Item | Information |
---|---|
CAS RN | 7758-89-6 |
Chemical Name | Cuprous chloride |
Substance ID | m-nite-7758-89-6_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (GESTIS (Access on September 2014)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility: 47 mg/L (20 deg C) (SIDS (2006)) were obtained, it is estimated that it does not react vigorously with water. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Not classified |
- |
- | - | It is an inorganic compound containing halogen (but not oxygen), but the chlorine ion from the chloride does not contribute to oxidization. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a report of an LD50 value of 140 mg/kg for rats (GESTIS (Access on September 2014)). However, since it is information in List 3, and it was not possible to confirm the original source, it was classified as "Classification not possible." The information source was changed, and the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | There are 2 reports of LD50 values of >2,000 mg/kg (male) and >1,224 mg/kg (female) for rats (SIDS (2006)). They corresponded to "Not classified" or "Classification not possible," respectively, therefore, it was classified as "Not classified." A new information source (SIDS (2006)) was added, and the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Since no data for evidence in the previous classification was registered, the category was revised. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that hardness and crust on the application site were observed in an acute toxicity test (OECD TG 402) in which this substance was dermally applied for 24 hours (SIDS (2006)), therefore, it may be irritating to the skin. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there is a description that copper compounds cause conjunctivitis, ulceration and turbidity of the cornea in the eye (ACGIH (7th, 2001)). However, the data was judged insufficient for use in the classification since specific information such as substance information was unknown. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There are neither reports of test results in experimental animals nor epidemiological studies regarding skin sensitization. However, Japan Society For Occupational Health (JSOH) designated copper as occupational skin sensitizers Group 2 (although it indicates the substance itself or its compound, the evaluation does not necessarily apply to all individual chemicals within the group), therefore, it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a mouse bone marrow micronucleus test (SIDS (2006)). As for in vitro, it was negative in a bacterial reverse mutation test, and it was positive in a chromosomal aberration test with cultured mammalian cells (SIDS (2006), DFGOT vol. 22 (2006)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | EPA classified this substance as D (IRIS (Access on October 2014)). From the above, it was classified as "Classification not possible." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. There is a report that in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG 422) with rats by the oral route (gavage), at a dose where parental toxicity (death in 3/12 animals, anemia, squamous cell hyperplasia in the forestomach) was observed, no effects on fertility were observed. However, icterus (3/120 animals, 3/9 maternal animals) and runts (2/120 animals, 2/9 maternal animals) were observed in pups (SIDS (2006)). However, maternal toxicity was pronounced, therefore, it was not adopted as evidence for classification. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Since there were no data on this substance, it was classified as "Classification not possible." Besides, it was reported that by the inhalation exposure to copper dusts and mists in humans, irritation of the respiratory tract, coughing, nausea, headache, gastric pain, vomiting, hemorrhagic gastritis, diarrhea and symptoms similar to metal fume fever were observed. In addition, there is a description of gastrointestinal tract irritation, nausea, vomiting and diarrhea by the oral ingestion of metal copper in humans (ACGIH (7th, 2001), DFGOT vol. 22 (2006)). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood system) |
Warning |
H373 | P260 P314 P501 |
There is no hazardous knowledge by exposure to this substance in humans. In a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test in which rats were given this substance orally (gavage), squamous cell hyperplasia of the forestomach was observed at a dose (5 mg/kg/day (converted guidance value: equivalent to about 1.7 mg/kg/day)) corresponding to Category 1 and hematotoxicity effects (decreases in red blood cell count, hemoglobin concentration and hematocrit, increases in white blood cell count, neutrophil ratio and platelet count, bone marrow hyperplasia of the femur) were observed at a dose (80 mg/kg/day (converted guidance value: equivalent to about 26.7 mg/kg/day)) corresponding to Category 2 (SIDS (2006)). Since it was considered that the former is due to the irritating effect on the mucosa from copper and was not included in relevant findings to determine target organs, it was classified in Category 2 (blood system). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 96-hour LC50 = 0.018 mg/L for fish (Oncorhynchus mykiss) (ECETOC TR91, 2003). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 72-hour NOEC = 0.038 mg/L for algae (Pseudokirchneriella subcapitata) (SIDS, 2011). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 96-hour LC50 = 0.018 mg/L for fish (Oncorhynchus mykiss) (ECETOC TR91, 2003). From the above results, it was classified in Category 1. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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