Item | Information |
---|---|
CAS RN | 7775-27-1 |
Chemical Name | Disodium peroxydisulfate / Sodium peroxodisulfate |
Substance ID | m-nite-7775-27-1_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified |
- |
- | - | There is a chemical group associated with explosive properties (neighboring oxygen atoms) present in the molecule. However, because it is classified in Division 5.1, PG III (UN1505) in UNRTDG, it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified |
- |
- | - | It is not combustible (ICSC (2002)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | It was classified in oxidizing solids. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It is not combustible (ICSC (2002)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It is not combustible (ICSC (2002)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Not applicable) |
- |
- | - | The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Category 3 |
Warning |
H272 | P370+P378 P210 P220 P280 P501 |
It is classified in Division 5.1, PG III (UN1505) in UNRTDG. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic compound. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | No data available. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
Based on reports of LD50 values of 895 mg/kg (male), 920 mg/kg (female), and 930 mg/kg (male) for rats (SIDS (2006), NICNAS (2001)), it was classified in Category 4. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | Based on a report of an LD50 value of >10,000 mg/kg for rabbits (SIDS (2006), NICNAS (2001)), it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified |
- |
- | - | Based on reports of LC50 values (4 hours) of >5.1 mg/L (SIDS (2006), NICNAS (2001)) and >21.6 mg/L (NICNAS (2001)) for rats, it was classified as "Not classified." Besides, the reference values for the dust were used based on the fact that this substance is a solid, there were no vapour pressure data and a description that the test was conducted with the dust. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Not classified |
- |
- | - | In a skin irritation test in which this substance was applied to rabbits for 4 hours, the average scores for erythema and edema were 0, and it was judged to be not irritating (SIDS (2006)). In addition, in other studies with rabbits, the results were also not irritating or very slightly irritating (SIDS (2006), NICNAS (2001)). From the above results, by deleting the information sources in List 3, and adding the ones in List 1, the category was changed according to the revision of the GHS classification guidance for the Japanese Government. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Not classified |
- |
- | - | In an eye irritation test with rabbits, the average scores for iritis, keratitis and conjunctivitis were all 0, and it was judged as not irritating (SIDS (2006)). In addition, although there is a description that in another test with rabbits, slight conjunctivitis was observed 48 hours after application (NICNAS (2001)), it was judged as not irritating in IUCLID (2000) which was a reference source of this description. From the above results, it was classified as "Not classified." | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Category 1 |
Danger |
H334 | P304+P340 P342+P311 P261 P284 P501 |
There are case reports that asthma symptoms were induced by inhalation exposure in humans (SIDS (2006), NICNAS (2001)). Since it was concluded in SIDS (2006) and NICNAS (2001) that this substance was positive in respiratory sensitization, it was classified in Category 1. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Category 1 |
Warning |
H317 | P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501 |
There are two sensitization tests with guinea pigs (OECD TG 406, GLP-compliant). In one study, only slight erythema was observed (1/20 animals in the treatment group, 3/20 animals in the control group), therefore, it was judged as non-sensitizing (SIDS (2006)). In the other test, after induction, positive results were obtained for the challenge by intradermal injection, and negative results were obtained for the challenge by epidermal application (SIDS (2006), NICNAS (2001)). In humans, there are both results in patch tests indicating non-sensitizing (SIDS (2006)) and sensitizing (NICNAS (2001)). From these reports, it was determined in SIDS (2006) and NICNAS (2001) that this substance was a sensitizer. From the above results, although there were both negative and positive results, the positive results were obtained in humans and animals, and it was also concluded that it is sensitizing in assessment reports in other countries. Therefore, it was classified in Category 1. |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test with mice and an unscheduled DNA synthesis test with rats (IUCLID (2000), NICNAS (2001)). As for in vitro, it was negative in a bacterial reverse mutation test, mammalian cell chromosome aberration test, and an unscheduled DNA synthesis test with cultured hepatocytes of rats (SIDS (2006), IUCLID (2000), NICNAS (2001)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Category 2 (systemic), Category 3 (respiratory tract irritation) |
Warning |
H371 H335 |
P308+P311 P260 P264 P270 P405 P501 P304+P340 P403+P233 P261 P271 P312 |
This substance was irritating to the respiratory tract. There were multiple cases in humans, but no data were available for classification. As for experimental animals, dyspnea, respiratory distress, and nasal discharge by inhalation exposure with rats, and nasal discharge, irregular breathing, sedation, ataxia, dyspnea, diarrhoea, muscular hypotonia and mydriasis by oral administration to rats were reported (SIDS (2006), ACGIH (7th, 2001), NICNAS (2001)). Besides, the findings by oral administration to rats were observed within the concentration range corresponding to Category 2. Based on these findings, it was considered to be irritating to the respiratory tract by inhalation, and by the oral route, effects on multiple organs were observed, however, effects on specific organs were not confirmed. From the above, it was classified in Category 2 (systemic toxicity), in addition, Category 3 (respiratory tract irritation). |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | There were no adverse findings by repeated exposure to this substance with humans. As for experimental animals, in a study in which rats were administered by feeding for 90 days, no toxic findings were observed within or lower than the dose range for Category 2 (1,000 ppm: equivalent to 100 mg/kg/day), and even at a dose exceeding Category 2 (3,000 ppm: equivalent to 225 mg/kg/day), only changes in the gastrointestinal tract epithelial lining (necrosis, atrophy) considered to be due to irritation were observed (SIDS (2006), ACGIH (2001), NICNAS (2001)). Therefore, although it was considered to be equivalent to "Not classified" by the oral route, there was no toxic information in other routes, and it was classified as "Classification not possible" due to lack of data. Besides, in the previous classification, it was classified as "Not classified" only by the oral route information. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Not classified |
- |
- | - | It was classified as "Not classified" from 72-hour ErC50 >1000 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)), 48-hour EC50 = 133 mg/L for crustacea (Daphnia magna) (SIDS, 2005), and 96-hour LC50 >100 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)). | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | If chronic toxicity data are used, then it is classified as "Not classified" from 72-hour NOEC = 3.2 mg/L for algae (Pseudokirchneriella subcapitata) (Results of Aquatic Toxicity Tests of Chemicals conducted by Environment Agency in Japan (Environment Agency, 1999)) although environmental dynamics of the inorganic compound are unknown. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" because it corresponds to "Not classified" in acute toxicity for fish and is not water-insoluble (water solubility = 549 g/L (NITE, 2014)). From the above results, it was classified as "Not classified." |
FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2014 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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