NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7779-90-0
Chemical Name	Zinc phosphate
Substance ID	m-nite-7779-90-0_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecule.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is not combustible (GESTIS (Accessed Aug. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is not combustible (GESTIS (Accessed Aug. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is not combustible (GESTIS (Accessed Aug. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It contains a metal (Zn). However, because there is an observation result that it is insoluble in water (GESTIS (Accessed Aug. 2018)), it is estimated that it does not react vigorously with water.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound containing oxygen, but the classification is not possible due to no data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) LD50 for rats: > 5,000 mg/kg (EU-RAR (2008))	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	[Rationale for the Classification] Solid (GHS definition)	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) There is a report that zinc oxide, an analogue, is not irritating to the skin (EU-RAR (2008)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Not classified	- -	-	-	[Rationale for the Classification] Based on (1), it was classified as "Not classified." [Evidence Data] (1) There is a report that in an eye irritation test (OECD TG405, GLP-compliant) with rabbits, when this substance was applied, mild conjunctival irritation and conjunctival edema (each score of 1 or less) were observed, but they resolved within 72 hours (EU-RAR (2008), REACH registration dossier (Accessed Aug. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) As for zinc oxide, an analogue, there is a report that in a maximization test (OECD TG406, GLP-compliant) with guinea pigs, skin sensitization was not observed (REACH registration dossier (Accessed Aug. 2018)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data. [Reference Data, etc.] (1) In an assessment from the EU, it is concluded that there is no evidence that zinc is genotoxic in vivo (EU-RAR (2008)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	[Rationale for the Classification] There are no data on this substance itself in either humans or experimental animals. On the other hand, the toxic effects related to the administration of this substance seem to be due to zinc ions after absorption into the body, and the EU conducted the evaluation using data on other zinc compounds (EU-RAR (2008)). So, the reproductive effects of other zinc compounds were also considered in this classification. As for effects on humans, in (1) it is reported that reproductive and developmental effects were not observed. As for experimental animals, in (2)-(4), the possibility of an effect on the genetic organs and an effect on fertility is reported. From the above, based on the results of animal tests for zinc compounds, this substance was classified in Category 2. [Evidence Data] (1) There is a report that no reproductive and developmental effects were observed in pregnant women who ingested orally 0.3 mg Zn2+/kg/day of zinc sulfate or zinc citrate during the last 6 months of gestation (EU-RAR (2008)). However, there is no report of adverse effects on human reproduction due to overdose (EU-RAR (2008)). (2) In a test, in which male rats were dosed by feeding with anhydrous zinc sulfate for 30-32 days before mating, decreased sperm counts were observed at a dose of 200 mg Zn2+/kg/day (EU-RAR (2008)). (3) When female rats were dosed with anhydrous zinc sulfate at a dose of 200 mg Zn2+/kg/day after mating with males, reduced conception was observed (EU-RAR (2008)). (4) There is a report that in a test, in which male and female rats were repeatedly administered zinc monoglycerolate, hypoplasia of seminiferous tubules in males and hypoplasia of the uterus in females were observed at a dose of 300 mg Zn2+/kg/day. Besides, in developmental toxicity tests of zinc sulfate with mice, rats, hamsters, and rabbits, no effects were observed in either maternal animals or fetuses (EU-RAR (2008)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	[Rationale for the Classification] Based on (1), although this substance is corresponding to "Not classified" in the oral route, it was classified as "Classification not possible" due to lack of toxicity information in other routes. [Evidence Data] (1) As a result of single oral exposure to rats, no effect was observed within or lower than the dose range of Category 2 (EU-RAR (2008)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)	Danger	H372	P260 P264 P270 P314 P501	[Rationale for the Classification] As for this substance, there are no available data on either humans or experimental animals for classification. However, on an assessment of the EU, the EU conducted an evaluation using data on other zinc compounds based on the consideration that biological activities after intake of zinc compounds are due to zinc ions, (EU-RAR (2008)). Therefore, also in this hazard class, it was determined to consider repeated exposure effects of other zinc compounds. Based on (1) and (2), though it is described that anemia does not occur in daily life in humans, the possibility of anemia as an effect on the hemal system due to long-term exposure cannot be excluded. Therefore, it was classified in Category 1 (hemal system). [Evidence Data] (1) There is a report that in humans who ingested zinc supplement, at 150 mg Zn2+/day (2.5 mg Zn2+/kg/day, a converted value equivalent to this substance: 14.8 mg/kg/day), headache, nausea, gastric discomfort, disturbance of copper homeostasis (a decrease in serum ceruloplasmin activity, a decrease in erythrocyte SOD activity, a decrease in platelet cytochrome c oxidase) occur (EU-RAR (2008), SIDS SIAP (2005)). (2) As for humans, there is a report of cases of anemia due to copper deficiency following zinc overdose. However, in the case report of long-term intake of zinc for treatment purposes, it is reported that erythrocyte dysfunction due to zinc overdose doesn't occur in the usual dietary life (Initial Risk Assessment Report (NITE, CERI, NEDO, 2008)). [Reference Data, etc.] (3) It is reported that in a 13-week oral administration test with rats and mice (zinc sulfate heptahydrate, zinc monoglycerolate), no toxic findings were observed within the dose range up to Category 2 (100 mg this substance/kg/day) as a converted value equivalent to this substance, and that a decreased copper level in the blood and effects on the pancreas and spleen were observed at a dose exceeding the range of Category 2 (EU-RAR (2008)).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	[Rationale for the Classification] Classification not possible due to lack of data.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 1	Warning	H400	P273 P391 P501	It was classified in Category 1 from 48-hour LC50 = 0.08 mg/L [converted value 0.04 mgZn/L] for crustacea (Daphnia pulex) (WHO/IPCS EHC: 2001).	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 1	Warning	H410	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 1 from 72-hour NOEC (cell growth) = 0.06 mg/L [converted value 0.03 mgZn/L] for algae (Pseudokirchneriella subcapitata) (WHO/IPCS EHC: 2001) despite unknown environmental dynamics of the metal compound. If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 1 from 96-hour LC50 = 0.120 mg/L [converted value 0.061 mgZn/L] for fish (Oncorhynchus clarkii) (WHO/IPCS EHC: 2001) despite unknown environmental dynamics of the metal compound. From the above results, it was classified in Category 1.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data available.	FY2018	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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