NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7784-42-1
Chemical Name	Arsine
Substance ID	m-nite-7784-42-1_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	MHLW Website (in Japanese Only)
Sample SDS by MHLW (External link)	MHLW Website (in Japanese Only)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Flammable gases	Category 1	Danger	H220	P210 P377 P381 P403	Based on the description in ICSC (2004): the lower explosion limit is 4.5vol%. Classified into Division 2.1 (UN#2188) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Oxidizing gases	Not classified	- -	-	-	Classified into Division 2.1 and Division 2.3 (UN#2188) (UN Recommendations on the Transport of Dangerous Goods)	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Gases under pressure	Liquefied gas	Warning	H280	P410+P403	The boiling point is -62degC (ICSC (2004)) and the critical temperature is 100degC (HSDB (2006)), i.e., liquefied gas. Classified into Division 2.1 and Division 2.3 (UN#2188) (UN Recommendations on the Transport of Dangerous Goods).	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Flammable solids	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Self-reactive substances and mixtures	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Pyrophoric solids	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Self-heating substances and mixtures	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
14	Oxidizing solids	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Classified as "gas" according to GHS definition	FY2006	GHS Classification Manual （10 Feb, 2006）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to gas substances are not available	FY2006	GHS Classification Manual （10 Feb, 2006）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Gases)	Category 1	Danger	H330	P304+P340 P403+P233 P260 P271 P284 P310 P320 P405 P501	Based on the rat LC50 (inhalation of gas) value of 16.2ppm (4 hours).	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Vapours)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its vapour is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
1	Acute toxicity (Inhalation: Dusts and mists)	Not classified (Not applicable)	- -	-	-	Due to the fact that the substance is "gas" according to the GHS definition and inhalation of its dust/mist is not expected.	FY2006	GHS Classification Manual （10 Feb, 2006）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Respiratory sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
4	Skin sensitization	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
5	Germ cell mutagenicity	Classification not possible	- -	-	-	No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3."	FY2006	GHS Classification Manual （10 Feb, 2006）
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Due to the fact that the substance is classified as Category 1 (as ARSENIC AND ARSENIC COMPOUNDS) by IARC (1987) and Category K (as Arsenic Compounds, Inorganic) by NTP (2005).	FY2006	GHS Classification Manual （10 Feb, 2006）
7	Reproductive toxicity	Classification not possible	- -	-	-	No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenious Acid), CAS: 1327-53-3."	FY2006	GHS Classification Manual （10 Feb, 2006）
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system, blood system, cardiovascular system, respiratory organs, liver, kidney)	Danger	H370	P308+P311 P260 P264 P270 P321 P405 P501	Based on the human evidence: "clinical symptoms include transient hemolytic anemia, nausea, headache, anemia, decreased hemoglobin levels, erythema of the skin, jaundice, hemoglobinuria and shock" (IARC 84 (2004)), "pulmonary edema and acute circulatory disorder," "hepatitis on the 20th day after the acute hemolysis" (CICAD 47 (2002)), "hemolysis and nephropathy" (ACGIH (7th, 2001)), and the evidence from animal studies including "a 10.5% reduction in hematocrit levels observed in the 26ppm dose group" (CICAD 47 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
9	Specific target organ toxicity - Repeated exposure	Category 1 (blood system)	Danger	H372	P260 P264 P270 P314 P501	Based on the human evidence including "a decrease in hemoglobin level to 32g/L and basophilic stippling (in red blood cells)" (IARC 84 (2004)), and the evidence from animal studies including "anemia (decreased hemoglobin/hematocrit/RBC)" (CICAD 47 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.	FY2006	GHS Classification Manual （10 Feb, 2006）
10	Aspiration hazard	Not classified (Not applicable)	- -	-	-	Not applicable	FY2006	GHS Classification Manual （10 Feb, 2006）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
11	Hazardous to the aquatic environment Long term (Chronic)	Classification not possible	- -	-	-	No data available	FY2006	GHS Classification Manual （10 Feb, 2006）
12	Hazardous to the ozone layer	-	- -	-	-	-	-	-

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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