NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	770-35-4
Chemical Name	1-Phenoxy-2-propanol
Substance ID	m-nite-770-35-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified	- -	-	-	It was classified as "Not classified" because a flash point of 120 deg C (closed cup) (SIDS (2006)) is above 93 deg C.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified	- -	-	-	It is estimated that it does not spontaneously ignite at normal temperatures from an autoignition temperature of 490 deg C (SIDS (2006)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to liquid substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	The substance is an organic compound containing oxygen (but not fluorine or chlorine) which is chemically bonded only to carbon or hydrogen.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Organic compounds containing no bivalent -O-O- structure in the molecule.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	It was classified as "Not classified" in the Classification JIS (Category 5 in UN GHS classification) based on reports of LD50 values for rats of 2,830 mg/kg (males) and 3,730 mg/kg (females) for the commercial product (purity 93% at minimum) consisting of this substance (> 85%) and its isomer, 2-phenoxypropan-1-ol (CAS RN 4169-04-4) (< 15%) (SIDS (2006), PATTY (6th, 2012)). Besides, the classification was conducted assuming that the toxicity of purities and the isomer less than 15% is comparable to that of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified	- -	-	-	It was classified as "Not classified" based on reports on an LD50 value of > 2,000 mg/kg for rabbits on the commercial product (purity 93% at minimum) consisting of this substance (> 85%) and its isomer, 2-phenoxypropan-1-ol (CAS RN 4169-04-4) (< 15%) (SIDS (2006), PATTY (6th, 2012)). Besides, the classification was conducted assuming that the toxicity of purities and the isomer less than 15% is comparable to that of this substance.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Liquid (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	It was classified as "Not classified" based on reports of an LC50 value (4-hour inhalation of aerosol) for rats of > 5.4 mg/L (OECD TG403) for the commercial product (purity 93% at minimum) consisting of this substance (> 85%) and its isomer, 2-phenoxypropan-1-ol (CAS RN 4169-04-4) (< 15%) (SIDS (2006), PATTY (6th, 2012)). Besides, by assuming that the toxicity of purities and the isomer less than 15% is comparable to that of this substance, because the test concentration is higher than the saturated vapour concentration (0.0426 mg/L), and due to the description of aerosol, a reference value in the unit of mg/L was used for the classification.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Not classified	- -	-	-	It was classified as "Not classified" because no irritation was observed in a skin irritation test with rabbits according to OECD TG 404 (SIDS (2006))	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	In a Draize test with rabbits (OECD TG 405), it was assessed to be irritating (SIDS (2006)). Corneal opacity, conjunctival redness, and chemosis were observed as findings, and even after 23 days, the animals showed corneal opacity and conjunctival redness and did not fully recover. Therefore, it was classified in Category 1.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Not classified	- -	-	-	It is reported in SIDS (2006) that it was negative in a Buehler test with guinea pigs (OECD TG 406). Because the test complies with the OECD test guideline as to the number of animals in a test group (20), a method of applying test substance, etc., it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was assessed to be negative in a micronucleus test with mouse bone marrow cells (SIDS (2006)). As for in vitro, it was negative in a bacterial reverse mutation test and a chromosomal aberration test with peripheral blood lymphocytes of humans (SIDS (2006)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, no effects on fertility were observed in a two-generation reproductive toxicity test with rats in the oral route (drinking water). At the dose where parent toxicity (weight gain reduction, decreases in food consumption and water consumption) was found, decreases in body weight and organ weights and retardation in sexual maturation were observed in offspring, but no effects on fertility after sexual maturation were found (SIDS (2006), PATTY (6th, 2012)). In a developmental toxicity test with rabbits in the oral route (gavage), at the dose where maternal toxicity (weight gain reduction, decreased food consumption, apathy, lateral position, euthanization (1/15 animals)) was seen, skeletal variations but no malformations were observed (SIDS (2006), PATTY (6th, 2012)). Because the above findings are slight changes in developmental parameters, they were not adopted as evidence of the classification.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 3 (narcotic effects, respiratory tract irritation)	Warning	H336 H335	P304+P340 P403+P233 P261 P271 P312 P405 P501	In gavage administration to rats (SIDS (2006), PATTY (6th, 2012)), staggering, atonia, paresis, loss of pain reflex, and loss of corneal reflex were observed within the range of Category 2 (1,000-2,000 mg/kg), but they were reversible. Therefore, it was classified in Category 3 (narcotic effects). Besides, because respiratory tract irritation and temporary breathing difficulties were observed after exposure to mist (5.4 mg/L) by inhalation in rats (PATTY (6th, 2012), SIDS (2006)), it was classified in Category 3 (respiratory tract irritation).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data. Besides, it is described that in 26-week diet administration test with rats, reduced weight gain was observed at the dose (478 mg/kg/day) above the range of Category 2, but toxicity effects were not found within the range for Category 2 (SIDS (2006), PATTY (6th, 2012)), and in a 28-day dermal administration test with rabbits, systemic toxicity effects were not observed at up to the maximum dose (1,000 mg/kg/day: 333 mg/kg/day (converted guidance value)) (SIDS (2006), PATTY (6th, 2012)), Therefore, it corresponds to "Not classified" in the oral and dermal routes. However, because there is no information on the inhalation route, it was classified as "Classification not possible" due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	From 72-hour ErC50 > 100 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006), 48-hour LC50 = 370 mg/L for crustacea (Daphnia magna) (SIDS, 2006), and 96-hour LC50 = 280 mg/L for fish (Pimephales promelas) (SIDS, 2006), it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Not classified	- -	-	-	If chronic toxicity data are used, then it is classified as "Not classified" due to rapid degradability (a 28-day degradation rate by BOD = 72% (SIDS, 2006)), and 72-hour NOEC = 12.5 mg/L for algae (Desmodesmus subspicatus) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity for both crustacea and fish, and it is not water-insoluble (water solubility = 11000 mg/L (SRC, 2013)). From the above results, it was classified as "Not classified."	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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