Item | Information |
---|---|
CAS RN | 7782-63-0 |
Chemical Name | Iron(II) sulfate heptahydrate |
Substance ID | m-nite-7782-63-0_v1 |
Download of Excel format | Excel file |
Item | Information |
---|---|
Guidance used for the classification (External link) | To Guidance List |
UN GHS document (External link) | To UN GHS document |
FAQ(GHS classification results by the Japanese Government) | To FAQ |
List of Information Sources (Excel file) | List of Information Sources |
List of Definitions/Abbreviations | Definitions/Abbreviations |
Sample Label by MHLW (External link) | To Workplace Safety Site (MHLW) |
Sample SDS by MHLW (External link) | To Workplace Safety Site (MHLW) |
OECD/eChemPortal (External link) | To OECD/eChemPortal (External link) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Explosives | Not classified (Not applicable) |
- |
- | - | There are no chemical groups associated with explosive properties present in the molecule. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Flammable gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Aerosols | Not classified (Not applicable) |
- |
- | - | Not aerosol products. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Oxidizing gases | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Gases under pressure | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Flammable liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Flammable solids | Not classified |
- |
- | - | Not combustible (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Self-reactive substances and mixtures | Not classified (Not applicable) |
- |
- | - | There are no chemical groups present in the molecule associated with explosive or self-reactive properties. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Pyrophoric liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Pyrophoric solids | Not classified |
- |
- | - | Not combustible (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Self-heating substances and mixtures | Not classified |
- |
- | - | Not combustible (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified |
- |
- | - | From information on water solubility: 29.5 g/100 g (NITE Chemical Risk Information Platform (NITE-CHRIP) (Access on August 2013)), it is recognized that it does not react vigorously with water. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
13 | Oxidizing liquids | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
14 | Oxidizing solids | Classification not possible |
- |
- | - | It is an inorganic compound which does not contain halogen but contains oxygen, however, the classification is not possible due to no data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
15 | Organic peroxides | Not classified (Not applicable) |
- |
- | - | It is an inorganic substance. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
16 | Corrosive to metals | Classification not possible |
- |
- | - | Test methods applicable to solid substances are not available. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
17 | Desensitized explosives | - |
- |
- | - | - | - | - |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 |
Warning |
H302 | P301+P312 P264 P270 P330 P501 |
There are reports on LD50 values for rats of 1,389 mg/kg (EPA Pesticide (1993)) and > 2,000 mg/kg (JECDB (Access on October 2013)) (OECD TG 401). Because there are the same numbers for both Category 4 and "Not classified," it was classified in Category 4 according to the GHS classification guidance for the Japanese government. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Dermal) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Gases) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Vapours) | Not classified (Not applicable) |
- |
- | - | Solid (GHS definition) | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
2 | Skin corrosion/irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, this substance is classified in "Xi; R36/38" in EU DSD classification and "Skin Irrit. 2 H315" in EU CLP classification. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
3 | Serious eye damage/eye irritation | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, this substance is classified in "Xi; R36/38" in EU DSD classification and "Eye Irrit. 2 H319" in EU CLP classification. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Respiratory sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
4 | Skin sensitization | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
5 | Germ cell mutagenicity | Classification not possible |
- |
- | - | It was classified as "Classification not possible" because it was not possible to classify a substance as "Not classified" according to the revised GHS classification guidance for the Japanese government. There is the knowledge that it was negative in an in vivo micronucleus test with the stomach, duodenum, and colon (J. Appl. Toxicol. 8, 179-183, 1988), and a category of iron salts was assessed in SIDS, and the category was evaluated to be not mutagenic in vivo. As for in vitro, it was negative in a bacterial reverse mutation test and positive in a chromosomal aberration test with cultured mammalian cells (JECDB (Access on October 2013)). | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
6 | Carcinogenicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
7 | Reproductive toxicity | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test (OECD TG422) with rats in the oral route (gavage), no fertility effects were observed at the dose (1,000 mg/kg/day) where effects were seen in parent animals. And no effects were found in offspring (JECDB (Access on October 2013)). However, because it is a screening test, and there are no sufficient reports on developmental toxicity, it was classified as "Classification not possible." | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
8 | Specific target organ toxicity - Single exposure | Classification not possible |
- |
- | - | Classification not possible due to lack of data. Besides, it is reported that after gavage administration to rats, a decrease in locomotor activity, salivation, and a transient decrease in body weights were observed at 2,000 mg/kg, the maximum guidance value, but no other toxic signs were found (JECDB (Access on October 2013)). However, there are no reports on the other routes. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible |
- |
- | - | This substance was recognized as GRAS (Generally Recognized As Safe) substance as food additives by the U.S. FDA (EPA Pesticide (1993)). Furthermore, in a combined repeated dose toxicity study with the reproduction/developmental toxicity screening test with rats by gavage administration, increased extramedullary hematopoiesis in the spleen (only in males) was observed at the dose (163 mg/kg/day (converted guidance value)) above the guidance value range for Category 2 (JECDB (Access on Sep. 2013)). From the above, it corresponds to "Not classified" in the oral route. However, because of no toxicity information on the other routes, the classification is not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
10 | Aspiration hazard | Classification not possible |
- |
- | - | Classification not possible due to lack of data. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
Hazard class | Classification | Pictogram Signal word |
Hazard statement (code) |
Precautionary statement (code) |
Rationale for the classification | Classification year (FY) | GHS Classification Guidance for the Japanese Government | |
---|---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment Short term (Acute) | Category 3 |
- |
H402 | P273 P501 |
From 48-hour EC50 = 91 mg/L for crustacea (Daphnia magna) (SIDS, 2008), it was classified in Category 3. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
11 | Hazardous to the aquatic environment Long term (Chronic) | Not classified |
- |
- | - | If chronic toxicity data are used, then it is classified as "Not classified" due to no appropriate data obtained on rapid degradability, and 21-day NOEC = 10 mg/L for crustacea (Daphnia magna) (SIDS, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified as "Not classified" due to 96-hour LC50 > 67 mg/L for fish (Oryzias latipes) (SIDS, 2008) although appropriate data on rapid degradability were not obtained. From the above results, it was classified as "Not classified." |
FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
12 | Hazardous to the ozone layer | Classification not possible |
- |
- | - | This substance is not listed in the Annexes to the Montreal Protocol. | FY2013 | GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0)) |
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