NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7704-34-9
Chemical Name	Sulfur
Substance ID	m-nite-7704-34-9_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Category 2	Warning	H228	P370+P378 P210 P240 P241 P280	Classified into Category 2 since the substance is classified into Division 4.1, PG III in UNRTDG (UN1350).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	Auto-ignition point is 232 degC (NFPA (13th, 2006)) exceeding 70 degC.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	Test methods applicable to solid (melting point <= 140 degC) substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	The substance does not contain oxygen, fluorine or chlorine.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	Based on LD50 values of >5000 mg/kg, >5000 mg/kg, and >3000 mg/kg for rats (IUCLID (2000)), the substance was classified into "Not classified".	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Based on a LD50 value of >2000 mg/kg for rats (IUCLID (2000)), the substance was classified as "Not classified" in JIS Classification (correspond to Category 5 or "Not classified" in GHS classification).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Based on a LC50 value of >9.23 mg/L for rats (IUCLID (2000)), the substance was classified as "Not classified". Since the value (9.23 mg/L) was higher than the saturated vapour pressure concentration (0.0007 mg/L (30.4 degC)), the test was considered to be conducted for dust.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Not classified	- -	-	-	Based on a result of not irritating in a rabbit irritation test (OECD TG404 (GLP)) where irritation score was "0" in all rabbits after application of 80% wettable powder to the skin (IUCLID (2000)), the substance was classified as "Not classified". In another rabbit test with 75% wettable powder, a result of "mildly irritating" or "hardly irritating" was obtained (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1994)). In EU classification, the substance is classified into Xi: R38 (EU-Annex I (2009)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Not classified	- -	-	-	Based on a result of not irritating in a rabbit irritation test (OECD TG405 (GLP)) where irritation score was "0" in all rabbits after application of 80% wettable powder to the eye (IUCLID (2000)), the substance was classified as "Not classified". In another rabbit test with 75% wettable powder, the result of "mildly irritating" or "hardly irritating" was obtained (Pesticide safety information (Japan Crop Protection Association) (List open for the public) (1994)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although there is a result of "not sensitizing" in human patch test (IUCLID (2000)) and information of not sensitizer in a guinea pig test (EPA RED (access on Aug. 2009)), the details are not clear.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Although induction of chromosome aberrations in germ cell of guinea pigs and induction of chromosome damage in rat embryos were observed (IUCLID (2000)), these tests are invalid since the experimental procedures are not commonly used and the detailed data are not clear. Additionally, there is a negative result in a rat bone marrow chromosome aberration test (IUCLID (2000)), but the detailed data are unclear. Therefore, classification was not possible due to lack of appropriate data from in vivo mutagenicity tests. As relevant information, from in vitro mutagenicity tests, there is a report of a negative Ames test (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory tract)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It is reported that exposure to sulfur particulates produces tracheobronchitis, characterized by cough, sore throat, and chest pain in humans (PATTY (5th, 2001)). Additionally, it is reported that acute effects of sulfur inhalation include catarrhal inflammation of nasal mucosa, which may lead to hyperplasia and tracheobronchitis is a frequent occurrence with dyspnea, persistent cough and expectoration which is sometimes streaked with blood (HSDB (2003)). Based on these information, the substance was classified into Category 1 (respiratory tract). As relevant information, dyspnea was observed by oral administration to rats at 1000 mg/kg and more (IUCLID (2000)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 2 (respiratory system, skin)	Warning	H373	P260 P314 P501	It is reported that workers exposed to atmospheric sulphur for 2.0 - 2.5 years exhibited frequent nosebleeds, bronchitis and impaired lung function (IUCLID (2000)). Additionally, it is reported that mine workers exposed to sulfur dust and sulfur dioxide often had chronic sinus effects and respiratory disturbances. Based on this information found in a document in List 2, the substance was classified into Category 2 (respiratory system). There are reports that development of comedones was reported in some workers exposed to sulfur dust (IUCLID (2000)) and skin may be subject to erythematous and eczematous lesions and signs of ulceration in workers whose hands are in prolonged or repeated contact with powdered sulfur (HSDB (2003)). There is a report of an animal test where dermal application of 10% test substance to rabbits for 2 weeks resulted in hyperkeratosis and formation of comedones (IUCLID (2000)). Based on this information found in a document in List 2, the substance was classified into Category 2 (skin).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Not classified	- -	-	-	Classified into Not classified from its 96h-LC50 = 736 mg/L for Crustacea (Mysid) (AQUIRE, 2010)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	Classified into Classification not possible since data on rapid degradation and quantitative data on water solubility are not obtained though its acute toxicity is Not classified.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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