NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7647-01-0
Chemical Name	Hydrogen chloride
Substance ID	m-nite-7647-01-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified	- -	-	-	Not combustible gas (Hommel (1996))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified	- -	-	-	The substance is classified into Division 2.3 in UNRTDG (UN1050), Subsidiary risk 8, but not into Division 5.1 (Oxidizing substances) in UNRTDG.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	High pressure liquefied gas	Warning	H280	P410+P403	The substance is classified into Division 2.3 in UNRTDG (UN1050). Critical temperature is 51 degC (Hommel (1996)) between -50 degC and 65 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gaseous substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Based on LD50 values of 238 - 277 mg/kg and 700 mg/kg for rats (SIDS (2009)), the lower value was adopted and the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >5010 mg/kg for rabbits (SIDS (2009)), the substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Category 3	Danger	H331	P304+P340 P403+P233 P261 P271 P311 P321 P405 P501	Based on LC50 values of 4.2, 4.7 and 283 mg/L (4-hour equivalence: 1411, 1579 and 95,083 ppm, respectively) for rats (SIDS (2009)), the lowest value was adopted and the substance was classified into Category 3.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on a LC50 value (aerosol) of 1.68 mg/L/1h (4-hour equivalence: 0.42 mg/L) for rats (SIDS (2009)), the substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In a rabbit skin irritation test, application for 1 - 4-hour caused corrosion at higher concentrations (SIDS (2009)). Skin irritation and ulceration with fur discoloration occurred in mice and rats dermally exposed for 5 - 30 minutes (SIDS (2009)). In human experiments, there are reports that contact caused slight to strong irritation, or ulceration and severe burns to the skin (SIDS (2009)). Based on these data, the substance was considered to have corrosive properties, and was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	The substance was classified as a skin corrosive substance. In eye damage and irritation tests, solutions of the substance, hydrochloric acid, was used as a test substance. In animal tests including rabbit tests, high irritation, damage and corrosion to eyes have been reported (SIDS (2002)). For humans, the concentrated solution can cause permanent damage and loss of sight (SIDS (2002)). Based on these data, the substance was classified into Category 1. As relevant information, in EU classification, the substance is classified into C; R34.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Since the substance is on the sensitizing chemical substance list by Japanese Society of Occupational and Environmental allergy, the substance was classified into Category 1. There is a report that after exposure to a cleaning product that contained hydrogen chloride, the subject developed bronchospasm and still had marked asthma symptoms 1 year after exposure that were triggered by exercise and inhalation of trivial concentrations of irritants (ACGIH (2003)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Not classified	- -	-	-	A guinea pig maximization test and a mouse ear swelling test demonstrated negative results (SIDS (2009)) for the substance. In a human test using fifty volunteers, none gave a positive reaction in a challenge application, 10 – 14 days after the final induction application (SIDS (2009)). The substance was classified as "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data from in vivo mutagenicity tests. From in vitro mutagenicity tests, there is a report of a negative Ames test and a positive result (which is considered to be an artifact due to the low pH) chromosome aberration test (SIDS (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Not classified	- -	-	-	Based on the classifications of "Group 3" in IARC (1992) and "A4" in ACGIH (2003), the substance was classified as "Not classified". As relevant information, no evidence of carcinogenicity was observed in rat and mouse carcinogenicity tests (SIDS (2009)). Epidemiologic tests did not suggest an association between exposure to hydrogen chloride and cancer development (IARC 54 (1992), PATTY (5th, 2001)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	In rat and mice tests by exposure during gestation period, there were no adverse effects on fetal development, however, classification was not possible since there are no data for effects on sexual function and fertility by exposure before mating or gestation.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	In humans, inhalation exposure caused symptoms such as dyspnea, laryngitis, bronchitis, bronchoconstriction, pneumonia and edema. Inflammation and necrosis of the upper respiratory tract and pulmonary edema have also been reported (DFGOT vol. 6 (1994), PATTY (5th, 2001), IARC 54 (1992), ACGIH (2003)). In animal tests, toxic effects with morphological change of the lung and bronchus such as bronchitis with mucosal necrosis, pulmonary edema, hemorrhage, and thrombus were observed at dose levels within the guidance value range for Category 1 (ACGIH (2003), SIDS (2009)). Based on the information for humans and animals, the substance was classified into Category 1 (respiratory system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (teeth, respiratory system)	Danger	H372	P260 P264 P270 P314 P501	There are 2 or more reports for humans in which repeated exposure caused tooth damage by erosion (SIDS (2002), EHC 21 (1982), DFGOT vol. 6 (1994), PATTY (5th, 2001)). Additionally, an increase in the frequency of chronic bronchitis was reported (DFGOT vol. 6 (1994)). Based on the information, the substance was classified into Category 1 (tooth, respiratory system).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	Classified into Category 1 from its 48h-EC50 = 0.492 mg/L for Crustacea (Daphnia magna) (SIDS, 2005), etc.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Classified into Not classified since the toxicity is mitigated in environmental water by buffer action though it is considered to be a factor of toxicity that water solution becomes strongly acidic.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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