Item | Information |
---|---|
CAS RN | 7697-37-2 |
Chemical Name | Nitric acid |
Substance ID | m-nite-7697-37-2_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (N-O) present in the molecule. However, because it is classified in Class 8, Subsidiary Risk 5.1, PG I (UN2031), it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There is a chemical group associated with explosive properties (N-O) present in the molecule, but it was classified as oxidizing liquids. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Category 3 |
Warning |
H272 | P370+P378 P210 P220 P280 P501 |
As an example of test results for Division 5.1, PG III was described for nitric acid (65%) in the UNRTDG Manual of Tests and Criteria 5th revised edition (2009), therefore, it was classified in Category 3. Besides, it is classified in Class 8, Subsidiary Risk 5.1, PG I (UN2031) in UNRTDG. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Category 1 |
Warning |
H290 | P234 P390 P406 |
There are no test data, but because it is corrosive to metals (ICSC (2006)), it was judged to meet the criteria of corrosivity. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 1 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
There are reports of an LC50 value (4 hours) of 49 ppm for rats (OEL Documentations (Japan Society For Occupational Health (JSOH),1982)) and an LC50 value (30 minutes) of 334 ppm for rats (converted 4-hour equivalent value: 118 ppm) (ACGIH (7th, 2001), HSDB (Access on September 2014)). According to the GHS Classification Guidance for the Japanese Government, it was classified in Category 1 based on the 4-hour value. New information sources (ACGIH (7 the, 2001), HSDB (Access on September 2014), OEL Documentations (Japan Society For Occupational Health (JSOH), 1982)) were added, and the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there are data on fuming nitric acid, the main components were not nitric acid but nitrogen dioxide or dinitrogen tetraoxide, therefore, it was not adopted for the classification and it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There are reports that a liquid or a vapour of this substance showed severe damage to the skin (ACGIH (7th, 2001)), and that even short-exposure caused damage to the skin (DFGOT vol. 3 (1992)). In addition, there is a report that after application of an 8% solution of this substance to rabbits, necrosis was observed (DFGOT vol. 3 (1992)). From the above results, it was classified in Category 1. Since there were no specific data for sub-categorization, the category was changed. Besides, this substance was classified as "C; R35" in the EU DSD classification, as "Skin Corr. 1A H314" in the EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There are descriptions that this substance caused corneal injury and permanent visual impairment (DFGOT vol. 3 (1992)), and that it produced severe chemical burns to the eyes in humans, which resulted in eyeball shrinkage, symblepharon, and permanent corneal opacification, leading to blindness (ACGIH (7th, 2001)). Moreover, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There are no in vivo data. As for in vitro, it was negative in bacterial reverse mutation tests (SIDS (2010), DFGOT vol. 3 (1992), HSDB (Access on September 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report that in a teratogenicity test with rats by the oral route (drinking water), only slight ossification disorder (hyoid bone, parietal bone/occipital bone, wavy rib) was observed, and neither teratogenicity nor fetal toxicity occurred (IUCLID (2000)). However, because the descriptions of the test conditions and test results were insufficient, it was not used for classification. In addition, since there was no sufficient information on fertility, it was classified as "Classification not possible." |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
This substance was irritating to the respiratory tract (OEL Documentations (Japan Society For Occupational Health (JSOH), 1982), SIDS (2010), ACGIH (7th, 2001), DFGOT vol. 3 (1992)). In humans, there are reports of coughing, headache, nausea, chest pain, dyspnea, bronchoconstriction, respiratory disorder and pulmonary edema by inhalation exposure, and corrosion and necrosis of the mouth, esophagus and stomach, and pneumonitis by oral exposure (SIDS (2010), ACGIH (7th, 2001), DFGOT vol. 3 (1992)). As for experimental animals, there is a report of widespread inflammation of the respiratory tract, rhinitis, tracheitis and pneumonitis by inhalation exposure of rats at 8 ppm (0.02 mg/L) (SIDS (2010)), and there is a report of pulmonary edema at 49 ppm (0.12 mg/L) (OEL Documentations (Japan Society For Occupational Health (JSOH), 1982)). These symptoms were observed at doses within the range equivalent to Category 1. From the above, since this substance affected the respiratory organs, it was classified in Category 1 (respiratory organs). This substance was considered to have local effects due to its corrosivity, therefore, the oral cavity, esophagus and stomach in humans were not included as target organs. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs, teeth) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There are descriptions that dental erosion was exhibited in 3 of 32 workers who were occupationally exposed to inhalation to nitric acid (no onset in 293 workers in the control group) (SIDS (2010), ACGIH (7th, 2001), DFGOT vol. 3 (1992)), and that repeated exposure to the vapour and mists of nitric acid may result in a chronic bronchitis, and more severe exposure resulted in chemical pneumonitis, and further erosion of the teeth, particularly the canines and incisors (ACGIH (7th, 2001), DFGOT vol. 3 (1992)). As for experimental animals, there was no test result from repeated exposure to this substance. From the above, based on the findings on occupational exposure in humans, it was classified in Category 1 (respiratory organs, teeth). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | There is a description that in a case of delayed death after ingestion of a large amount of this substance, chemical pneumonitis due to aspiration was found at autopsy (ACGIH (7th, 2001)). However, it was a finding in only one case, and considering the description of effects due to secondary "aspiration" by the large ingestion (ACGIH (7th, 2001)), it was hard to say that the finding corresponded to "reliable and good quality human evidence," the criteria for Category 1. Therefore, it was classified as "Classification not possible" due to lack of data. Besides, although in the previous classification, it was classified in Category 1 based on the findings in ACGIH, the judgment was changed in this review. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
It was classified in Category 3 from 96-hour LC50 = 72 mg/L for fish (Gambusia affinis) (SIDS, 2010). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | Reliable chronic toxicity data were not obtained. Nitric acid exists widely as natural substances, and from results of acute toxicity test on the salts, it is known that decreased pH causes acute toxicity. It is known to cause adverse effects when concentrations of nitrate ions are high, but it is estimated that toxicity does not occur generally at a concentration of 1 mg/L for classification in chronic toxicity. Therefore, it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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