Item | Information |
---|---|
CAS RN | 7778-54-3 |
Chemical Name | Calcium hypochlorite |
Substance ID | m-nite-7778-54-3_v2 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Flammable solids | Not classified |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on August 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on August 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | It was classified as "Not classified" from information that it is not combustible (GESTIS (Access on August 2020)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | It contains a metal (Ca), but it was classified as "Not classified" because it is estimated that it does not react vigorously with water from water solubility data of about 214 g/L (20 deg C) (SIAR (2006)). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition). It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
14 | Oxidizing solids | Category 2 |
Danger |
H272 | P370+P378 P210 P220 P280 P501 |
It was classified in Category 2 because it is classified in Division 5.1, PG II in UNRTDG (UN1748). | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | Inorganic compound. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Classification is not possible because test methods applicable to solid substances are not available. | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
17 | Desensitized explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. It was classified as "Not classified." | FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
[Rationale for the Classification] It was classified in Category 4 from (1). [Evidence Data] (1) LD50 for rats: males: 790 mg/kg (AICIS (formerly, NICNAS) IMAP (2015), SIAP (2006), SIAR (2006), GESTIS (Access on August 2020), HSDB (Access on August 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Dermal) | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1). [Evidence Data] (1) LD50 for rabbits: > 2,000 mg/kg (SIAR (2006), HSDB (Access on August 2020)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified |
- |
- | - | [Rationale for the Classification] Solid (GHS definition). It was classified as "Not classified." |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 2 |
Danger |
H330 | P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501 |
[Rationale for the Classification] It was classified in Category 2 from (1). Besides, the classification result was changed from the previous classification by using new information sources. Because an exposure concentration was higher than the saturated vapor pressure concentration (3.9E-010 mg/L), a reference value in the unit of mg/L was applied as dust. [Evidence Data] (1) LC50 for rats (1 hour): 1.202-1.423 mg/L (converted 4-hour equivalent value: 0.301-0.356 mg/L) (SIAR (2006)) (2) Vapor pressure of this substance: 5.03E-011 mmHg (25 deg C) (est) (U.S.EPA: Mpbpwin v1.43) (converted value for the saturated vapor pressure concentration: 3.9E-010 mg/L) [Reference Data, etc.] (3) LC50 for rats (1 hour) on the product (containing 32% of this substance): > 176.4 mg/L (converted 4-hour equivalent value: > 44.1 mg/L (100% converted value: > 14.1 mg/L)) (Agchem Age No. 162 (Japan Crop Protection Association, 1991)) (4) LC50 for rats (3 hours) on the product (containing 32% of this substance): > 158.3 mg/L (converted 4-hour equivalent value: > 118.7 mg/L (100% converted value: > 38.0 mg/L)) (Agchem Age No. 162 (Japan Crop Protection Association, 1991)) |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
2 | Skin corrosion/irritation | Category 1 |
Danger |
H314 | P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501 |
[Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) This substance is corrosive to the skin due to the alkalinity of the hypochlorite ion (AICIS (formerly, NICNAS) IMAP (2015)). (2) Direct contact with this substance can be irritating or corrosive (SIAP (2006), GESTIS (Access on August 2020)). [Reference Data, etc.] (3) This substance is often quoted as "corrosive to the skin." The source of this statement was, however, not retrievable, and no additional information was available to substantiate it. Severe effects on the eyes can be expected due to the alkalinity of the calcium cation and non-reacted calcium hydroxide (pH = 12.0 at 1%) (SIAR (2006)). (4) It was classified in Skin Corr. 1B (H314) in EU-CLP classification (EU CLP classification (Access on October 2020)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
3 | Serious eye damage/eye irritation | Category 1 |
Danger |
H318 | P305+P351+P338 P280 P310 |
[Rationale for the Classification] It was classified in Category 1 from (1), (2). [Evidence Data] (1) This substance was classified in Category 1 in skin corrosion/irritation. (2) Direct contact with this substance can be irritating or corrosive (SIAP (2006), GESTIS (Access on August 2020)). [Reference Data, etc.] (4) This substance is often quoted as "corrosive to the skin." The source of this statement was, however, not retrievable, and no additional information was available to substantiate it. Severe effects on the eyes can be expected due to the alkalinity of the calcium cation and non-reacted calcium hydroxide (pH = 12.0 at 1%) (SIAR (2006)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | [Rationale for the Classification] There was a description of (1), but it was classified as "Classification not possible" due to lack of data. The classification result was changed because new information (1) conflicted with the rationale data for the previous classification. [Reference Data, etc.] (1) Repeated insult patch tests conducted on healthy human volunteers have shown no evidence of potential allergic contact dermatitis (AICIS (formerly, NICNAS) IMAP (2015)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
5 | Germ cell mutagenicity | Not classified |
- |
- | - | [Rationale for the Classification] It was classified as "Not classified" from (1) - (3). [Evidence Data] (1) As for in vivo, sodium hypochlorite was reported to be negative in micronucleus tests using the bone marrow after intraperitoneal or oral administration to mice and negative in a chromosomal aberration test using the bone marrow after oral administration to mice (SIAR (2006)). (2) As for in vitro, this substance was reported to be negative in a bacterial reverse mutation test and positive in a chromosomal aberration test with cultured mammalian cells (SIAR (2006)). (3) It is described in AICIS that both sodium hypochlorite and calcium hypochlorite (this substance) were considered to have no genotoxic potential (AICIS (formerly, NICNAS) IMAP (2015)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
6 | Carcinogenicity | Not classified |
- |
- | - | [Rationale for the Classification] Although no classification results by domestic and international organizations or carcinogenicity reports were obtained for this substance, it was classified as "Not classified" from classification results by other organizations for hypochlorite salts in (1) and carcinogenicity test results in experimental animals for sodium hypochlorite in (2) and (3). [Evidence Data] (1) As for classification results by domestic and international organizations, IARC classified hypochlorite salts, including this substance, in Group 3 (IARC 52 (1991)). (2) In a 104-week drinking water administration test in rats and a 103-week drinking water administration test in mice both using sodium hypochlorite (CAS RN 7681-52-9), no significant increase in tumor incidences was observed (IARC 52 (1991)). (3) In a carcinogenicity test with mice using sodium hypochlorite in the dermal route, no carcinogenicity was seen (IARC 52 (1991)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | [Rationale for the Classification] There was no information on this substance, however, since this substance dissociated into hypochlorite ions and calcium ions in aqueous solution from (1), the classification was made based on the information on sodium hypochlorite (CAS RN 7790-92-3). Based on (2) to (4), it could be generally considered to have no reproductive effects, but since there were no data on developmental toxicity when administeredonly during the organogenesis period, it was determined that classification was not possible due to lack of data. [Evidence Data] (1) This substance dissociated into hypochlorite ions and calcium ions in aqueous solution (SIAR (2006)). (2) In a one-generation reproduction toxicity study by oral administration of hypochlorous acid to rats dosed by gavage, there were no clinical signs of toxicity, hematological changes, body weight depression, alterations in sperm count, sperm motility, or sperm morphology, or histopathological lesions in the reproductive organs, and there were no dose-related effects on fertility, fetal viability, litter size, fetal body weight, day of eye opening, or day of vaginal patency (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (3) In a test by oral administration of hypochlorous acid to female rats dosed by drinking water from 2.5 months before mating through the gestation period, no maternal toxicity or developmental toxicity was observed (EURAR (2007), AICIS (previous NICNAS) IMAP (2014)). (4) In the EURAR (2007), there were no data on sodium hypochlorite (CAS RN 7681-52-9). However, it was reported that, although the data available were limited, the results of the animal studies using hypochlorous acid and chlorine could draw the conclusion that there was no evidence to suggest that sodium hypochlorite would present adverse effects on development of the next generation or fertility. It was stated that, similarly, no such evidence was obtained from epidemiological studies on populations consuming chlorinated drinking water (EURAR (2007)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation) |
Warning |
H335 | P304+P340 P403+P233 P261 P271 P312 P405 P501 |
[Rationale for the Classification] Based on (1) to (3), it was classified in Category 3 (respiratory tract irritation). The data on the central nervous system in (4) were not adopted because specific symptoms were unknown. Based on the review of the information and the use of a new information source, the classification result was changed from the previous classification. [Evidence Data] (1) The ingestion of this substance by a worker in the form of tablets (dose not known) caused vomiting and respiratory complaints (GESTIS (Access on August 2020)). (2) This substance was irritating to the nose and eye (HSDB (Access on August 2020)). (3) The inhalation of a mist of this substance was expected to cause moderate to strong irritation in the nose, throat, and upper airways (GESTIS (Access on August 2020)). [Reference Data, etc.] (4) In an acute oral toxicity test with male rats, moderate depression of the central nervous system one hour after administration, mild to moderate persistent anorexia, and diarrhea were observed at 890-1,260 mg/kg (within the range for Category 2) (AICIS (previous NICNAS) IMAP (2015), SIAR (2006)). (5) This substance dissociated into hypochlorite ions and calcium ions in aqueous solution. Human health effect might be caused by contact with the solid powder, the aqueous solution, or accidentally generated chlorine gas. As for hypochlorite ion toxicity, the exposure scenario for this substance was the same as for sodium hypochlorite solution or chlorine gas, which was utilized as a source of hypochlorite ions (SIAR (2006)). (6) This substance released highly concentrated chlorine gas when it was mixed with strong acids (AICIS (previous NICNAS) IMAP (2015)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | [Rationale for the Classification] There was no information on this substance itself, but the classification was made based on the information on sodium hypochlorite (CAS RN 7681-52-9) from (1). Based on (2) and (3), it was considered that repeated dose toxicity of sodium hypochlorite in the oral and dermal routes was low, but since effects on the respiratory organs due to inhalation exposure were unknown, it was determined that classification was not possible. [Reference Data, etc.] (1) This substance dissociated into hypochlorite ions and calcium ions in aqueous solution (SIAR (2006)). (2) In tests by oral administration of sodium hypochlorite to animals dosed by drinking water, only reduced body weight gain, presumably due to low water intake, was observed when rats and mice were dosed for 90 days and 2 years (SIAR (2006)). (3) In a test by dermal application of an aqueous solution of sodium hypochlorite to guinea pigs for 51 weeks (twice a week), no treatment-related effects were observed (AICIS (previous NICNAS) IMAP (2015), EURAR (2007), SIAR (2006)). |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | [Rationale for the Classification] Classification not possible due to lack of data. |
FY2020 | GHS Classification Guidance for the Japanese Government (FY2019 revised edition (Ver. 2.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 1 |
Warning |
H400 | P273 P391 P501 |
From 48-hour LC50 = 0.005-0.006 mg/L for crustacea (Ceriodaphnia dubia) (SIDS, 2006), it was classified in Category 1. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Category 1 |
Warning |
H410 | P273 P391 P501 |
If chronic toxicity data are used, then it is classified in Category 1 because this substance is an inorganic compound, and appropriate data on rapid degradability were not obtained, and due to 133-day NOEC = 0.005 mg/L for fish (Lepomis macrochirus) (SIDS, 2006). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 because this substance is an inorganic compound, and appropriate data on rapid degradability were not obtained, and due to 48-hour LC50 = 0.005-0.006 mg/L or crustacea (Ceriodaphnia dubia) (SIDS, 2006). From the above results, it was classified in Category 1. |
FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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