NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7727-21-1
Chemical Name	Dipotassium peroxodisulfate
Substance ID	m-nite-7727-21-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Although the "adjacent oxygen atom" associated with explosive properties is included, it was classified into Not classified because it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible inorganic compounds.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible inorganic compounds.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Category 3	Warning	H272	P370+P378 P210 P220 P280 P501	Since it was classified into Class 5.1 and PG III in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1492(ICSC, 2002)), it was classified into Category 3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	It was classified into Category 4 from LD50 value 1,130 mg/kg (male) (SIDS (2005), NICNAS (2001), IUCLID (2000)) of the oral administration test employing a rat. In addition, in EU classification, it is Xn; R22 (EU-Annex I) and is equivalent to Category 3-4.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Not classified	- -	-	-	Since LD50 value of the dermal administration test employing rats was >10,000 mg/kg (SIDS (2005), NICNAS (2001)), it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified	- -	-	-	Since it is written that LC50 value of 1-hour inhalation exposure test employing rats is >42.9 mg/L (SIDS (2005), IUCLID (2000)), 4-hour equivalent LC50 value is >10.7 mg/L when applying the dust standard due to a solid. Therefore, it was classified into "Not classified".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Category 2	Warning	H315	P302+P352 P332+P313 P362+P364 P264 P280 P321	For animals, although "not irritating" has been described in the skin irritation test with rabbits (SIDS (2005)), the details including exposure time are unknown. For humans, there is a description of "irritative" in the test in which a 17.5% solution of this substance was applied for 4 hours (SIDS (2005)). For humans, SIDS (2005) has described "can cause skin irritation" in 5% or more solution of this substance as a conclusion. Therefore, it was classified into Category 2. In addition, it can be classified as Xi in the EU classification; R36/ 37/ 38 (EU-Annex I), being equivalent to Category 2-3.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	For animals, there is a description of "It is the eye irritation test employing eight rabbits and any of average score value in the cornea, the iris, and the conjunctiva is 0."(SIDS (2005)). Moreover, in NICNAS (2001), there is a description of "marginal irritation to rabbit eyes" about the same test. Furthermore, although SIDS (2005) has a description of "Peroxydisulfuric are harmful to human eyes", since other data cannot be found, classification is not possible due to insufficient data. In addition, the EU classification is Xi; R36/37/38 (EU-Annex I), and is equivalent to Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	For humans, it has been described that "2, 3, and 3 of 52 persons of manufacturing factory employees were positive to this substance alone, the related substance of Diammonium salt (CAS No.7727-54-0) alone, and both of this substance and Diammonium salt, respectively. The correlation trend was indicated between positive results and slight decrease of lung function." in vivo immunological test (skin prick test) (SIDS (2005)). Moreover, there is also a report of occupational asthma in beauticians, and it has been concluded that "test results in humans show that the substance is a respiratory sensitizer in occupational exposure"in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	For humans, it has been described in SIDS (2005) that there are two positive reports including one in study auxiliary service and another in beauticians in the patch test to which a 2.5% solution of the substance was applied. Moreover, about the relative substance of diammonium salt (CAS No.7727-54-0), it has been described that "eczema, skin diseases, and pimples were developed" (SIDS (2005)) or that "allergic dermatitis was observed" (NICNAS (2001)) as occupational exposures in beauticians, and it has been concluded that "test results in humans show that the substance is a skin sensitizer in occupational exposure" in SIDS (2005). As mentioned above, it was classified into Category 1. In addition, it can be classified as Xi; R42/43 (EU-Annex I) in the EU classifications, which is equivalent to Category 1.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	Classification is not possible because there is no data. In addition, there is a description of "negative" in the in vivo mutagenicity test (micronucleus test employing mouse erythrocyte) and in the in vivo genotoxicity test (UDS test using rat hepatocytes), respectively, for Disodium peroxydisulfate (CAS No.7775-27-1) which is a substance (SIDS (2005), NICNAS (2001)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Classification not possible	- -	-	-	Since no evaluation by major international evaluation agencies is made and there is no data, classification is not possible. In addition, it is recommended to refer also to the category result of the Diammonium salt (CAS No.7727-54-0) which is a relative substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification is not possible because there is no data. Refer to the classification result of a related substance, Diammonium salt (CAS No.7727-54-0).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 2 (systemic), Category 3 (respiratory tract irritation)	Warning	H371 H335	P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312	The single-dose studies which calculates oral lethal dose of rats has a description that "a hypoactivity (depression), shallow breathings (weak breathing), and respiratory distress were acknowledged. Such symptoms were recovered within four days in live animals" (SIDS (2005)). This impact was seen within the limits of the guidance value of Category 2. Moreover, there is also a description of "nasal discharges and dyspnea" (SIDS (2005)) as human impacts. As mentioned above, it was classified into Category 2 (systemic toxicity) and Category 3 (Respiratory tract irritation). In addition, it is recommended to also refer to the category result of the Diammonium salt (CAS No.7727-54-0) which is a relative substance.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In the 28-day repeated oral administration test to male rats, there is the description that "no toxic effect was detected" (SIDS (2005)), but the details are unknown because the data is non-public. Since there is no other test data, classification is not possible because of lack of sufficient data. In addition, also refer to the classification result of the related substance, Diammonium salt (CAS No.7727-54-0).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	Reliable acute toxicity data were not obtained.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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