Item | Information |
---|---|
CAS RN | 7631-99-4 |
Chemical Name | Sodium nitrate |
Substance ID | m-nite-7631-99-4_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | The substance does not fall under Explosives since it is classified into Division 5.1 in UNRTDG (UN1498) though it contains chemical groups (-NO3) associated with explosive properties. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Flammable solids | Not classified |
- |
- | - | Not combustible (ICSC (J) (2001)) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | The substance is classified as Oxidizing solid. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible (ICSC (J) (2001)) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (ICSC (J) (2001)) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Although the substance contains a metal (Na) in the molecule, the water solubility data as "complete" (921 g/L (25 degC)) (ICSC (J) (2001)) is obtained and it is considered that the substance does not react vigorously with water. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
14 | Oxidizing solids | Category 3 |
Warning |
H272 | P370+P378 P210 P220 P280 P501 |
The substance is classified into Division 5.1, PG III (UN1498) in UNRTDG. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | The substance is not an organic compound. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on the rat LD50 value of 3700 mg/kg (EPA RED (1991)), the substance was classified as "Not classified" in the JIS classification (corresponding to Category 5 in the UN-GHS classification). This is the amendment in accordance with the GHS classification guidance for the Japanese government. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Although the rabbit LD50 value of < 2000 mg/kg was reported (EPA RED (1991)), the adequate category can not be derived from the data. Therefore, the substance was classified as "Classification not possible". | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | The substance was classified as "Not classified" (corresponding to Category 3 in the UN-GHS classification) based on the documented case of "mild or light irritation" (EPA RED (1991)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
The substance was classified as Category 2B based on the documented case that the substance caused corneal opacity and it was reversible within 7 days (EPA RED (1991)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
4 | Skin sensitization | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
5 | Germ cell mutagenicity | Category 2 |
Warning |
H341 | P308+P313 P201 P202 P280 P405 P501 |
The substance was classified as Category 2 based on the positive results in the in vivo micronucleus test using bone marrow of mice (IARC Vol.94 (2010), ECETOC TR27 (1988)). Positive results in the chromosome aberration test using rats and unclear ambiguous results in the chromosome aberration test using mice have been reported (ECETOC TR27 (1988), confirmed the original paper: Mutat. Res. 155, 121-125 (1985)). As for in vitro studies, negative and positive results in the Ames test and positive results in the chromosome aberration test using cultured cells were reported (IUCLID (2000)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | The classification was not possible due to no data available. As relevant information, the IARC (IARC Vol.94 (2010)) described that the evidence of carcinogenicity in humans for nitrates in drinking water was uncertain. And also, it was evaluated the carcinogenicity as "Group 2A" under the conditions that nitrates or nitrites could be nitrosated in vivo after oral ingestion. The comprehensive evaluation of the IARC described additionally as follows: There is an active endogenous nitrogen cycle in humans that involves nitrates and nitrites, which are interconvertible in vivo. Nitrosating agents that arise from nitrites under acidic gastric conditions react readily with compounds which are easily nitrosated, especially secondary amines and amides, to generate N-nitroso compounds. These nitrosating conditions are enhanced following ingestion of additional nitrates, nitrites or nitroso compounds. Some of the N-nitroso compounds have the possibility to form known carcinogens in humans under these conditions. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | It was reported that the pregnancy rate was reduced but no effect on reproductive organs was seen in the study in guinea pigs administered via drinking water (IUCLID (2000)). However, the details were unclear, therefore, the classification was not possible due to lack of data. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
It was reported that 15 soldiers who ingested sodium nitrate by mistake instead of table salts became methemoglobinemia, and that 13 ingested about 15 g died, while two ingested 5 g survived (ECETOC TR 27 (1988)). Based on the information, the substance was classified into Category 1 (blood). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood) |
Danger |
H372 | P260 P264 P270 P314 P501 |
With regard to chronic toxicity of general water-soluble nitrates, there were numerous reports of increased methemoglobin concentrations observed in the infants who ingested meal or water containing nitrates, and case reports of methemoglobinemia observed in the patients administered sodium nitrate or ammonium nitrate as a diuretic agent or in the patients treated with ammonium nitrate as an urolithiasis-preventive agent were presented (ECETOC TR27 (1988)). Based on the information, the substance was classified as Category 1 (blood). Besides, the effects on the heart, etc. were reported as ones of nitrates, but these were considered to be secondary effect by methemoglobinemia-induced hypoxia (EHC 5 (1978)). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | No data available. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | Classified as "Not classified" from its 96h-LC50 = 1685 mg/L for fish (Oncorhynchus mykiss) (SIDS, 2008). | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Classified as "Not classified" since it is not non-water soluble (water solubility = 730000 mg/L (PHYSPROP Database, 2009)) and its acute toxicity is low. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in Annexes to the Montreal Protocol. | FY2010 | GHS Classification Guidance by the Japanese Government (July, 2010) |
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