NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7773-01-5
Chemical Name	Manganese(II) chloride
Substance ID	m-nite-7773-01-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains metals (Mn), but it is estimated that it does not react vigorously with water from the measurement data of water solubility of 723 g/L (25 deg C) (GESTIS (Access on September 2017)).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing chlorine, but the classification is not possible due to no data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on reports of LD50 values of 331 mg/kg (female), 342 mg/kg (male), 351 mg/kg (male), 412 mg/kg (male), 642 mg/kg (male) for rats (all of the data from ATSDR (2012)), this substance was classified in Category 4.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data. Although it is not the information on this substance, manganese salts are reported to be negative in the LLNA test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), but the details are unknown.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Category 2	Warning	H341	P308+P313 P201 P202 P280 P405 P501	As for in vivo, this substance was positive in a micronucleus test with rat bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)), and the tetrahydrate of this substance (MnCl2 4H2O, CAS RN 13446-34-9) was negative in chromosome aberration tests with rat spermatogonial cells and bone marrow cells (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), ATSDR (2012), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)). As for in vitro, this substance was positive in all of bacterial reverse mutation tests, a mammalian cell mouse lymphoma test and a chromosome aberration test (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999), ATSDR (2012), Risk Assessment Report (Beverages) (Food Safety Commission of Japan, 2012)). From the above, this substance was classified in Category 2 according to the GHS classification guidance for the Japanese Government.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	There is no data on this substance itself, but it was considered that the classification result of manganese chloride tetrahydrate (CAS RN 13446-34-9) which is a soluble manganese compound can be used. In the classification of manganese chloride tetrahydrate, it was classified as "Classification not possible" due to lack of data based on the following NTP's conclusion and no classification results for manganese compounds by other organizations (GHS classification results by the Japanese Government in FY2016); NTP concluded that there was no evidence of carcinogenicity in rats of both sexes in carcinogenicity tests with rats and mice given by feeding manganese sulfate monohydrate, a soluble divalent manganese compound, however, that there was equivocal evidence of carcinogenicity in mice, both sexes of which showed a slight increase in thyroid follicular cell adenoma. Therefore, this substance which is the anhydrate was also classified as "Classification not possible" in the same way.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B	Danger	H360	P308+P313 P201 P202 P280 P405 P501	There is no information on the reproductive effects in humans. As for experimental animals, dose-dependent teratogenesis (details unknown) was observed when this substance was given by gavage to pregnant rats throughout the gestation period, but no abnormality was observed by the administration in the organogenesis stage (CICAD 12 (1999)). In addition, in two tests in which this substance was intravenously administered to pregnant rats in the organogenesis stage and in a test in which manganese chloride tetrahydrate was administered subcutaneously to mice, increased frequency of skeletal abnormalities (skeleton of the whole body) was observed at or below the doses where maternal toxicity was manifested (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), CICAD 12 (1999)). Furthermore, in a test in which this substance was subcutaneously administered to mice on gestational day 6-18 at up to 2 mg/kg/day, at 2 mg/kg/day where there was no effect on the body weight of maternal animals, the survival rate of offspring was significantly decreased at postnatal day 4 and extension of time in eye opening and testicular descent was observed (OEL Documentations (Japan Society For Occupational Health (JSOH))). As for classifications by other organizations, Japan Society For Occupational Health (JSOH) classified manganese and manganese compounds in the reproductive toxicants Group 2 (OEL Documentations (2014)). As the above, on the basis that in experimental animals, although in tests of the injection route, increased frequency of skeletal abnormalities in the fetuses and decreased survival rates in the newborns were generally observed at or below the doses where the maternal toxicity manifested, and based on the classification result of Japan Society For Occupational Health (JSOH), this substance was classified in Category 1B.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system, respiratory organs)	Danger	H372	P260 P264 P270 P314 P501	Although it is not the information on this substance, when humans are exposed to excess amounts of manganese by the oral or inhalation route, memory disorders, psychiatric symptoms, etc. were observed as acute effects, and as chronic effects, symptoms of manganese addiction similar to those of Parkinson's disease were seen, such as gait disturbance and speech disorders. Serious effects were observed especially in inhalation exposure (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). As for the oral route, in cases of drinking well water containing high concentrations of manganese, and in epidemiological studies on residents living in regions with high manganese concentration, symptoms similar to manganese addiction such as mask-like faces, muscle rigidity, tremors and psychiatric disorders were reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). The influence on the neurobehavioral function by exposure to the dust of manganese dioxide, trimanganese tetraoxide, and manganese salts (sulfate, carbonate, nitrate) in plants manufacturing manganese oxides and manganese salts was reported (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). It is reported that neurotoxicity from manganese addiction due to occupational exposure to manganese dioxide was reported, and that in addition to decreases in visual simple reaction time and in eye-hand coordination, rigidity of the hands was observed (SIDS (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008), ATSDR (2012)). Furthermore, many case reports revealed that manganese compounds, mainly manganese dioxide, produce respiratory disorders (cough, bronchitis, pneumonia, etc.) (ATSDR (2012)). As for experimental animals, there is no information on this substance, but there is information on manganese chloride tetrahydrate (MnCl2 4H2O, CAS RN 13446-34-9, molecular weight 197.91). It is reported that in a 60-day repeated toxicity test with juvenile rats of 3 weeks old dosed by gavage, at 0.31 mg/kg/day corresponding to Category 1 (a converted value equivalent to this substance: 0.971 mg/kg/day, converted guidance value: 0.13 mg/kg/day), increased brain monoamine oxidase activity and neurodegeneration in the cerebral and cerebellar cortex and caudate nucleus were observed (ATSDR (2012), Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). In addition, in a 22-week toxicity test with rats dosed by drinking water, at 6.5 mg/kg/day (a converted value equivalent to this substance: 4.1 mg/kg/day), which is equivalent to Category 1, decreases in spatial memory capacity, open field locomotor activity and acoustic startle response, and increased latency of sensory evoked potentials were reported (ATSDR (2012)). Therefore, this substance was classified in Category 1 (nervous system, respiratory organs).	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour EC50 = 4.6 mg/L [converted value 2.0 mg Mn/L] for crustacea (Daphnia magna) (WHO CICAD:2008), it was classified in Category 2.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 3	- -	H412	P273 P501	If chronic toxicity data are used, then it is classified as "Not classified" because metals are regarded to be non-biodegradable as elements although the behavior of a metal salt in water is unknown, and due to water solubility of 436,000 mg/L, 62-day NOEC (growth) = 6.4 mg/L [converted value 2.78 mg Mn/L] for fish (Salmo trutta) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)), and 21-day NOEC (reproduction inhibition) = 11.9 mg/L [converted value 5.2 mg Mn/L] for crustacea (Daphnia magna) (Initial Risk Assessment (NITE, CERI, NEDO, 2008)). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 3 because metals are regarded to be non-biodegradable as elements although the behavior of a metal salt in water is unknown, and due to water solubility of 436,000 mg/L, and 24 to72-hour EC50 (rate method) = 11.1 mg/L for algae (Asterionella japonica) (Environmental Risk Assessment for Chemical Substances vol. 6 (Ministry of the Environment, 2008)). From the above results, it was classified in Category 3.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2017	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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