Item | Information |
---|---|
CAS RN | 7761-88-8 |
Chemical Name | Nitric acid silver(I) |
Substance ID | m-nite-7761-88-8_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | It is a nitrate, containing a chemical group associated with explosive properties. However, it is classified in Division 5.1, PG II (UN1493) in UNRTDG, not applicable to the hazards of the highest precedence, explosives. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (1998)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | It is a nitrate, containing a chemical group associated with explosive properties, but it was classified as oxidizing solids. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (1998)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (1998)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | Because data of water solubility: 2,160 g/L (20 deg C) (GESTIS (Access on September 2014)) were obtained, it is estimated that it does not react vigorously with water. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Category 2 |
Danger |
H272 | P370+P378 P210 P220 P280 P501 |
Because it is classified in Division 5.1, PG II (UN1493) in UNRTDG, it was classified in Category 2. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on a report of an LD50 value of 1,170 mg/kg for rats (IUCLID (2000)), it was classified in Category 4. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
There is a description that this substance caused corrosivity to the skin (CICAD 44 (2003)). In addition, there is a report of chemical burns by contact with this substance in occupational exposure (ATSDR (1990)). From the above results, it was classified in Category 1. Moreover, this substance was classified as "C; R34" in the EU DSD classification, and as "Skin Corr. 1B H314" in the EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
There is a description that this substance caused severe corrosivity to the eyes (CICAD 44 (2003)). In addition, there is a report of chemical burns by contact with the eyes in occupational exposure (ATSDR (1990)). Additionally, this substance was classified in Category 1 for skin corrosion/irritation. From the above results, it was classified in Category 1. Moreover, this substance was classified as "C; R34" in the EU DSD classification, and as "Skin Corr. 1B H314" in the EU CLP classification. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, there are reports that in a test with pregnant monkeys administered by intrauterine injection, although vaginal bleeding and abortion were observed, the animals delivered normal offspring after subsequent remating (PATTY (6th, 2012), ACGIH (7th, 2001), ATSDR (1990)). Because this was not conducted by the general human exposure route, it was not used for classification. From the above, it was classified as "Classification not possible" due to lack of data. Besides, in the previous classification, it was classified in Category 2 on the basis that effects on the testis (necrosis of the seminiferous tubules, etc.) were observed by direct administration to the testis. However, it is described in IUCLID (2000) that this test was unreliable because it was not conducted either by general protocol or by the normal administration route, and because effects were not well documented. In addition, since there were only effects on the testis and reproductive effects were unknown, the classification was changed from Category 2 to "Classification not possible." |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
This substance was corrosive and irritating to the respiratory tract (ATSDR (1990), PATTY (6th, 2012)). In humans, there is a report of irritation to the respiratory tract mucosa by inhalation exposure to the dust and burning sensation and pain in the mouth, salivation, vomiting, abdominal pain, diarrhea, severe gastroenteritis, hypotension, reduced breathing rate, vertigo, convulsions, paralysis of the diaphragm muscle, coma, central nervous system disorder and death as oral acute poisoning symptoms (HSDB (Access on September 2014)). There were no data in experimental animals. From the above, although there is a description showing effects on the central nervous system, it is only in HSDB, the information source of List 2, and the original source could not be confirmed, therefore, the central nervous system was not adopted. Additionally, in the previous classification, although the effects on the blood system from methemoglobinemia and cyanosis in experimental animals (Category 1 (hemal system)) were adopted using the information sources in List 3, the blood system was not adopted because no description showing effects on the blood system was found in List 1 and List 2 in humans and experimental animals, and original source could not be confirmed from information sources in List 3 shown in the previous classification. Therefore, this substance was considered to be irritating to the respiratory tract, and it was classified in Category 3 (respiratory tract irritation). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory organs) |
Danger |
H372 | P260 P264 P270 P314 P501 |
There is a description that 25 out of 30 workers exposed to silver dust for less than 1 year to more than 10 years at a plant manufacturing silver nitrate and silver oxide complained of upper respiratory irritation symptoms (sneezing, running nose, nasal stuffiness, sore throat), and 10 of the 30 workers complained of abdominal pain (burning pain relieved by antacids) (ATSDR (1990), ACGIH (7th, 2001)). Of these, abdominal pain may be due to the effects of mucous membrane irritation by the oral ingestion of part of the dust, it was considered that it should not be adopted as the target organ because it was observed in a few workers (1/3 of the total), and other gastrointestinal symptoms such as diarrhea and vomiting were not described. On the other hand, as for experimental animals, in a test in which rats were given this substance in drinking water at 222 mg Ag/kg/day (equivalent to 349.6 mg/kg/day) for 37 weeks, although increased mortality was observed after 23 weeks, there are no description of organs toxicity except for ocular argyria (ACGIH (7th, 2001)). In addition, there is a description that in a test in which rats were dosed by drinking water at 89 mg Ag/kg/day (equivalent to 140 mg/kg/day) for 9 months, enlargement of the left ventricle was observed (ATSDR (1990), ACGIH (7th, 2001)). However, there was no report of effects on the cardiovascular system in humans or other animal tests, and this result was considered to be unreliable (ATSDR (1990)). There were no other available data for classification in experimental animals. From the above, it was classified in Category 1 (respiratory organs). Besides, although in the previous classification, "kidney" and "cardiovascular system" were adopted as target organs based on the data from the information source in List 3, "cardiovascular system" was deleted for the reason described above. As for kidney, although there was a concern about adverse effects on kidney function due to deposition of silver in the kidneys, there was no evidence in tests with experimental animals, and there were also no data which correlated the amount of silver exposure with renal dysfunction in humans in the findings in occupational exposure. Considering a description that the evidence of "kidney" as the target organ was insufficient (ATSDR (1990)), "kidney" was deleted from the target organ. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
It was classified in Category 1 from 48-hour EC50 = 0.0014 mg/L (0.0009 mgAg/L) for crustacea (Daphnia magna) (CICADs 44, 2002). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 60-day LOEC = 0.00016 mg/L for fish (Oncorhynchus mykiss) (CICADs 44, 2002). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 due to unknown environmental dynamics of the inorganic compound, and 48-hour EC50 = 0.0014 mg/L (0.0009 mgAg/L) for crustacea (Daphnia magna) (CICADs 44, 2002). From the above results, it was classified in Category 1. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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