NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7783-96-2
Chemical Name	Silver (I) iodide
Substance ID	m-nite-7783-96-2_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Flammable gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not an aerosol product.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Flammable solids	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	There are no chemical groups present in the molecule associated with explosive or self-reactive properties.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Pyrophoric solids	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Self-heating substances and mixtures	Not classified	- -	-	-	It is non-flammable (GESTIS (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	It is estimated that it does not react vigorously with water from water solubility data measured. Water solubility: 28E-07 g/L (25 degrees C) (HSDB (Access on June 2015)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
14	Oxidizing solids	Classification not possible	- -	-	-	It is an inorganic compound that does not contain oxygen but contains halogen (I), but the classification is not possible due to no data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
16	Corrosive to metals	Classification not possible	- -	-	-	No established test method suitable for solid substances.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	"Solids" according to GHS definition.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Respiratory sensitization	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
4	Skin sensitization	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, Japan Society for Occupational Health classified iodine and its compounds as a skin sensitizer Group 2, but it is written that not all compounds were identified (The Recommendation of Acceptable Concentration of the Japan Society for Occupational Health (2014)).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
5	Germ cell mutagenicity	Classification not possible	- -	-	-	The classification is not possible due to lack of data. Besides, the HSDB information described in the previous classification could not be confirmed.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
6	Carcinogenicity	Classification not possible	- -	-	-	There is no carcinogenicity information on this substance itself. However, as mentioned in specific target organ toxicity (repeated exposure), this substance is absorbed in an inhalation route, and it is thought that its toxicity reflects that of iodine, iodide, and silver compounds. As the classification result for carcinogenicity by other organizations, ACGIH classified iodine and iodide in A4 (ACGIH (7th, 2008)), but the classification in carcinogenicity was not given to silver and its compounds (ACGIH (2015)). Therefore, based on the ACGIH's classification result on iodine and iodide, this substance was classified as "Classification not possible" in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
7	Reproductive toxicity	Category 1B,	Danger	H360 H362	P308+P313 P201 P202 P260 P263 P264 P270 P280 P405 P501	There is no reproductive toxicity information on this substance itself. However, as mentioned in specific target organ toxicity (repeated exposure), this substance is absorbed in an inhalation route, and it is thought that its toxicity reflects that of iodine, iodide, and silver compounds. As the classification of iodide in this hazard class, potassium iodide (CAS number: 7681-11-0) was classified in Category 1B, Additional Category: Effects on or via lactation. However, the rationale data for this classification were based on the information in an oral route in humans as a whole. In the report of Willard, D.H. and Bar, W.J. (1961), the fact was just shown that in gavage administration of Na131I and Ag131I to one sheep each, 131I uptake amount into thyroid was similar (a maximum uptake rate of 131I against dosed amount into thyroid tissue: 56% (after 28 hours) and 48% (after 34 hours) for NaI and AgI respectively), but an absorption experiment of oral dosing Ag131I was not conducted in mice. Therefore, it could not be said that absorption rate of silver iodide in an oral route is as well as that of soluble iodide. However, because it is thought that this substance will be absorbed after inhalation and cause toxicity corresponding to oral administration of potassium iodide as iodide in blood, it was judged that the classification for potassium iodide is applicable to this substance as well. Accordingly, it was classified in Category 1B in this hazard class, and effects on or via lactation were added. Besides, there is the information on reproductive effects of silver compounds that direct injection of silver nitrate into the uterus of pregnant monkeys caused abortion, or silver was detected in the brain of newborns after intraperitoneal injection of silver lactate in pregnant rats (ATSDR (1990), ACGIH (7th, 2001)). However, there is no information available for classification in this hazard class.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	It is written that there were incident cases of multiple people in high-level exposure to this substance, in which pathological symptom was not observed (HSDB (Access on June 2015)), but there is no detailed information. The classification is not possible due to lack of data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
9	Specific target organ toxicity - Repeated exposure	Category 1 (skin, thyroid, respiratory organs, systemic)	Danger	H372	P260 P264 P270 P314 P501	As the only information on this substance, it is reported that workers in the operation of artificial rainfall using this substance showed the coloring of hands but no health effects (HSDB (Access on June 2015)). However, the information on absorption of this substance in an inhalation route is written in ATSDR (2004) and CICAD 72 (2009), and the original literature (Willard, D.H. and Bar, W.J.: Acta Radiologica, 55, 486-496 (1961)) was obtained and investigated in details. As a result, in a disposition test in mice in inhalation exposure to 131I-silver iodide particles (Ag131I), it is shown that a total deposition rate of this insoluble substance was as low as about 12% which was about 1/5 in comparison with 131I2 (iodine) vapour, similarly exposed, but this substance was distributed in the whole body (multiple organs) after rapid absorption, and a distribution rate and time course of change per organ such as thyroid did not make much difference from one another in comparison based on total body burden (Willard, D.H. and Bar, W.J. (1961)). Therefore, it is conceivable that this substance is also absorbed in an inhalation route, and its toxicity reflects that of iodine, iodide, and silver compounds. As for silver compounds, it is written that long-term exposure causes argyria (PATTY (6th, 2012), ACGIH (7th, 2008), HSDB (Access on June 2015)). However, it is conceivable that it does not suggest serious health effects in humans. As for humans, for iodine and iodide, iodine causes hypothyroidism or hyperthyroidism (ACGIH (2008)), and for potassium iodide, other than iodine eruption and thyroid lesions, laryngitis, bronchitis, glottal edema, asthmatic attack, salivary gland edema, parotitis, gastritis, along with iodine cachexia such as generalized weakness, palpitation, depression, sleeplessness, and irritability are listed as iodine poisoning (Ethical Pharmaceuticals 2016). As above, other than skin, thyroid, and respiratory organs, various systemic signs for which it is difficult to identify a target organ were observed. Therefore, the substance was classified in Category 1 (skin, thyroid, respiratory organs, systemic toxicity).	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
10	Aspiration hazard	Classification not possible	- -	-	-	Due to lack of data, the classification is not possible.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	No data.	FY2015	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.1))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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