Latest GHS Classification Results by the Japanese Government (edited by NITE)
GENERAL INFORMATION
REFERENCE INFORMATION
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
GENERAL INFORMATION
| Item | Information |
|---|---|
| CAS RN | 77-73-6 |
| Chemical Name | Dicyclopentadiene |
| Substance ID | m-nite-77-73-6_v1 |
| Download of Excel format | Excel file |
REFERENCE INFORMATION
| Item | Information |
|---|---|
| Guidance used for the classification (External link) | To Guidance List |
| UN GHS document (External link) | To UN GHS document |
| FAQ（GHS classification results by the Japanese Government） | To FAQ |
| List of Information Sources (Excel file) | List of Information Sources |
| List of Definitions/Abbreviations | Definitions/Abbreviations |
| Sample Label by MHLW (External link) | MHLW Website (in Japanese Only) |
| Sample SDS by MHLW (External link) | MHLW Website (in Japanese Only) |
| OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). Besides, technical products (purity not less than 95%) are liquid due to a melting point of 11-13 deg C (16716 chemical products (The Chemical Daily Co., Ltd., 2016)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 6 | Flammable liquids | Category 3 |
 Warning |
H226 | P303+P361+P353 P370+P378 P403+P235 P210 P233 P240 P241 P242 P243 P280 P501 |
It is a solid (GHS definition), but because melting point is around 33 deg C, and a flash point is 39 deg C (closed cup) (GESTIS (Access on June 2017)), it was classified in Category 3. Besides, it is classified in Class 3, PGIII in UNRTDG (UN 2048). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 7 | Flammable solids | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 10 | Pyrophoric solids | Not classified |
- |
- | - | It is estimated that it does not ignite at normal temperatures from an autoignition temperature of 500 deg C (GESTIS (Access on June 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 11 | Self-heating substances and mixtures | Classification not possible |
- |
- | - | Test methods applicable to solid (melting point <= 140 deg C) substances are not available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no oxygen, fluorine or chlorine | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Organic compounds containing no bivalent -O-O- structure in the molecule | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 16 | Corrosive to metals | Not classified |
- |
- | - | It is not corrosive to metals (HSDB (Access on June 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 17 | Desensitized explosives | - |
- |
- | - | - | - | - |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity (Oral) | Category 4 |
 Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on reports of LD50 values for rats of 346.5 mg/kg (ECETOC JACC 19 (1991)), 378 mg/kg (female), 396 mg/kg (female), 402 mg/kg (male), 435 mg/kg (male) and 520 mg/kg (male) (the above DFGOT Vol. 5 (1993)), 590 mg/kg (male and female) and 820 mg/kg (male) (the above ECETOC JACC 19 (1991)), it was classified in Category 4. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | There are three reports of LD50 values for rabbits of 4,380 mg/kg (male), 4,990 mg/kg and 6,600 mg/kg (male) (all of them ECETOC JACC 19 (1991)), and two cases correspond to "Not classified" (Category 5 in UN GHS classification), one case corresponds to "Not classified." It was classified as "Not classified" (Category 5 in UN GHS classification) by adopting the category with the larger number of cases. The category was changed from the previous classification according to the GHS classification guidance for the Japanese government. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | It is a solid according to the GHS definition. Besides, an industrial product (purity 95% or above) is liquid because its melting point is 11-13 deg C. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
 Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Though it is a solid according to the GHS definition, an industrial product (purity 95% or above) is liquid because its melting point is 11-13 deg C. As for tests on an industrial product, there are five reports of LC50 values for rats of 359 ppm (male), 385 ppm (female) (both DFGOT Vol. 5 (1993), ECETOC JACC 19 (1991)), 660 ppm (ACGIH (7th, 2001)) from 4-hour inhalation tests, and 284 ppm (male) (converted 4-hour equivalent value: 348 ppm), 353 ppm (female) (converted 4-hour equivalent value: 432 ppm) (both ECETOC JACC 19 (1991)) from 6-hour inhalation tests. Four cases correspond to Category 2, and one case corresponds to Category 3. It was classified in Category 2 by adopting the category with the larger number of cases. Besides, because the exposure concentrations are lower than 90% of the saturated vapour pressure concentration (1,782 ppm), the reference values in the unit of ppm were applied as vapour with little mist. |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 2 | Skin corrosion/irritation | Category 2 |
Warning |
H315 | P302+P352 P332+P313 P362+P364 P264 P280 P321 |
Based on a report that it was moderately irritating in a skin irritation test with rabbits (ECETOC JACC 19 (1991)), it was classified in Category 2. Besides, this substance is classified in "Skin Irrit. 2" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 3 | Serious eye damage/eye irritation | Category 2B |
Warning |
H320 | P305+P351+P338 P337+P313 P264 |
Based on a report that in an eye irritation test with rabbits, this substance caused only slight corneal damage (ECETOC JACC 19 (1991)), it was classified in Category 2B. Besides, this substance is classified in "Eye Irrit. 2" in the EU CLP classification (ECHA CL Inventory (Access on June 2017)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 4 | Skin sensitization | Classification not possible |
- |
- | - | There is a report that in two skin sensitization tests with guinea pigs, both results were negative (ECETOC JACC 19 (1991), DFGOT Vol. 6 (1993)), however, it was classified as "Classification not possible" since information on humans could not be obtained. The category was changed from the previous classification according to the GHS classification guidance for the Japanese government. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is no data for in vivo. As for in vitro, bacterial reverse mutation tests, a chromosomal aberration test with mammalian cultured cells were negative (JECDB (Access on July 2017), SIDS (2002), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), DFGOT Vol. 5 (1993), PATTY (6th, 2012)). | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 7 | Reproductive toxicity | Category 2 |
 Warning |
H361 | P308+P313 P201 P202 P280 P405 P501 |
In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422), at a high dose (100 mg/kg/day) where suppression of weight gain and decreased food consumption were observed in maternal animals, all the fetuses from 2/10 of maternal animals died, and a decreased survival rate of newborns was observed (JECDB (Access on June 2017), SIDS (2002), Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). In addition, in a reproductive toxicity test with rats dosed by gavage for 16 weeks from one week before mating and during mating, at or above a middle dose (30 mg/kg/day), effects on the liver (an increase in liver weight, an increase in the incidence of clear cell foci) were observed, and at a high dose (100 mg/kg/day), effects on the next generation such as a 28% decrease in an F1 birth rate, low body weight of F1, and a high value of F1 mortality were observed (PATTY (6th, 2012)). On the other hand, in developmental toxicity tests with pregnant rats and pregnant rabbits dosed by gavage during the organogenesis period (gestational day 6-15 (rats), gestational day 6-19 (rabbits)), at doses (200 mg/kg/day or above in rats, 300 mg/kg/day or above in rabbits) where deaths were observed in maternal animals, only a slight effect on fetuses (low values of fetuses body weight) was observed in rats, and no statistically significant effect was observed in rabbits (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). From the above, since it is reported that in the two tests with rats, the survival rate of pups decreased at a dose where general toxicity manifested in parental animals, it was classified in Category 2. Besides, since new information sources after the previous classification were used, the classification result was changed. |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs), Category 3 (narcotic effects) |
Danger Warning |
H370 H336 |
P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
There is a report that in a 6-hour single inhalation exposure test with rats, nasal discharge, loss of coordination, tonic and clonic convulsions were observed. Though there is no description of the dose where the effects were observed, it is considered that they were observed near the LC50 values of 284 ppm (male) (converted 4-hour equivalent value: 348 ppm) or 353 ppm (female) (converted 4-hour equivalent value: 432 ppm) (equivalent to Category 1) (ECETOC JACC 19 (1991)). In addition, there is a report that in another 4-hour single inhalation exposure test with rats, at 1,000 ppm equivalent to Category 1, all the animals died (no description of day of deaths) after showing eye and nose irritation, dyspnea, loss of coordination, tremors, and hyperesthesia, and on autopsy, congestions were observed in the lung, liver and kidney (DFGOT Vol. 5 (1993)). As for the oral route, there is a report that in a single oral dose test with rats, hunched posture, lethargy, piloerection, decreased respiration rate, and reddish brown discoloration around the nose were observed, and on autopsy, bleeding in the lungs, darkening of the liver, and sloughing of the gastric epithelium were observed. It was described that fatal cases died on the day of administration, however, cases that recovered showed normal appearance the day after administration. Though there is no description of the dose where the effects were observed, it is considered that they were observed near the LD50 value of 590 mg/kg (equivalent to Category 2) (ECETOC JACC 19 (1991)). As for the dermal route, there is a report that in a single dermal exposure test with rats, at 2,000 mg/kg of upper limit of Category 2 under the occlusion condition for 24 hours, hunched posture, lethargy, piloerection, ptosis, and reddish brown discoloration around the nose (in some cases) were observed, however, the symptoms disappeared after two days, and no deaths occurred (ECETOC JACC 19 (1991)). By integrating the above information, it is considered that this substance affects the central nervous system and respiratory organs, and it shows narcotic effects. Since the effects were observed at doses within the range for Category 1 in the inhalation exposure tests, it was classified in Category 1 (central nervous system, respiratory organs), Category 3 (narcotic effects). Though the liver and kidney were determined as target organs in the previous classification, the congestions in the liver and kidney observed in the autopsy findings were not adopted because they were considered to be not sufficient as evidence of the classification. Therefore, the classification result was changed. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (respiratory organs, liver) |
Warning |
H373 | P260 P314 P501 |
As for humans, there is a report that headache was observed for the first two months in persons exposed to the vapor of this substance for five months, however, as no symptoms were observed for the following three months, it is considered to be due to habituation (ECETOC JACC 19 (1991)). As for experimental animals, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats dosed by gavage (OECD TG 422), at or above 4 mg/kg/day (converted guidance value: 2 mg/kg/day) which is within the guidance value range for Category 1, lesions of the kidney specific to male rats were observed in males, at or above 20 mg/kg/day (converted guidance value: 9.8 mg/kg/day), increased fatty droplets in the fascicular zone of the adrenals were observed, and at or above 100 mg/kg/day (converted guidance value: male 48.9 mg/kg/day, female 45.6 mg/kg/day) which is within the guidance value range for Category 2, increased GOT (AST) and GPT (ALT), increased liver weight, enlargement of the liver, single cell necrosis in the liver, fading in the kidney, multiple grayish white points, adrenal enlargement, etc., were observed in males, and increased fatty droplets in the fascicular zone of the adrenals were observed in females (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013), JECDB (Access on June 2017), SIDS (2002)). In a 28-day repeated oral dose toxicity test with rats dosed by gavage, at or above 40 mg/kg/day (converted guidance value: 12 mg/kg/day) which is within the guidance value range for Category 2, suppression of weight gain, increased GPT (ALT), decreased chlorine or A/G ratio, increased kidney weights were observed, at 200 mg/kg/day (converted guidance value: 62 mg/kg/day), deaths, increased hematocrit value and mean corpuscular volume, increased GOT (AST), increased relative weight of the liver, increased absolute and relative weight of the adrenal gland, enlargement of the adrenal cortex, and foamy substances in the hepatocytes (hydropic degeneration or fatty degeneration), etc. were observed (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). In a 18-week inhalation toxicity test with rats (7 hours, 5 days/week), within the guidance value range for Category 2 (vapor), at or above 190 mg/m3 (0.22 mg/L), lesions of the kidney specific to male rats were observed in males, at 399 mg/m3 (converted guidance value: 0.47 mg/L), acicular calcification was observed in females, and chronic pneumonia and bronchiectasis were observed in males (Environmental Risk Assessment for Chemical Substances Vol.11 (Ministry of the Environment, 2013)). Of the above, the effects observed in the male kidney are specific findings in male rats, the toxicological significance of the increased fatty droplets in the fascicular zone of the adrenals glands was unknown, acicular calcification observed in females in the inhalation test was not adopted as an effect in other multiple evaluation reports (DFGOT Vol. 5 (1993), ECETOC JACC 19 (1991)). Therefore, they were not adopted as evidence for the classification (DFGOT Vol. 5 (1993), ECETOC JACC 19 (1991)). Therefore, it was classified in Category 2 (respiratory organs, liver). Besides, as for the effects on the kidney in males and congestion and bleeding in the organs in death cases, which were used as evidence for the classification for the kidney and for the circulatory system, respectively, in the previous classification, they were reviewed and not adopted as evidence. Thus, the classification was changed. |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
|---|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment Short term (Acute) | Category 2 |
- |
H401 | P273 P501 |
From 48-hour EC50 (immobile) = 4.2 mg/L for crustacea (Daphnia pulex) (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)), it was classified in Category 2. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 11 | Hazardous to the aquatic environment Long term (Chronic) | Category 2 |
 - |
H411 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified as "Not classified" due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 0% (J-CHECK, 1980)), and 21-day NOEC (reproduction inhibition) = 3.2 mg/L for crustacea (Daphnia magna) (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to being not rapidly degradable (non-biodegradable, a degradation rate by BOD: 0% (J-CHECK, 1980)), and 96-hour LC50 = 4.3 mg/L for fish (Oryzias latipes) (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013)). From the above results, it was classified in Category 2. |
FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
| 12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | No data available. | FY2017 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1)) |
NOTE:
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