NITE - Chemical Management Field

Latest GHS Classification Results by the Japanese Government (edited by NITE)

GENERAL INFORMATION

Item	Information
CAS RN	7786-81-4
Chemical Name	Nickel sulphate
Substance ID	m-nite-7786-81-4_v1
Download of Excel format	Excel file

REFERENCE INFORMATION

Item	Information
Guidance used for the classification (External link)	To Guidance List
UN GHS document (External link)	To UN GHS document
FAQ（GHS classification results by the Japanese Government）	To FAQ
List of Information Sources (Excel file)	List of Information Sources
List of Definitions/Abbreviations	Definitions/Abbreviations
Sample Label by MHLW (External link)	To Workplace Safety Site (MHLW)
Sample SDS by MHLW (External link)	To Workplace Safety Site (MHLW)
OECD/eChemPortal (External link)	To OECD/eChemPortal (External link)

PHYSICAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Explosives	Not classified (Not applicable)	- -	-	-	There are no chemical groups associated with explosive properties present in the molecules.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Flammable gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Aerosols	Not classified (Not applicable)	- -	-	-	Not aerosol products.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Oxidizing gases	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Gases under pressure	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Flammable liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Flammable solids	Not classified	- -	-	-	Not combustible (ICSC (2004))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Self-reactive substances and mixtures	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Pyrophoric liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Pyrophoric solids	Not classified	- -	-	-	The substance is "Not combustible" (ICSC (2004)) and it does not spontaneously ignite on contact with room temperature air.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
11	Self-heating substances and mixtures	Not classified	- -	-	-	Not combustible (ICSC (2004))	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	- -	-	-	The substance is considered to be stable against water since data are available that water solubility is 40.4 g/100 g water (25 degC) (Lide (88th, 2003)) through it is a metal compound.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
13	Oxidizing liquids	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
14	Oxidizing solids	Classification not possible	- -	-	-	Classification is not possible since no data are available though the substance is inorganic compound containing oxygen which is chemically bonded to nickel or sulfur.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
15	Organic peroxides	Not classified (Not applicable)	- -	-	-	Inorganic compound	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
16	Corrosive to metals	Classification not possible	- -	-	-	Test methods applicable to solid substances are not available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
17	Desensitized explosives	-	- -	-	-	-	-	-

HEALTH HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
1	Acute toxicity (Oral)	Category 4	Warning	H302	P301+P312 P264 P270 P330 P501	Based on LD50 values of 46 mg/kg (male) and 39 mg/kg (female) (correspond to Category 2) (ATSDR (2005)); 500 mg/kg (correspond to Category 4) (ECETOC TR33 (1989)); 275 mg/kg (correspond to Category 3) (ECETOC TR33 (1989)) and 325 mg/kg (correspond to Category 4) (ECETOC TR33 (1989)) for rats, the substance was classified into Category 4since most of the values are in this category.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Dermal)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Gases)	Not classified (Not applicable)	- -	-	-	Solid (GHS definition)	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Vapours)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
1	Acute toxicity (Inhalation: Dusts and mists)	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
2	Skin corrosion/irritation	Classification not possible	- -	-	-	Although the result of a rabbit Draize test was reported (RTECS (2008)), the details of the result are not clear. Classification was not possible due to lack of data. As relevant information, in EU classification, the substance is classified into Xi; R38.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
3	Serious eye damage/eye irritation	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Respiratory sensitization	Category 1	Danger	H334	P304+P340 P342+P311 P261 P284 P501	Since nickel and its compounds are classified into R42/43 in EU classification (EU-Annex I (access on Jan. 2009)), Category 2 for respiratory tract sensitizer in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and respiratory tract sensitizer in DFG (MAK/BAT No.43 (2007)), the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
4	Skin sensitization	Category 1	Warning	H317	P302+P352 P333+P313 P362+P364 P261 P272 P280 P321 P501	The testing of 4140 patients with suspected contact allergic eczema revealed a nickel sensitization in 23.8% of women and 5.2% of men tested (DFGOT vol. 22 (2006)). In addition, nickel and its compounds are classified into R42/43 in EU classification, Category 1 for skin sensitizer in Japan Society For Occupational Health (JSOH), (Recommendations for allowable concentrations (2008)) and skin sensitizer in DFG (MAK/BAT No. 43 (2007)). Based on these data, the substance was classified into Category 1.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
5	Germ cell mutagenicity	Not classified	- -	-	-	Based on negative results in rat spermatogonium chromosomal aberration test (in vivo germ cell mutagenicity test) (EHC 108 (1991)), rat bone marrow chromosomal aberration test and mouse bone marrow micronucleus test (in vivo somatic cell mutagenicity tests) (EHC 108 (1991)), the substance was classified as "Not classified". As relevant information, from in vitro mutagenicity tests, there are reports of negative Ames test (EHC 108 (1991)), positive V79 cell gene mutation test (IARC 49 (1990)) and weakly positive mouse lymphoma test (EHC 108 (1991)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
6	Carcinogenicity	Category 1A	Danger	H350	P308+P313 P201 P202 P280 P405 P501	Based on the classifications of "Group 1" in IARC (IARC 49 (1999)), "Category 1" in EU classification (EU-Annex I (2009)), "1" in Japan Society For Occupational Health (JSOH) (Recommendations for allowable concentrations (2008)) and "K" in NTP (NTP RoC (11th, 2005)), the substance was classified into Category 1A. Soluble inorganic nickel is classified into "A4" in ACGIH (ACGIH-TLV (2008)).	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
7	Reproductive toxicity	Category 2	Warning	H361	P308+P313 P201 P202 P280 P405 P501	In a two-generation reproductive test in rats, there was no effect on the sexual function, fertility or histopathological findings in the reproductive organs. However, a significant increase in post-implantation losses, an increased number of dead pups at lactation day 0 and a decreased mean litter size were observed (ATSDR (2005)). In a multigeneration test involving exposure of rats in diet for 11 weeks prior to mating, during mating, gestation and lactation, a dose-related slight increase in the number of stillborn pups was observed (Hazard Assessment Report (CERI, NITE)). Although it is unknown whether parental general toxicity could be manifested at doses producing reproductive effects, the detrimental effects on reproduction were reported. The substance was classified into Category 2.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
8	Specific target organ toxicity - Single exposure	Classification not possible	- -	-	-	Although there is a report of pulmonary hemorrhage at 36.5 mg Ni/m3 (0.037 mg/L/2h; 4-hour equivalence: 0.018 mg/L/4h), which falls within the guidance value range for Category 1, following inhalation exposure in rats (ATSDR (2005)). Since the severity of the symptom is not clear, classification was not possible due to lack of other data. For health hazards, refer also to nickel chloride.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
9	Specific target organ toxicity - Repeated exposure	Category 1 (respiratory organs, male reproductive organs)	Danger	H372	P260 P264 P270 P314 P501	In a 13-week inhalation test in rats, chronic active pulmonary inflammation and increased segmented neutrophil numbers occurred at dose levels of >0.00006 mg Ni/L (female) and 0.00022 - 0.0004 mg Ni/L (male). Lymphocytosis, lymph node hyperplasia and atrophy of the olfactory epithelium were also observed at a dose level of 0.0004 mg Ni/L (male and female) (NTP TR454 (1996)). In a 2-year inhalation test in rats, lung lesions such as inflammatory lung lesions and fibrosis were observed at dose levels of 0.00006 mg Ni/L and/or 0.0001 mg Ni/L (male and female) (at 7 months, 15 months, the end of test). Lymphoid hyperplasia and atrophy of the olfactory epithelium were observed at a dose level of 0.0005 mg Ni/L (male and female) (at the end of test) (NTP TR454 (1996)). Since these findings in the nasal cavity and lung were noted at dose levels within the guidance value range for Category 1, the substance was classified into Category 1 (respiratory system). In a 120-day oral test in male rats, effects on the testis were observed at 25 mg Ni/kg which falls within the guidance value range for Category 2. In a 35-day oral test in mice, atrophy of seminal vesicle, epididymis and central sperm duct was observed at 1.1 mg Ni/kg which falls within the guidance value range for Category 1. Based on the data, the substance was classified into Category 1 (male accessory sex appendages). For health hazards, refer also to nickel chloride.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）
10	Aspiration hazard	Classification not possible	- -	-	-	No data available.	FY2009	GHS Classification Guidance by the Japanese Government （March, 2009）

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Pictogram Signal word	Hazard statement (code)	Precautionary statement (code)	Rationale for the classification	Classification year (FY)	GHS Classification Guidance for the Japanese Government
11	Hazardous to the aquatic environment Short term (Acute)	Category 2	- -	H401	P273 P501	From 48-hour EC50 = 5.27 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment Report, NITE, 2008), it was classified in Category 2.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
11	Hazardous to the aquatic environment Long term (Chronic)	Category 2	-	H411	P273 P391 P501	If chronic toxicity data are used, then it is classified in Category 2 due to unknown environmental dynamics of a metallic compound in water, and 14-day NOEC = 0.105 mg/L for fish (Danio rerio) (Initial Risk Assessment Report, NITE, 2008). If acute toxicity data are used for a trophic level for which chronic toxicity data are not obtained, then it is classified in Category 2 due to unknown environmental dynamics of a metallic compound in water, and 48-hour EC50 = 5.27 mg/L for crustacea (Daphnia magna) (Initial Risk Assessment Report, NITE, 2008). It was classified in Category 2 from the above results.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))
12	Hazardous to the ozone layer	Classification not possible	- -	-	-	This substance is not listed in Annexes to the Montreal Protocol.	FY2014	GHS Classification Guidance for the Japanese Government (FY2013 revised edition (Ver. 1.0))

NOTE:

GHS Classification Result by the Japanese Government is intended to provide a reference for preparing a GHS label or SDS for users. To include the same classification result in a label or SDS for Japan is NOT mandatory.
Users can cite or copy this classification result when preparing a GHS label or SDS. Please be aware, however, that the responsibility for a label or SDS prepared by citing or copying this classification result lies with users.
This GHS classification was conducted based on the information sources and the guidance for classification and judgement which are described in the GHS Classification Guidance for the Japanese Government etc. Using other literature, test results etc. as evidence and including different content from this classification result in a label or SDS are allowed.
Hazard statement and precautionary statement will show by hovering the mouse cursor over a code in the column of "Hazard statement" and "Precautionary statement," respectively. In the excel file, both the codes and statements are provided.
A blank or "-" in the column of "Classification" denotes that a classification for the hazard class was not conducted in the year.
An asterisk “*” in the column of “Classification” denotes that “Not classified (or No applicable)” and/or “Classification not possible” is applicable. Details are described in the column of “Rationale for the classification”. If no English translation is available for “Rationale for the classification,” please refer to the Japanese version of the results.

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