NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7783-99-5
Chemical Name	silver nitrite
Substance ID	m-nite-7783-99-5_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Classification not possible	- -	-	-	The substance is a nitrite containing a chemical group associated with explosive properties (N-O), but the classification is not possible due to no data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Flammable solids	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	It was classified as an oxidizing solid.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Pyrophoric solids	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Self-heating substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	Because a water solubility value was obtained, it is stable in water.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
14	Oxidizing solids	Category 2	Danger	H272	P370+P378 P210 P220 P280 P501	It is an inorganic compound containing oxygen, which is chemically bonded to elements other than carbon or hydrogen (N, Ag). It was classified as oxidizing in MSDS (Sigma-Aldrich) (Access on Sept. 2011), and it states that it is classified in Division 5.1, PG II in UNRTDG (UN2627 (NITRITES, INORGANIC, N.O.S.)). Therefore, it was classified in Category 2.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	It is an inorganic compound.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available. Besides, as for health hazards, please refer to those for sodium nitrite (CAS RN 7632-00-0) and silver nitrate (I) (CAS RN 7761-88-8), the related compounds.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available. Besides, it is described that silver nitrate, the related compound, is highly corrosive and may cause burns in the skin (NIOSH Publications (1978), corresponding to List 2).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available. Besides, it is described that silver nitrate, the related compound, is highly corrosive and may cause burns and irreversible damage in the eye (NIOSH Publications (1978)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
4	Skin sensitization	Classification not possible	- -	-	-	Silver is generally not considered a metal having dermal sensitization potential, but there have been rare instances and case reports in the scientific literature of individuals who have demonstrated an allergic reaction to silver or silver-containing materials (PATTY (5th, 2001)). However, it was classified as "Classification not possible" because no information specific to this substance was obtained.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available. Besides, some silver compound was reported to be negative in an Ames test and a chromosomal aberration test with CHO cells (both, in vitro mutagenicity tests) (IRIS (2003)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
6	Carcinogenicity	Classification not possible	- -	-	-	No data available. Besides, it is described in IARC that there is limited evidence in humans for the carcinogenicity of nitrite in food, nitrite in food is associated with an increased incidence of stomach cancer, and there is limited evidence in experimental animals for the carcinogenicity of nitrite. Furthermore, IARC classified ingested nitrate or nitrite under conditions that result in endogenous nitrosation in 2A for carcinogenicity (IARC 94 (2010)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
7	Reproductive toxicity	Classification not possible	- -	-	-	It is reported that no effect on fertility was found in a test by oral administration of silver compounds to experimental animals by drinking water (ATSDR (1990)), and silver and silver compounds have not been associated with reproductive toxicity (PATTY (5th, 2001)), but there are no data specific to this substance. It was classified as "Classification not possible" due to lack of data.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
8	Specific target organ toxicity - Single exposure	Category 1 (blood)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	It was classified in Category 1 (blood) because it is described that nitrite interacts with hemoglobin in human blood to generate methemoglobin, and high concentrations of methemoglobin are associated with hypotension, rapid pulse, and rapid breathing as a result of the vasodilatory effects of nitrite (IARC 94 (2010)). Besides, it is reported that due to exposure to dust containing relatively high levels of silver compounds such as silver nitrate or silver oxide, breathing problems, lung and throat irritation were seen in workers in chemical manufacturing facilities, and one man developed respiratory effects such as audible crackles during breathing, rapid pulse, a low oxygen content of capillary blood, and thickening of the lung observed in chest radiograms 14 hours after he had been working with molten silver ingots, his symptoms progressed to acute respiratory failure, from which he eventually recovered fully (ATSDR (1990)).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
9	Specific target organ toxicity - Repeated exposure	Category 1 (skin)	Danger	H372	P260 P264 P270 P314 P501	There is no information specific to this substance, but in humans, there are many case reports and epidemiological surveys in which long-term exposure to silver compounds caused deposition of silver in the skin, mucous membrane, or eye, and argyria. The change is not a toxic effect but an undesirable condition that is usually permanent (EPA RED (1992)). Therefore, it was classified in Category 1 (skin).	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in the Annexes to the Montreal Protocol.	FY2011	GHS Classification Guidance by the Japanese Government （July, 2010）

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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