (2003)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No established test method suitable for liquid substances.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Not containing metals or semimetals (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	An organic compound that contains oxygen which is not chemically bonded to elements other than carbon.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	An organic compound that does not contain -O-O- structure.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	From an LD50 value of 5000 mg/kg for rats (PATTY (5th, 2001)), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	From an LD50 value of > 9500 mg/kg for rabbits (HPVIS (2010), corresponding to List 2), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Liquids" according to GHS definition.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	The classification is not possible because the category could not be determined from no mortality in rats by inhalation of the saturated vapour pressure concentration (11.80 mg/L) for 8 hours (LC50 value > 11.80 mg/L/8hr = 16.68 mg/L/4hr) (PATTY (5th, 2001)) and an LC50 value of > 998 ppmV/6hr = 1222 ppm/4hr for rats (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" in JIS classification (Category 3 in UN GHS classification) from slightly irritating in 24-hour occlusive application test in guinea pigs (IUCLID (2000)) and a minor enhancement in irritation reactions after repeated application (9 times in 10 days) (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	Because slight irritation was observed in all in the test using 3 rabbits, it was classified in Category 2B. Besides, there is information that no fluorescein staining was observed in cornea or accessory organs in this test (IUCLID (2000)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	Lack of data. Besides, a skin sensitization test using guinea pigs (Freund's complete adjuvant test) reported not sensitizing (IUCLID (2000)). But it was classified as "Classification not possible,"because the data was from List 2 and the test method was not approved by OECD.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to no in vivo test data. Besides, a negative in an Ames test as an in vitro mutagenicity test (IUCLID (2000)) and a negative in a chromosomal aberration test using CHO cells (HPVIS (2010)) are reported.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	In an inhalation administration test during an organogenetic period in rats and rabbits (OECD TG 414; GLP), it was reported that rats showed an increase in rudimentary thoracolumbar ribs of 14th in addition to slight increased incidence in minor internal soft tissue alterations and skeletal variations at a high dose at which decreases in food consumption and weight gains were observed as general toxicities in dams, but teratogenicity and evidence of fetal toxicity were not found in both animal species. (HPVIS (2010)) However, because effects on sexual function and fertility in parent animals are unknown, it was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 3 (Narcotic effects)	Warning	H336	P304+P340 P403+P233 P261 P271 P312 P405 P501	From symptoms of weakness and ataxia after oral administration of 5000 mg/kg in rats (IUCLID (2000)) and symptoms of lethargy and decreased auricular and orientation reflexes by inhalation exposure of 1000 ppm to rats (IUCLID (2000)), it was classified in Category 3 (narcotic effects). Besides, exposure-related changes were not found in autopsy finding in all routes.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In a 90-day vapour inhalation exposure test in rats, it was reported that decreased weight gains, lacrimation, and lethargy and changes in blood biochemical test results but no exposure-related pathological changes were found, and NOAEL was 1.49 mg/L/day (250 ppm) above the upper limit (1 mg/L/day) in a range of guidance values (HPVIS (2010)). Therefore, it corresponds to "Not classified" in an inhalation route. And in a 28-day oral administration test in rats, an increase in serum enzymes (AST and SDH) and creatinine concentrations at a dose of 1000 mg/kg/day as the only effect (HPVIS (2010)) but no related histopathological findings were found. Accordingly, no serious toxic signs at 1000 mg/kg/day (converted to a 90-day equivalent value: 311 mg/kg/day) above the upper limit of a range of guidance values (100 mg/kg/day) as a result corresponds to "Not classified" in an oral route. However, it was classified as "Classification not possible" in specific target organ toxicity (repeated exposures) because effects in the dermal administration were unknown due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Because acute toxicity for algae, crustacea, and fish at 100 mg/L (nominal concentration) was not reported (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006), it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 86mg/L for algae (Pseudokirchneriella subcapitata) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006) despite lack of rapid degradability data. If acute toxicity data are used for a trophic level for which chronic toxicity data are lacking, then it is classified as "Not classified" due to non-poorly water soluble property (water solubility＝55500 mg/L, PHYSPROP Database 2012) and no report on acute toxicity for crustacea and fish at 100 mg/L (nominal concentration) (Results of Eco-toxicity tests of chemicals conducted by Ministry of the Environment in Japan, 2006). From the above results, it was classified as "Not classified."	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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