Item | Information |
---|---|
CAS RN | 7726-95-6 |
Chemical Name | Bromine |
Substance ID | m-nite-7726-95-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2009)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified |
- |
- | - | It is not combustible (ICSC (2009)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2009)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Classification not possible |
- |
- | - | It is a halogen substance, but the classification is not possible due to no data. Besides, it is described (ICSC (2009)): it is a strong oxidant and reacts violently with combustible or reducing substances; it reacts most organic and inorganic compounds, causing fire and explosion hazard; it attacks metal, some forms of plastic, rubber, and coatings. However, because it is classified in Class 8, Subsidiary Risk 6.1, PG I (UN1744) in UNRTDG, and Subsidiary Risk 5.1 was not given, it is estimated to correspond to "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic substance. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Category 1 |
Warning |
H290 | P234 P390 P406 |
There are no test data, but because it reacts violently with aluminum, mercury, and titanium (Bretherick (J) (1998)), it was judged to meet the criteria for corrosivity. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified |
- |
- | - | Based on reports of LD50 values of 2,600 mg/kg (IUCLID (2000), HSDB (Access on September 2014)) and 3,100 mg/kg (HSDB (Access on September 2014)) for rats, it was classified as "Not classified" (Category 5 in UN GHS classification). Due to changes in the priority of information sources in the GHS Classification Guidance for the Japanese Government, an LD50 value (1700 mg/kg (RTECS (2004))) in the previous evidence of the classification was replaced with the value in high-priority new information sources (IUCLID (2000), HSDB (Access on September 2014)), and the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Liquid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
Based on reports of LC50 values of 240 ppm (60 minutes) (converted 4-hour equivalent value: 120 ppm) and 240 ppm (90 minutes) (converted 4-hour equivalent value: 155 ppm) for mice (ACGIH (2001)), it was classified in Category 2. Besides, although there is a report of an LC50 value of 750 ppm (9 minutes) (converted 4-hour equivalent value: 46.5 ppm) for mice (ACGIH (2001)), it was not adopted because the exposure time was short. Because the LC50 values were lower than 90% of the saturated vapour concentration (230,010 ppm), the reference value in units of ppm was applied as a vapour without a mist. According to the GHS Classification Guidance for the Japanese Government, data with an exposure time close to 4 hours were prioritized, and the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There is a description that the vapour of this substance is extremely irritating to the skin of humans (ACGIH (7th, 2001)), and that it damages skin tissue and there is a report that formation of blisters and pustules were observed in humans exposed to this substance (PATTY (6th, 2012)). In addition, although there is a report that it was irritating in rats, details such as test conditions were unknown (IUCLID (2000)). From the above, based on the report of extreme irritation in humans, it was classified in Category 1. Besides, this substance is classified as "C; R35" in the EU DSD classification, and as "Skin Corr. 1A H314" in the EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There are descriptions that this substance is a severe eye irritant (ACGIH (7th, 2001)), and that the vapour of this substance is extremely irritating to human eyes (ACGIH (7th, 2001), HSDB (Access on September 2014)). In addition, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, although there is a report of respiratory difficulty with symptoms of asthmatic bronchitis in humans (ACGIH (7th, 2001)), details such as the number of cases were unknown, therefore, these data were judged as insufficient for use in classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory organs) |
Danger |
H370 | P308+P311 P260 P264 P270 P321 P405 P501 |
This substance is extremely irritating to the respiratory tract (OEL Documentations (Japan Society For Occupational Health (JSOH), 1964), ACGIH (7th, 2001), PATTY (6th, 2012)). There were reports that coughing, epistaxis, bronchopneumonia, chemical burns in the lungs, severe injuries in the lungs and trachea, pulmonary edema, headache, dizziness, nausea, respiratory difficulty, photophobia, blepharospasm, abdominal pain and diarrhea occurred by the inhalation exposure to the vapour (ACGIH (7th, 2001), PATTY (6th, 2012), OEL Documentations (Japan Society For Occupational Health (JSOH), 1964)). As for experimental animals, functional central nervous system disturbance, lung edema and hemorrhages of the gastric mucosa were observed by inhalation exposure in rabbits and guinea pigs to 300 ppm (1.96 mg/L) of the vapour (ACGIH (7th, 2001)). These symptoms in experimental animals were observed at a concentration within the range corresponding to Category 1. From the above, this substance was considered to affect the central nervous system and respiratory organs, and it was classified in Category 1 (central nervous system, respiratory organs). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (nervous system, respiratory organs, endocrine system) |
Danger |
H372 | P260 P264 P270 P314 P501 |
It is described in IPCS that this substance is potentially capable of damage to the respiratory organs (interstitial pulmonary fibrosis, emphysema, airway hyperreactivity) (IPCS PIM 80 (1999)). However, the cited effects on the respiratory organs were considered to be secondary to acute exposure to this substance (Lossos, I.S. et al. (1990), Kraut, A. and Lilith, R. (1988)). On the other hand, as for experimental animals, details were not confirmed because it was hard to obtain the original source, however, there are the following reports of repeated exposure tests by the inhalation and the oral route. It was described that disturbances in the functions of the "respiratory system," "nervous system" and "endocrine system" occurred in an inhalation exposure test in which rats, mice and rabbits were exposed to this substance at 0.2 ppm for 4 months (note: although this finding was described as the exposure at 2 ppm in the ACGIH (7th, 2001), it was determined that 0.2 ppm was incorrectly described as 2 ppm) (PATTY (6th, 2012), ACGIH (7th, 2001)). From the results of this test, assuming exposure to the vapour, the exposure time was unknown due to no description, however, the effect concentration (0.2 ppm=1.3 mg/m3 (0.0013 mg/L)) was clearly considered to be within the guidance value range for Category 1. Moreover, there was a description that altered behavior and lower cholinesterase activity were observed in a test in which rats were given this substance in drinking water for 6 months at a dose corresponding to 0.01 mg/kg (ACGIH (7th, 2001)), therefore, it was considered to be findings supporting effects on the nervous system. From the above, based on hazardous findings on humans and experimental animals, it was classified in Category 1 (nervous system, respiratory organs, endocrine system). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified into Category 1 from 48-hour LC50=1000microg/L of Crustacea (Daphnia magna) (AQUIRE, 2003). | FY2006 | GHS Classification Manual (10 Feb, 2006) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown. | FY2006 | GHS Classification Manual (10 Feb, 2006) |
12 | Hazardous to the ozone layer | - |
- |
- | - | - | - | - |
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