NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7758-01-2
Chemical Name	Potassium bromate
Substance ID	m-nite-7758-01-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified	- -	-	-	Although the atom group (O-halogen) concerning explosiveness is included, it was classified into Not classified because it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods(UN No.1484 (ICSC,2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Flammable solids	Not classified	- -	-	-	Since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1484(ICSC,2003)), it was classified into Not classified.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Self-reactive substances and mixtures	Not classified	- -	-	-	Although the atom group (O-Br) associated with explosive properties is included, it was classified into Not classified, since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1484(ICSC2003).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Pyrophoric solids	Not classified	- -	-	-	Non-combustible (ICSC(2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Non-combustible (ICSC(2003)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) are not included.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
14	Oxidizing solids	Category 2	Danger	H272	P370+P378 P210 P220 P280 P501	Since it was classified into Class 5.1 and PG II in the United Nations Recommendations on the Transport of Dangerous Goods (UN No.1484(ICSC,2003)), it was classified into Category 2.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	There is a description of LD50 value 400-500 (495) mg/kg (IARC 73 (1999), JECFA (1992)), and 160-190 mg/kg (JECFA (1992)) of the oral administration test employing a rat. These values were classified into Category 4 from the description that "They are male:400 (348-460) mg/kg and female:495 (446-549) mg/kg as a result of carrying out statistics processing of the LD50 value." in information from same reference (Environ.Health Perspect.87 (1990)).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Since it was a solid by the definition of GHS and inhalation in gas was not assumed, it was classified into "Not applicable".	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Although there is a description saying, "Prolonged contacts of Bromate cause burns on the scarf skin of rabbits but they recover in a few days,"(Patty (5th, 2001)), classification is not possible because there is no information at the time of 4- hour exposure. Incidentally, there is a description, "It stimulates the skin, "in the section of the Effect of Short Term Exposure in ICSC (2006).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
3	Serious eye damage/eye irritation	Category 2B	- Warning	H320	P305+P351+P338 P337+P313 P264	From the description that "Although Bromate causes moderate irritation and slight corneal injury in eyes of of a rabbit, it will recover in several days " (Patty 5th, (2001)), it was classified into Category 2B. In addition, there is a description of "Eyes are stimulated." in the paragraph of short-term exposure effects of ICSC (2003).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
4	Skin sensitization	Classification not possible	- -	-	-	Classification is not possible since there is no data.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	Although there is a description of "positive" (IARC 73 (1999), JECFA (1992), IRIS (2001)) in the body cell in vivo mutagenicity test (micronucleus test employing the bone marrow cell and erythrocyte of the mouse, the chromosome aberration test using the marrow cells of the rat), since there was no positive finding of the productive cell in vivo genotoxicity test, it was classified into Category 2. In addition, for the body cell in vivo genotoxicity test IARC 73 (1999), there are descriptions of "positive" in the DNA damage test employing the kidney of the rat, "Slightly positive to negative" (IARC 73 (1999)) in the DNA damage test employing the liver of the rat, and "positive" in either of the in vitro mutagenicity test (chromosome aberration test employing CHL culture cells and the reverse mutation test employing a Salmonella typhimurium).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
6	Carcinogenicity	Category 2	Warning	H351	P308+P313 P201 P202 P280 P405 P501	IARC evaluates it as group 2B (IARC 73 (2000)), and the European Union classification evaluates it as Carc. Cat. 2; R45 (EU-Annex I). According to guidance, priority was given to the classification of IARC and it classified into Category 2. In addition, ACGIH (7th, 2001) has a description of "EPA classification of Bromate: L (oral), B-2."	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
7	Reproductive toxicity	Classification not possible	- -	-	-	Classification is not possible because there is no data. Incidentally, GHS Classification of the related compound, Sodium bromate is "Not classified" based on results of the multi-generation reproductive toxicity study via administration of drinking water using male and female rats.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
8	Specific target organ toxicity - Single exposure	Category 1 (kidney, central nervous system, gastrointestinal system, blood system), Category 3 (respiratory tract irritation)	Danger Warning	H370 H335	P308+P311 P260 P264 P270 P321 P405 P501 P304+P340 P403+P233 P261 P271 P312	As for toxic symptoms of Bromate Anemia, there is a description that "hemolysis, kidney trouble, and hardness of hearing" were seen in humans who did oral ingestion of the solution containing this article (EHC 216 (2000), IRIS (2001), JECFA (1992)), and another description that "Vomiting, abdominal pain, and diarrhea were seen as irritant effect on the gastrointestinal effect, and a lethargy dizziness, low blood pressures a hypotonia (hypotonicity), and reflexes absents were seen as central nervous system effect" (IRIS (2001), JECFA (1992)). Moreover, the paragraph of short-term exposure effects of ICSC (2003) has a description that "a respiratory tract is stimulated. The kidney and a central nervous system may be affected and kidney insufficiency, respiratory depression, and hardness of hearing may be produced when oral ingestion is carried out." As mentioned above, it was classified into Category 1 (kidney, central nervous systems, digestive system, blood systems) and Category 3 (Respiratory tract irritation).	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
9	Specific target organ toxicity - Repeated exposure	Classification not possible	- -	-	-	In the 13-week study of administration in drinking water to male and female rats, "on blood biochemical findings, an increase in GOT, GPT, LDH, ALP, BUN, serum sodium and cholinesterase were observed in male and female rats, and droplet in proximal tubule epithelial cytoplasm and a broad range of reproductive changes in kidney tubule were observed in male rats" (IRIS (2001), JECFA (1992)). Moreover, in the 100-week study of administration in drinking water to male rats and male mice (IRIS (2001)), on findings in rats "a statistically significant reduction of drinking water intake was observed in the high-dose group, but any other effects associated with the dose were not observed," and "a dose-dependent increase in the incidence rate of urothelium hyperplasia, mineral deposits in kidney papillary and eosinophilic droplet in proximal tubular epithelium were observed." In the 12-week study of administration in drinking water to male rats, "the droplets observed in kidney tubule are concluded to be more of eosinophilic bodies than hyaline droplets" (EHC 216 (2000), JECFA (1992)). The kidney symptoms were observed only in male rats and considered as the effects by alpha2u globulin nephropathy. Since there is no other data available, classification is not possible. In addition, for a related compound, sodium bromate, kidney is selected as the target organ since "kidney syndrome and kidney tubule hypertrophy were observed in kidney" (NTP DB (Access on December 2008)) in the 27-week and 43-week study of administration in drinking water to male and female mice.	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available	FY2008	GHS Classification Guidance by the Japanese Government （Sep, 2008）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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