NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	77-78-1
Chemical Name	Dimethyl sulfate
Substance ID	m-nite-77-78-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Category 4	- Warning	H227	P370+P378 P210 P280 P403 P501	It was classified in Category 4 from a flash point of 83 deg C (closed cup) (ICSC (2008) (J), GESTIS (Accessed Jan. 2019)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive or self-reactive properties present in the molecule.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified	- -	-	-	Flash point: 188degC (Weiss, 2nd, 1986, p400)	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Containing no -0-0- structure	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Not classified	- -	-	-	UNRTDG Class: 6.1	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 3	Danger	H301	P301+P310 P264 P270 P321 P330 P405 P501	Calculated based on rat oral LD50 values = 440mg/kg (CERI Hazard Data (1999), EHC 48 (1985), EU-RAR (2002)), 1450mg/kg (CERI Hazard Data (1999)), 205mg/kg (EHC 48 (1985), EU-RAR (2002)), and 106mg/kg (EU-RAR (2002)). Since the calculated values was 188.1mg/kg, it was set as Category 3.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Judging it as vapor from its vapor pressure. Calculated based on rat inhalation LC50 (1 hour) = 64ppm (4 hour equivalent: 0.168mg/L) (CERI Hazard Data (1999), EHC 48 (1985), DFGOT vol4 (1992)), 0.335mg/L (4 hour equivalent: 0.168mg/L) (EU-RAR (2002)), LC50 (4 hours) = 9ppm (equivalent 0.05mg/L) (CERI Hazard Data (1999)), 0.045mg/L (EHC 48 (1985), EU-RAR (2002)) and 0.168mg/L (EU-RAR (2002)). Calculated value is 0.0748mg/L, and it was classified as Category 1 based on the equivalent of this value at 14ppm.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	Based on descriptions that it has strong irritative and corrosive effect on human skin (CERI Hazard Data (1999)) and that necrosis was seen in rabbit skin application test (CERI Hazard Data (1999), EU-RAR (2002)), it was classified as Category 1A-1C.	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	From description that it had strong stimuli and corrosive effect to an eye and the skin in humans (CERI Hazard Data(1999)), and from description that severe irritation was acknowledged by apply to the eye of the rabbit (CERI Hazard Data (1999) and EU-RAR (2002)), it was set as Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	In the dominant lethality test using the mouse it gave negative (EHC 48 (1985), EU-RAR (2002) and CERI Hazard Data (1999)), however, it gave positive in the chromosomal aberration test (IARC 71 (1999) EHC 48 (1985) and CERI Hazard Data (1999)) using myeloid cells of rat and mouse, positive in the mouse spot test (EHC 48 (1985), CERI Hazard Data (1999)) and negative (EU-RAR (2002)). And it gave positive in the chromosomal aberration test (EHC 48 (1985), CERI Hazard Data (1999)) using the rat and the mouse peripheral lymphocytes, and positive in the chromosomal aberration test (IARC 71 (1999)) using the fetal mouse, and there was no report of the in vivo genotoxicity examination with the productive cells. So we classified it as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1B	Danger	H350	P308+P313 P201 P202 P280 P405 P501	It is classified into A3 according to ACGIH (7th, 2001) and is classified into B-2 according to EPA (2005). And it is classified into 2A according to IARC 71 (1999), into 2 according to EU (2005), and into 2A according to Japan Society for Occupational Health (2005). Therefore, it was set as category1B.	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	Since although fetotoxicity was clearly observed at hygh dose exposure test in inhalation exposure tests to rats and mice in all pregnant period or 1-13 days of pregnant (EHC 48 (1985), ACGIH (7th, 2001) and the CERI hazard data collection(1999)), details of the test method and effects on mother animals are not clear, therefore, it was classified into Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory system, central nervous system, liver, kidney, heart), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	According to the descriptions that pulmonary edemas and respiratory disorders are identified in human exposure cases (CERI Hazard Data (1999), EHC 48 (1985), ACGIH (7th, 2001), DFGOT vol4 (1992) and EU-RAR (2002)), that effects on the central nerve systems such as convulsion, coma and paralysis are observed in human exposure cases (CERI Hazard Data(1999), EHC 48 (1985), ACGIH (7th, 2001)), and that kidney or liver tardive or cardiac delayed disorder were observed in human exposure cases (EHC 48 (1985) and ACGIH (7th, 2001)). So it was judged that the target organs were respirstory systems, central nerve systems, kidney, liver and cardiac, and they were all set as Category 1. In addition, such irritant as inflammation of the upper respiratory tract etc., has been identified in low concentrations, too. It was set as Category 3 (respiratory irritant).	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 2 (lung)	Warning	H373	P260 P314 P501	Since there was description in the ICSC (J)(1995) that lungs may be risked by effect of repeated exposure, it was judged that lungs were target organ, and classified to as Category 2.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 3	- -	H402	P273 P501	It was classified in Category 3 from 96-hour LC50 = 15 mg/L for fish (Menidia beryllina) (EU RAR: 2002). The effects of both this substance and its decomposition products were used for classification.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	Chronic toxicity data were not obtained. It was classified as "Not classified" due to rapid degradability (readily biodegradable, judged by comparison with degradability of related compounds (J-CHECK, 2012)), and no bioaccumulation estimate (LogKow: 0.16 (EST, PHYSPROP Database: 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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