NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7782-50-5
Chemical Name	Chlorine
Substance ID	m-nite-7782-50-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Flammable gases	Not classified	- -	-	-	Not combustible (HSDB (Access on September 2013))	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Oxidizing gases	Category 1	Danger	H270	P370+P376 P220 P244 P403	This substance is an oxidizing gas listed in ISO 10156-2010. It is classified in Division 2.3 (Subsidiary Risk 5.1,8) (UN1017) in UNRTDG.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	From a critical temperature (144 deg C (HSDB (Access on September 2013))) above +65 deg C, it was classified as liquefied gas (low pressure liquefied gas).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Dermal)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Gases)	Category 2	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	There are reports on 1-hour LC50 values for rats of 293-1,000 ppm (converted 4-hour equivalent value: 147-500 ppm) (PATTY (6th, 2012)), 850 mg/m3 (293 ppm) (converted 4-hour equivalent value: 146 ppm) (EHC 21 (1982), ATSDR (2010), ACGIH (7th, 2001)), and 447 ppm (converted 4-hour equivalent value: 224 ppm) (ATSDR (2010), EU-RAR (2007)). There are reports on a 53-minute exposure LC50 value for rats of 1,000 ppm (converted 4-hour equivalent value: 470 ppm) (ATSDR (2010)), 30-minute exposure LC50 value for rats of 688 ppm (converted 4-hour equivalent value: 243 ppm) (ATSDR (2010)), and a 440-minute exposure LC50 value for rats of 250 ppm (converted 4-hour equivalent value: 339 ppm) (ATSDR (2010)). It was classified in Category 2 because all of these LC50 values corresponded to Category 2.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
2	Skin corrosion/irritation	Category 1	Danger	H314	P301+P330+P331 P303+P361+P353 P305+P351+P338 P304+P340 P260 P264 P280 P310 P321 P363 P405 P501	In humans, there is a case of persons who had mild burns of the face from exposure to chlorine gas (EHC 21 (1982)), and it is described that it can be corrosive to the skin (HSDB (Access on September 2013)). And because it is described that liquefied chlorine causes frostbite and burns (HSDB (Access on September 2013)), special caution is needed for contact with liquefied chlorine. Category 1 is proposed in EU-RAR (2007) because it is corrosive to the skin. Therefore, it was classified in Category 1 based on the above information. Besides, this substance is classified in "Xi; R36/37/38" in EU DSD classification and in "Skin Irrit. 2 H315" in EU CLP classification. EU-RAR, EU DSD classification, and EU CLP classification, obtained in this investigation, were added.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
3	Serious eye damage/eye irritation	Category 1	Danger	H318	P305+P351+P338 P280 P310	It is described that there may be severe effects in the eye from exposure to this substance (details: not described) (SIDS-SIAP (2003)). And it is described that eye irritation was observed in monkeys (PATTY (6th, 2012)), there was slight to severe irritation depending on the concentrations in humans, but this disappeared within a short time (EHC 21 (1982)), and it may be corrosive to the eye, cause burns in the eye in humans, and cause serious or irreversible damage (HSDB (Access on September 2013)). The information in SIDS (2003): severe effects in the eye and the information in HSDB (Access on September 2013): it may be corrosive to the eye, cause burns in the eye in humans, and cause serious or irreversible damage corresponded to Category 1. Besides, this substance is classified in "Xi; R36/37/38" in EU DSD classification and "Eye Irrit. 2 H319" in EU CLP classification. SIDS-SIAP, EU DSD classification, and EU CLP classification, obtained in this investigation, were added.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Respiratory sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
4	Skin sensitization	Classification not possible	- -	-	-	Classification not possible due to lack of data.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. As for in vivo, it was negative in a micronucleus test and a chromosomal aberration test with mouse bone marrow cells (ATSDR (2010), IUCLID (2000)). As for in vitro, there are positive and negative results in bacterial reverse mutation test and chromosomal aberration tests (ATSDR (2010), IUCLID (2000)). Chlorine (sodium hypochlorite) may be mutagenic in vitro, but it is not considered to be mutagenic in vivo (SIDS (2003), EU-RAR (2007)). Besides, tests were often conducted on sodium hypochlorite, and they are regarded to be useful for the assessment of mutagenicity of chlorine (EU-RAR (2007)).	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
6	Carcinogenicity	Classification not possible	- -	-	-	It was classified as "Classification not possible" because it is classified in A4 in ACGIH (1995), Group 3 (as drinking-water disinfected with chlorine) in IARC (1991), and Group D in IRIS (1994). The category was changed according to the revised GHS classification guidance for the Japanese government.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
7	Reproductive toxicity	Not classified	- -	-	-	It was classified as "Not classified" because no effects on fertility of parent animals and development of offspring were observed in tests with rats and mice (EHC 21 (1982), EU-RAR (2007), IRIS (1994), IUCLID (2000)), and it is described that there were no effects on pregnancy through lactation in workers at a chlorine plant (EHC 21 (1982)). EU-RAR (2007) was added.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
8	Specific target organ toxicity - Single exposure	Category 1 (respiratory organs)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	After inhalation exposure in mice, rabbits, and dogs, lesions in the respiratory system such as pulmonary edema, pulmonary hemorrhage, decreased lung function, bronchitis, and necrosis of the epithelium of the trachea were observed at the doses (< 2,500 ppm) equivalent to the guidance value range for Category 1, and the similar lesions were also found in rats, although there are no descriptions of the doses (EHC 21 (1982), EU-RAR (2007)). Furthermore, inflammation of the mucous membranes of the respiratory tract, labored respiration, bradypnea, and irritation of the upper respiratory tract are described in mice, cats, rabbits, and guinea pigs (EHC 21 (1982), ACGIH (7th, 2001), PATTY (6th, 2012), EU-RAR (2007)). In humans, there are descriptions of pneumonia, pulmonary edema, bronchitis, ulcerative tracheo-bronchitis, decreased lung function, asthma and reactive airways dysfunction syndrome (RADS), irritation of the throat and nose, cough, dyspnea, etc. indicating lesions or irritation of the respiratory system (EHC 21 (1982), ACGIH (7th, 2001), PATTY (6th, 2012)). It was classified in Category 1 (respiratory system) based on the above information.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, liver, kidney)	Danger	H372	P260 P264 P270 P314 P501	It is described that in tests in which inhalation exposure to gas was given to rats for 6 weeks and mice for 2 years, lesions in the respiratory tract and lung occurred, or inflammation and histological changes in the epithelium of the respiratory tract were observed at the concentrations (0.41-3 ppm) within the guidance value range for Category 1 (EHC 21 (1982), PATTY (6th, 2012), IUCLID (2000)). In humans, it may cause bronchial disease and pulmonary hemorrhage (EHC 21 (1982)), and findings such as coughing, sore throat, hemoptysis, and chest pain are described (ACGIH (7th, 2001)). It was classified in Category 1 (respiratory system) based on the above information. Furthermore, it was classified in Category 1 (liver, kidney) because it is described that hepatocyte vacuolation (1.4 ppm or above (converted guidance value)) and renal proximal tubular degeneration (4.2 ppm (converted guidance value)) were found at the concentrations within the guidance value range for Category 1 in a 6-week inhalation exposure (gas) test with rats (PATTY (6th, 2012)). Besides, Category 1 (olfactory organ) adopted in the previous classification was removed because the effects concerned were judged to be included in those on the respiratory system. And Category 2 (teeth) in the previous classification was based on the information source in List 3, but it was deleted because no rationale data to adopt the teeth as the target organ could be obtained from the information sources in List 1 and 2 used this time.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Gas (GHS definition)	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	The classification is not possible because appropriate data are not obtained. Besides, this substance forms hydrochloric acid and hypochlorous acid in the water, and hypochlorous acid is known to exert bactericidal effect by its generating hydrogen ion and -ClO of active oxygen species. Therefore, as for the classification in an aquatic environment, it is preferable to refer to the classification for sodium hypochlorite or potassium hypochlorite.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2013	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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